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Ein Substanz P-Standardpräparat

  • J. Baldauf
  • K. Gebhardt
Chapter

Schlüsselwörter

Substanz P-Standardpräparat Hirnpeptid 

Summary

  1. 1

    Fraction Fa of crude substance P (SP), made from brain and gut, causes, in contrast to the SP peptide Fb, a relaxation of the isolated rat duodenum. Fraction Fa is therefore not a suitable SP standard preparation.

     
  2. 2

    By means of sephadex gel filtration, a relaxing component can be separated from the contracting Fa peptide.

     
  3. 3

    The relaxing Fa component is acidic, but is neither a peptide nor prosta-glandin F

     
  4. 4

    Purified Fa material from brain is recommended as SP standard preparation.

     

Key-Words

Substance P-Standard Preparation Brain Peptide 

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Literatur

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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • J. Baldauf
    • 1
  • K. Gebhardt
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieUniversität des SaarlandesHomburg/SaarDeutschland

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