Die Wirkung verschiedener blutdrucksenkender Pharmaka auf Wasseraufnahme und -abgabe bei Ratten

  • B. Peskar
  • S. Leodolter
  • G. Hertting


Trinken Antidiurese Blutdrucksenkende Pharmaka. 


Hydrazinophthalazines, Phentolamine, Phenoxybenzamine, Nylidrine and Isoxsuprine elicit a drinking response and simultaneous antidiuresis in rats. The effect of Hydralazine and Phentolamine on drinking is potentiated by the neuronal sympathetic blocking agents, Bretylium and Guanethidine. If Guanethidine or Bretylium was administered alone in the same dosage, only minor effects on drinking and diuresis were observed. Control animals given 8 ml water by tube excreted 80% of the fluid load within 2 hours, whilst animals pretreated with the combination of Bretylium and Hydralazine showed complete antidiuresis. The plasma volume was increased by 15% in the pretreated group. Since on examination of the intestines it was apparent that the water had been entirely absorbed, it must be assumed that the major part of the fluid had been transferred to the extravascular compartment. Propranolol blocked the effect of both Phentolamine and Hydralazine on drinking.


Drinking Antidiuresis Hypotensive Drugs 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Åblad, B.: A study of the mechanism of the hemodynamic effects of hydralazine in man. Acta pharmacol. (Kbh.) 20, Suppl. 1, 1–53 (1963).Google Scholar
  2. Bein, H.J., Brunner, H.: Mode of action of antihypertensive drugs. Antihypertensive therapy, F. Gross, ed., p. 15. Berlin-Heidelberg-New York: Springer 1966.CrossRefGoogle Scholar
  3. Brunner, H. — Gross, F., Tripod, J., Meier, R.: Experimentelle Untersuchungen über die Kreislaufwirkung der blutdrucksenkenden Hydrazinophthalazinderivate Apresolin und Nepresol. Schweiz, med. Wschr. 83, 336–340 (1953).Google Scholar
  4. Brunner, H., Hedwall, P.R., Meier, M.: Influence of an adrenergic β-receptor blocking agent on the effect of various hypotensive agents in the hypertensive rat. Experientia (Basel) 21, 231–234 (1965).CrossRefGoogle Scholar
  5. Hedwall, P.R., Meier, M. — Influence of adrenergic beta-receptor blockade on the acute cardiovascular effects of hydralazine. Brit. J. Pharmacol. 30, 123–133 (1967).PubMedGoogle Scholar
  6. Fitzsimons, J.T.: The role of a renal thirst factor in drinking induced by extracellular stimuli. J. Physiol. (Lond.) 201, 349–368 (1969a).Google Scholar
  7. — Simons, B.J.: The effect on drinking in the rat of intravenous infusion of angiotensin, given alone or in combination with other stimuli of thirst. J. Physiol. (Lond.) 203, 45–58 (1969b).Google Scholar
  8. Füllgraff, G., Heidenreich, O., Heintze, K., Osswald, H.: Die Wirkung von a-und β-Sympathomimetica und Sympatholytica auf die renale Excretion und Resorption von Flüssigkeit und Elektrolyten in Ausscheidungs-und Mikropunktionsversuchen an Ratten. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 262, 295–308 (1969).CrossRefGoogle Scholar
  9. Gauer, O.A., Henry, J.E.: Circulatory basis of fluid volume control, Physiol. Rev. 43, 423–481 (1963).Google Scholar
  10. Gross, F., Tripod, J., Meier, R.: Regitin (Präparat C 7337), ein neues Imidazolinderivat mit spezifischer sympathicolytischer Wirkung. Schweiz, med. Wschr. 81, 352–357 (1951).Google Scholar
  11. Lehr, D., Mallow J., Krukowski, M.: Copious drinking and simultaneous inhibition of urine flow elicited by beta-adrenergic stimulation and contrary effect of alpha-adrenergic stimulation. J. Pharmacol. exp. Ther. 158, 150–163 (1967).PubMedGoogle Scholar
  12. Mellander, S., Johansson, B.: Control of resistance, exchange, and capacitance functions in the peripheral circulation. Pharmacol. Rev. 20, 117–196 (1968).PubMedGoogle Scholar
  13. Miller, N.: Chemical coding of behavior in brain. Science 148, 328–338 (1965).PubMedCrossRefGoogle Scholar
  14. Taylor, S.H., Sutherland, G.R., MacKenzie, G.J., Staunton, H.P., Donald, K.W.: The circulatory effects of intravenous phentolamine in man. Circulation 31, 741–754 (1965).PubMedCrossRefGoogle Scholar
  15. Weil-Malherbe, H., Axelrod, J., Tomchick, R.: Blood-brain barrier for adrenaline. Science 129, 1226–1227 (1959).PubMedCrossRefGoogle Scholar
  16. Axelrod, J., Tomchick, R. — Whitby L.G., Axelrod, J.: The uptake of circulating (3H) norepinephrine by the pituitary gland and various areas of the brain. J. Neurochem. 8, 55–64 (1961).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • B. Peskar
    • 1
  • S. Leodolter
    • 1
  • G. Hertting
    • 1
  1. 1.Pharmakologisches Institut der UniversitätWienÖsterreich

Personalised recommendations