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A Note on the Effect of Trifluoroacetate on the Growth of Rat Liver

  • D. A. Blake
  • J. Q. Barry
  • H. F. Cascorbi
Chapter

Summary

The influence of trifluoroacetic acid (TFAA) and sodium trifluoroacetate (TFA) on the liver weight to body weight ratio was measured in rats by two methods. When TFA or TFAA were added to the drinking water at a concentrate of 1 Normal, rats became dehydrated and a slight increase in the ratio was noted after ten days. However, when these substances were administered to rats (1 ml per day) by gastric intubation no change in the ratio was noted after eight days.

Key-Words

Trifluoroacetic Acid Trifluoroacetate Rat Liver Weight 

Schlüsselwörter

Trifluoressigsäure Trifluoroacetat Ratte Lebergewicht 

References

  1. 1.
    Blake, D.A., Cascorbi, H.F., Rozman, R.S., Meyer, F.J.: Animal toxicity of 2, 2, 2-Trifluoroethanol. Toxicol. appl. Pharmacol. 15, 83–91 (1969).PubMedCrossRefGoogle Scholar
  2. 2.
    Remmer, H., Merker, H.J.: Enzyminduktion und Vermehrung von endoplasmatischem Reticulum in der Leberzelle während der Behandlung mit Phenobarbital (Luminal). Klin. Wochensch. 41, 276 (1963).CrossRefGoogle Scholar
  3. 3.
    Schimassek, H., Helms, J., Kunz, W., Stier, A.: Lebervergrößerung unter Trifluoressigsäure, Spaltprodukt des Halothan. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 67 (1966).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • D. A. Blake
    • 1
  • J. Q. Barry
    • 1
  • H. F. Cascorbi
    • 1
  1. 1.Department of PharmacologyUniversity of Maryland, School of PharmacyBaltimoreUSA

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