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The Effect of Physostigmine and Tetrabenazine on Spinal Motor Control and its Inhibition by Drugs which Influence Reserpine Rigidity

  • I. Jurna
  • C. Theres
  • T. Bachmann
Chapter

Summary

The effect of monoaminergic (DOPA, metamphetamine, propylhexedrine) and cholinolytic agents (atropine, biperiden, caramiphen, trihexyphenidyl) on spinal motor control disturbed by physostigmine and tetrabenazine was studied in the rat. In addition the anticonvulsant agent phenytoin was included in the investigation. Physostigmine and tetrabenazine produced rigidity, increased a reflex discharge, shortened the latency of α reflex discharge and decreased γ reflex discharge. Rigidity as well as the action of physostigmine and tetrabenazine on α motor activity were inhibited by the drugs. The results are in accordance with the hypothesis that parkinsonlike rigidity in the rat results from hyperactivity of the α motor system, which is due to an imbalance between monoaminergic and cholinergic mechanisms in the brain.

Key-Words

Spinal Motor Activity Physostigmine Tetrabenazine Monoaminergic Agents Cholinolytic Agents Antiparkinson Drugs Phenytoin. 

Zusammenfassung

Die Wirkung von monoaminergen (DOPA, Metamphetamin, Propylhexedrin) und cholinolytischen (Atropin, Biperiden, Caramiphen, Trihexyphenidyl) Substanzen auf die durch Physostigmin und Tetrabenazin gestörte Kontrolle der spinalen Motorik wurde an Ratten geprüft. Zusätzlich wurde das Anticonvulsivum Phenytoin in die Untersuchung einbezogen. Unter dem Ein-fluß von Physostigmin und Tetrabenazin entwickelte sich ein Rigor, die reflektorische Entladung von α-Motoneuronen wurde gesteigert, die Latenz der reflektorischen α-Entladung verkürzt und die Aktivität der γ-Motoneurone vermindert. Die monoaminergen und cholinolytischen Substanzen dämpften den Rigor und die gesteigerte Reflexaktivität der α-Motoneurone. Die Befunde stehen in Einklang mit der Ansicht, daß der parkinsonähnliche Rigor der Ratte auf einer Hyperaktivität des α-motorischen Systems beruht, die ihrerseits Folge des gestörten Gleichgewichtes zwischen monoaminergen und cholinergen Systemen des Gehirns ist.

Schlüsselwörter

Spinalmotorische Aktivität Physostigmin Tetrabenazin Monoaminergica Cholinolytica Antiparkinsonstoffe Phenytoin. 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • I. Jurna
    • 1
    • 2
  • C. Theres
    • 1
  • T. Bachmann
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieUniversität des SaarlandesHomburg (Saar)Deutschland
  2. 2.Pharmakologisches Institutder Universität des SaarlandesHomburg/SaarDeutschland

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