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Der Einfluß der Durchblutung auf die Wasser- und Salzresorption im Jejunum der Ratte

  • Dietrich Winne
Chapter

Schlüsselwörter

Darmdurchblutung Wasserresorption Salzresorption Jejunum Ratte 

Summary

  1. 1

    The lumen of jejunal loops in rats anaesthetised with urethane were perfused with hypo-, iso- and hypertonic ringer, mannitol or glucose ringer solution. The blood flow (venous outflow), water, solute and glucose net flux were measured in the loop.

     
  2. 2

    Lowering the blood flow from 1 ml/min/g wet tissue to 0.2–0.3 ml/min/g caused the solute and glucose net flux to decrease; the water net flux (positive or negative) was also decreased if non-isotonic solutions were used, but remained unchanged when isotonic solutions were perfused.

     
  3. 3

    When the blood flow was raised from 0.2–0.3 ml/min/g to 1 ml/min/g the net flux of glucose, solute and water usually remained low. Using hypotonic solutions the water net flux changed to negative values, that is, fluid was passing into the lumen.

     
  4. 4

    The influence of intestinal blood flow on water, solute and glucose absorption can be referred to 3 factors: a) drainage by blood, b) inhibition of active transport mechanisms by anoxia during low blood flow, and c) damage to the villi as a result of insufficient blood flow.

     

Key-Words

Intestinal Blood Flow Water Absorption Solute Absorption Jejunum Rat 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • Dietrich Winne
    • 1
  1. 1.Pharmakologisches InstitutUniversität TübingenTübingenDeutschland

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