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Zusammenfassung

Ionisierende magnetische und corpusculäre Strahlungen lösen in den betroffenen Geweben chemische Veränderungen aus, die ihre Lebensfähigkeit mehr oder weniger stark herabsetzen. Auch bei gleicher Ionisation begegnen wir verschiedenen Schädigungsgraden. Die Zellen müssen demnach eine unterschiedliche Strahlenempfindlichkeit haben.

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Literatur

  1. Ackermann, L.V., and J.-A. del Regato: Cancer. diagnosis, treatment and prognosis. St. Louis: C.V. Mosby Co. 1954.Google Scholar
  2. Albers-Schönberg, H.E.: Über eine bisher unbekannte Wirkung der Röntgenstrahlen auf den Organismus der Tiere. Münch. med. Wschr. 50, 1859 (1903).Google Scholar
  3. Alberti, W., u. G. Politzer: Experimentalbiologische Vorstudien zur Krebstheorie. Fortschr. Röntgenstr. 32, 56–64 (1924).Google Scholar
  4. Ancel et P. Vintenberger: In: Z.M. Bacq, L’influence de certains facteurs métaboliques sur la radiosensibilité. Rapport du Symposium sur la Radiosensibilité. Québec: Laval Méd. Inc. 1963.Google Scholar
  5. Andersen, S.R.: Differentiation and irradiation. Acta radiol. (Stockh.) 33, 57–68 (1950).Google Scholar
  6. D’Angio, G.J.: Laboratory and clinical observation with combined actinomycin and X-radiation. Rapport du Symposium sur la Radiosensibilité, Québec 1962, p. 137-139. Québec: Laval Méd. Inc. 1963.Google Scholar
  7. Baclesse, F., et R. Delaplace: Sensibilisation chimique en radiothérapie. Résultats cliniques. Antibiotica et Chemotherapia, Fortschritte. Basel: S. Karger. Separatum, vol. 8, 374–376 (1960).Google Scholar
  8. Baclesse, F., et G. Dulac: Les tumeurs malignes du rhinopharynx. Assoc. franç. pour Étude cancer 31, 160–177 (1943).Google Scholar
  9. Baclesse, F., J.-F. Duplan et R. Royer: Méthode d’évaluation de la radiosensibilisation des cellules cancéreuses. Bull. Ass. franç. Cancer 51, 395–406 (1964).PubMedGoogle Scholar
  10. Baclesse, F., G. Gricouroff, et A. Tailhefer: Essai de roentgenthérapie du cancer du sein suivie d’opération large; résultats histologiques. Bull. Ass. franç. Cancer 28, 729–743 (1939).Google Scholar
  11. Bacq, Z.M., et P. Alexander: Principes de radiobiologie. Paris: Masson & Cie. 1955.Google Scholar
  12. Bagshaw, M.A.: Approaches for combined radiation and chemotherapy. Quebec Symp. on Radiosensibility. Laval méd. 1963, 124-133.Google Scholar
  13. Bauer, R.: Das Krebsproblem. Berlin-Göttingen-Heidelberg: Springer 1949.Google Scholar
  14. Bergonié, J., et L. Tribondeau: Interprétation de quelques résultats de la radiothérapie et essai de fixation d’une technique rationelle. C.R. Soc. Biol. (Paris) 143, 983 (1906).Google Scholar
  15. Betz, H., et L. Fruhling: Etude de la régénération des organes hématopoiétiques chez les souris irradiées à fortes doses et protégées par injéction de KCN.C.R. Soc. Biol. (Paris) 144, 1013–1015 (1950).Google Scholar
  16. Black, M.M., S. Kerpe, and F.G. Speer: Lymphnode structure in patients with cancer of breast. Amer. J. Path. 29, 505–521 (1953).PubMedGoogle Scholar
  17. Bloom, J.G.: Influence of histological structure on radiosensitivity of tumours. Symposium; role of histology in treatment of breast cancer. Brit. J. Radiol. 29, 488–497 (1956).PubMedGoogle Scholar
  18. Bohn, G.: Influence des rayons du radium sur les animaux en voie de croissance. C.R. Acad. Sci. (Paris) 136, 1012 (1903).Google Scholar
  19. Borders, A.C.: Squamous-cell epithelioma of the lips; a study of 537 cases. J. Amer. med. Ass. 74, 656–664 (1920).Google Scholar
