Oxidative Drug Metabolism Following Low Carbon Disulphide Concentrations / Oxydativer Arzneimetabolismus unter geringen Schwefelkohlenstoffkonzcntrationen

  • K. J. Freundt
  • P. Kuttner


The side chain oxidation of hexobarbital is inhibited in rats during and after exposure to low CS2 concentrations (Freundt and Dreher [1]). We investigated the effects of CS2 exposure on other important metabolic pathways of drugs: C-hydroxylation, N-demethylation, O-glucuronida-tion, and N-acetylation.


  1. 1.
    Freundt, K.J., and W. Dreher: Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 263, 208 (1969).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • K. J. Freundt
    • 1
  • P. Kuttner
  1. 1.Institut für Toxikologie und Pharmakologie der UniversitätWürzburgDeutschland

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