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Metabolism of N-Acyl-Chloroanilines Stoffwechsel von N-Acyl-Chloranilinen

  • M. Kiese
  • W. Lenk
Chapter

Abstract

Rabbits excrete certain para-substituted acetanilides as the corresponding glycolanilides and oxanilic acids [2]. The hydroxylation of acetic acid to glycolic acid in acetanilides is carried out by microsomal oxygenases. We isolated 4-chloro-glycolanilide from suspensions of rabbit liver and kidney microsomes incubated with 4-chloro-acetanilide. The importance of the 4-position being substituted is shown by 3-chloro-acetanilide being excreted to only 0.1% of the dose and 2-chloro-acetanilide in untraceable amounts as glycolanilide. None of the acetanilides, a large portion of which was excreted as a glycolanilide, were found in the urine as hydroxamic acid. On the other hand, N-(2-fluorenyl)-acetanilide, of which up to 30% is found in the urine as the N-hydroxy derivative [1], was excreted to only about 0.1% as N-(2-fluorenyl)-glycolamide.

References

  1. 1.
    Irving, C.C.: Cancer Res. 22, 867 (1962).Google Scholar
  2. 2.
    Kiese, M., and W. Lenk: Biochem. Pharmacol. (in press).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • M. Kiese
    • 1
  • W. Lenk
  1. 1.Pharmakologisches Institut der UniversitätMünchen 15Deutschland

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