  20. Borders, A.C.: The grading of carcinoma. Minn. Med. 8, 726–730 (1925).Google Scholar
  21. Borders, A.C.: Carcinoma; grading and practical application. Arch. Path. 2, 376–381 (1926).Google Scholar
  22. Bordier, H.: Action biochimique des radiations et en particulier des radiations de Röntgen. Arch. Élect. méd. 21, 289 (1913).Google Scholar
  23. Brunner, K.W.: Grundsätze der chemotherapeutischen Behandlung der Krebskrankheiten. Schweiz. med. Wschr. 95, 789-799, 1279–1289 (1965).Google Scholar
  24. Buschke, F.: Vierzehn Jahre Supervolt-Röntgentherapie. Swedish Hospital. Seattle/USA. Schweiz. med. Wschr. 83, 641 (1953).Google Scholar
  25. Caspersson, T., and L. Santersson: Cell growth and cell function. New York: W.W. Norton & Co. Inc. 1950.Google Scholar
  26. Cherry, C.P.: Radiation effects on normal endocervix and on adenocarcinomas of cervix. J. Obstet. Gynaec. Brit. Emp. 58, 774–779 (1951).PubMedGoogle Scholar
  27. Cherry, C.P., and A. Glücksmann: The influence of systemic factors on the reaction to radium treatment of the normal and malignant epithelium of the uterine cervix. Cancer (Philad.) 7, 504 (1954).Google Scholar
  28. Churchill-Davidson, J., A.C. Sanger, and R.H. Thomlinson: High-pressure oxygen and radiotherapy. Lancet 1955I, 1091-1095.Google Scholar
  29. Cornil, L., and A. Stahl: Nucleic acids in the cancerous cell and radiosensitivity. Acta Un. int. Cancr. 7, 818 (1952).PubMedGoogle Scholar
  30. Coutard, H.: Chronological factors in radiation therapy. J. appl. Physics 12, 329–330 (1941).Google Scholar
  31. Cramer, W.: Experimental observations on therapeutic action of radium. Sci. Rep. Cancer Res. Fd (Lond.) 10, 95–123 (1932).Google Scholar
  32. Crowther, J.A.: Some considerations relative to the action of X-rays on tissue cells. Proc. roy. Soc. B 96, 207 (1924).Google Scholar
  33. Daly, J.F., and M. Friedman: Combined irradiation and chemotherapy in the treatment of squamous cell carcinoma of the head and neck. Trans. Amer. Acad. Ophthal. Otolaryng. 625-643 (1964).Google Scholar
  34. Desjardins, A.-V.: A classification of tumors from the stand’s point of radiosensitiveness. Amer. J. Roentgenol. 32, 493 (1934).Google Scholar
  35. Dessauer, F.: Zur Erklärung der biologischen Strahlenwirkungen. Strahlentherapie 16, 208 (1923).Google Scholar
  36. Djordjevic, B., and W. Szybalski: Genetics of human cell lines. III. Incorporation of 5-bromo-and 5-iododeoxyuridine into the deoxyribonucleic acid of human cells and its effect on radiation sensitivity. J. exp. Med. 112, 509–531 (1960).PubMedCentralPubMedGoogle Scholar
  37. Ellinger, F.: Medical radiation biology. Springfield: Ch. C. Thomas 1957.Google Scholar
  38. Elward, J.-F., and J.-F. Belair: Relative degrees of radiosensitivity of tissue. Radiology 33, 450–461 (1939).Google Scholar
  39. Englmann, K.: Zit. in: H. Holfelder, Die Röntgentief entherapie, S. 26–80. Leipzig: Georg Thieme 1938.Google Scholar
  40. Feine, U., and O. Hug: In: Rajewsky, Wissenschaftliche Grundlagen des Strahlenschutzes. Karlsruhe: G.Braun 1957.Google Scholar
  41. Forssberg, A.: Some experiments in irradiating drosophila eggs with roentgen rays and gamma rays in a magnetic field. Acta radiol. (Stockh.) 21, 213 (1940).Google Scholar
  42. Garces, B.: Contrôle cytologique de l’irradiation. Bull. Ass. franç. Cancer 44, 492-499 (1957).Google Scholar
  43. Ghys, R.: L’influénce des facteurs métaboliques sur la radiosensibilité. Symp. sur la Radiosensibilité, p. 69. Quebec. Québec: Laval Méd. Inc. 1963.Google Scholar
