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Enhancement of Coronary Reactive Hyperemia in Unanaesthetized Pigs by an Adenosine-Potentiator (Lidoflazine)

  • A. H. M. Jageneau
  • W. K. A. Schaper
  • W. van Gerven
Chapter

Summary

The potentiation of coronary reactive hyperemia by oral doses of Lidoflazine after different periods of coronary artery occlusion in non-anaesthetized miniature pigs is described.

Doses varying from 2.5 to 80 mg/kg of Lidoflazine were investigated and occlusion periods from 10 to 80 sec were used.

Coronary blood flow was measured by an electromagnetic flowmeter and the occlusions were performed with a pneumatic occlusive device.

The enhancement of the reactive hyperemic response is believed to result from potentiation of a transmitter substance, probably adenosine, by Lidoflazine.

Key-Words

Coronary Circulation Reactive Hyperemia Pig 

Schlüsselwörter

Coronarkreislauf Reaktive Hyperämie Schwein 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • A. H. M. Jageneau
    • 1
  • W. K. A. Schaper
    • 1
  • W. van Gerven
    • 1
  1. 1.Cardiovascular Research LaboratoriumJanssen PharmaceuticaBeerseBelgium

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