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Bedeutung der Nebennierenkatecholamine für die reflektorische kardiovasculäre Gegenregulation bei renal hypertonischen Ratten

  • H. Brunner
  • P. R. Hedwall
Chapter

Schlüsselwörter

Kreislaufreflexe Nebennierenmark Catecholamine Sympathicolytica Hypertonische Ratte 

Summary

The antihypertensive effects of oxprenolol, an adrenoceptive beta-receptor blocking agent, hydralazine or a combination of both compounds were compared in intact and adrenal demedullated rats. Blood pressure in the conscious animal was measured according to the method of Gerold, et al., and in the anaesthetized rat according to the method of Byrom and Wilson.

Although oxprenolol had no influence on blood pressure in the intact rat, an antihypertensive effect was seen in conscious or anaesthetized, demedullated animals. The antihypertensive effect of hydralazine was more pronounced in conscious, intact rats than in conscious, demedullated rats, while its effect was similar in anaesthetized, intact or demedullated rats.

An antagonism of the effect of hydralazine by oxprenolol was seen in intact, but not in demedullated animals. In the conscious, demedullated animal oxprenolol enhanced the antihypertensive effect of hydralazine.

It can be concluded that adrenal catecholamines play a major role in reflex adjustment to a fall in blood pressure and that this effect can be enhanced by adrenergic beta-receptor blockade.

Key- Words

Cardiovascular Reflexes Adrenal Medulla Catecholamines Sympatholytics Hypertensive Rat 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • H. Brunner
    • 1
  • P. R. Hedwall
    • 1
  1. 1.Biologische LaboratorienCIBA Aktiengesellschaft Basel, Pharmazeutische AbteilungSchweiz

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