The Action of Adrenal Steroids on the Pharmacological Reactivity of the Isolated Vein of the Rabbit Ear
The isolated perfused central vein of the rabbit ear has been used to investigate potentiation by adrenal steroids of the actions of bradykinin, histamine and noradrenaline.
Potentiation of all substances occurred when adrenal steroids in large doses were added to the perfusate but was neither large in magnitude nor constant in occurrence. Potentiation was seen with cortisol and dexamethasone and their potency was in the same relationship as their glucocorticoid activity. However aldosterone was roughly equi-potent with dexamethasone.
Thus the potentiation by steroids in this preparation is non-specific in that BK and histamine as well as noradrenaline responses are affected. The potency of steroids does not parallel either glucocorticoid or mineralocorticoid activity and so these results do not suggest an effect of steroids on either specific receptors or membrane electrolyte distribution.
Key-WordsCatecholamines Plasma Kinins Histamine Glucocorticoid Aldosterone.
SchlüsselwörterBrenzcatechinamin Plasmakinin Histamin Glucocorticoid Aldosteron.
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- —, and G. Cummings: Comparative potentiating action of various steroids on contraction of vascular smooth muscle. Fed. Proc. 17, 17 (1958).Google Scholar
- D’Agostino, S.A., and E.T. Segura: Effect of aldosterone and corticosterone upon vasomotor reactivity in adrenalectomised rats. Acta physiol. lat.-amer. 14, 352–357 (1964).Google Scholar
- Goodman, L.S., and A. Gilman: The pharmacological basis of therapeutics, 3rd edition, p. 1633. New York: Macmillan 1965.Google Scholar
- Guth, P.S., R. Bobbin, G. Cano, and J. Amaro: Venoconstriction induced by bradykinin in the intact and denervated rabbit ear. Fed. Proc. 25, 287 (1966).Google Scholar
- Horowitz, J.D., and M.L. Mashford: A perfused vein preparation sensitive to plasma kinins. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 263, 332 to 339 (1969).Google Scholar