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Über die gestörte Glucuronidsynthese in der Leber diabetischer Ratten

  • B. Müller-Oerlinghausen
Chapter

Schlüsselwörter

Diabetes Glucuronide Insulin Leber Uridindiphosphat-Glucuronsäure 

Abkürzungen

AIS

Anti-Insulin-Serum

ATP

Adenosin-triphosphat

NAD+

Nicotinamid-Adenin-Dinucleotid

oAP

o-Aminophenol

UDPG

Uridin-diphosphat-glucose

UDPGA

Uridindiphosphat-Glucuronsäure.

Summary

The synthesis in vitro of o-aminophenol-glucuronide by liver tissue has been investigated in diabetic rats. Insulin deficiency was induced by withdrawal of insulin in alloxan treated, insulin substituted rats or by injection of anti-insulin-serum. The hepatic formation of o-aminophenol-glucuronide was strongly reduced under these conditions. This result could not be explained by differences in the activity of the UDP-glucuronyl-transferase. However, the concentration of UDP-glucuronic acid in liver tissue of the diabetic rats was also decreased to 50% of control values whereas the amount of UDPG was augmented. These findings are consistent with the observation that the activity of UDPG-dehydrogenase, the enzyme catalyzing the formation of UDP-glucuronic acid from UDPG, is reduced in the liver of diabetic or fasting rats. The activity of the UDPGA-pyrophosphatase which is responsible for inactivation of the nucleotide, has been found to be unchanged in the diabetic animals.

Key-Words

Diabetes Glucuronates Insulin Liver Uridine-Diphosphateglucuronic acid 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • B. Müller-Oerlinghausen
    • 1
    • 2
  1. 1.Institut für Pharmakologie und Toxikologie der UniversitätGöttingenDeutschland
  2. 2.Dept. of Medical SciencesMinistry of Public Health Yod-se/BangkokThailand

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