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Inhibition of the Effect of Reserpine on Motor Control by Drugs which Influence Reserpine Rigidity

  • I. Jurna
  • G. Lanzer
Chapter

Summary

The effect of monoaminergic (DOPA, metamphetamine, propylhexedrine) and cholinolytic agents (atropine, biperiden, caramiphen, trihexyphenidyl) on α and γ reflex discharge from the spinal cord was studied in the rat. For comparison, the anticonvulsant phenytoin was included in the investigation. All drugs antagonized the action of a high dose of reserpine on motor control by reducing the increased α and increasing the diminished γ reflex activity. The latency of α reflex discharge shortened by reserpine was increased by the drugs. The results provide further support of the view that disturbance of motor control caused by reserpine in the rat derives from an imbalance between monoaminergic and cholinergic systems in the brain.

Key-Words

Spinal motor activity Reserpine Monoaminergic agents Cholinolytic agents Antiparkinson drugs Phenytoin 

Schlüsselwörter

spinalmotorische Aktivität Reserpin Monoaminergica Cholinolytica Antiparkinsonstoffe Phenytoin 

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References

  1. Arvidsson, J., B.-E. Roos, and G. Steg: Reciprocal effects on α-and γ-moto-neurones of drugs influencing monoaminergic and cholinergic transmission. Acta physiol. scand. 67, 398–404 (1966).PubMedCrossRefGoogle Scholar
  2. Esplin, D. W.: Effects of diphenylhydantoin on synaptic transmission in cat spinal cord and stellate ganglion. J. Pharmacol. exp. Ther. 120, 301–323 (1957).PubMedGoogle Scholar
  3. Jurna, I.: Reserpine rigidity in the rat—a model for the analysis of anti-parkinson drugs. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 259, 181 (1968a).CrossRefGoogle Scholar
  4. — Depression by antiparkinson drugs of reserpine rigidity. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 260, 80–88 (1968b).CrossRefGoogle Scholar
  5. —, and B. Regélhy: The antagonism between reserpine and some antiparkinson drugs in electroseizure. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 259, 442–459 (1968).CrossRefGoogle Scholar
  6. Raines, A., and F. G. Standaert: An effect of diphenylhydantoin on posttetanic hyperpolarization of intramedullary nerve terminals. J. Pharmacol. exp. Ther. 156, 591–597 (1967).PubMedGoogle Scholar
  7. Roos, B.-E., and G. Steg: The effect of l-DOPA and 5-HTP on rigidity and tremor induced by reserpine, chlorpromazine and phenoxybenzamine. Life Sci. 3, 351–360 (1964).PubMedCrossRefGoogle Scholar
  8. Steg, G.: Efferent muscle innervation and rigidity. Acta physiol. scand. 61, suppl. 225 (1964).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • I. Jurna
    • 1
  • G. Lanzer
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieUniversität des SaarlandesHomburg (Saar)Deutschland

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