Inhibition of Amine Oxidases by Nitrofuran Derivatives: Possible Structure-Activity Relations and Criteria of Irreversibility

  • K. Quiring
  • D. Palm


Four bacteriostatically active nitrofurfurylidene compounds and their respective hydrazine moieties were administered to male Wistar rats. MAO activity was measured in vivo by different methods in liver, brain, and small intestine. Inhibition of DAO activity was determined in small intestine of rats and, in in-vitro experiments, in a partially purified pig kidney enzyme preparation.

It is stated that, inter alia, accordance between enzyme reactivation rate and enzyme protein turnover rate is a criterion for an irreversible MAO inhibitor.


Monoamine Oxidase MAO Inhibitors Nitrofurans Hydrazines Enzyme Inhibition (Irreversible) 


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© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • K. Quiring
    • 1
  • D. Palm
    • 1
  1. 1.Pharmakologisches Institut der Universität6 Frankfurt a. M. 70Deutschland

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