  44. Glocker, R.: Über das Grundgesetz der physikalischen Wirkungen von Röntgenstrahlen verschiedener Wellenlänge. Z. Phys. 42, 825 (1927).Google Scholar
  45. Glücksmann, A.: Preliminary observations on the quantitative examination of human biopsy material taken from irradiated carcinomata. Brit. J. Radiol. 14, 187–198 (1941).Google Scholar
  46. Glücksmann, A.: II. The response of human tissues to radiation with special reference to differentiation. Brit. J. Radiol. 25, 38–43 (1952).PubMedGoogle Scholar
  47. Glücksmann, A.: The influence of systemic factors on the differentiation and radiocurability of cervical cancers. Brit. J. Radiol. 29, 423 (1956).Google Scholar
  48. Glücksmann, A., et F.G. Spear: The qualitative and quantitative histological examination of biopsy material from patients treated by radiation for carcinoma of the cervix uteri. Brit. J. Radiol. 18, 313–322 (1945).Google Scholar
  49. Graham, R.M., and J.B. Graham: A cellular index of sensibility on ionising irradiation. Cancer (Philad.) 2, 215 (1953).Google Scholar
  50. Gray, L.H.: Radiobiologic basis of oxygen as a modifying factor in radiation therapy. Amer. J. Roentgenol. 85, 803–815 (1961).PubMedGoogle Scholar
  51. Greenough, R.B.: Varying degrees of malignancy in cancer of the breast. J. Cancer Res. (Lancaster Pa.) 9, 454–463 (1924/25).Google Scholar
  52. Gricouroff, G.: Du pronostic histologique dans le cancer du sein. Bull. du cancer 35, 215 (1948).Google Scholar
  53. Gricouroff, G.: Sur l’état de différenciation morpholique des cellules cancéreuses dans les vaisseaux lymphatiques. C.R. Soc. Biol. (Paris) 147, 948 (1953).Google Scholar
  54. Gricouroff, G.: Sur la radiorésistance des cancers. Presse méd. 64, 137 (1956).PubMedGoogle Scholar
  55. Gricouroff, G., et F. Zadjela: Sur la teneur comparée en acide désoxyribonucléique des cellules cancéreuses, selon qu’elles sont attachées au stroma ou en migration dans les lymphatiques. C.R. Soc. Biol. (Paris) 147, 950 (1953).Google Scholar
  56. Griem, M.L., and F.D. Malkinson: Modification of radiation response of tissue by colchicine; preliminary clinical evaluation. 8th Internat. Cancer Congr., Moscow, 1962.Google Scholar
  57. Griem, M.L., and J.A. Stein: The effect of 1-Trijodothyronine on radiation sensitivity. Amer. J. Roentgenol. 84, 695–698 (1960).PubMedGoogle Scholar
  58. Guyer, M., and P.E. Claus: Irradiation of cancer following injection of colchicine. Proc. Soc. exp. Biol. (N.Y.) 42, 565 (1939).Google Scholar
  59. Hackmann, C.: Experimentelle Untersuchungen über die Wirkung von Actinomycin C (HBF 386) bei bösartigen Geschwülsten. Z. Krebsforsch. 58, 607 (1952).PubMedGoogle Scholar
  60. Heinecke, H.: Über die Einwirkung der Röntgenstrahlen auf innere Organe. Münch. med. Wschr. 51, 785 (1904).Google Scholar
  61. Herovici, C., et Cao. Xuanan: Signification pronostique des critères cytochimiques dans une série de 117 cancers du col utérin. Bull. Ass. franç. Cancer 45, 83–91 (1958).PubMedGoogle Scholar
  62. Holfelder, H: Die Röntgentherapie. Leipzig: G. Thieme 1935.Google Scholar
  63. Hollaender, A., W.K. Backer, and E.H. Anderson: Gold Spr. Harb. Symp. quant. Biol. 16 (1951).Google Scholar
  64. Holthusen, H.: Beiträge zur Biologie der Strahlenwirkung. Untersuchung an Askarideneiern. Pflügers Arch. ges. Physiol. 187, 1 (1921).Google Scholar
  65. Holthusen, H.: Über die Voraussetzungen für das Eintreten der Zellschädigung durch Röntgenstrahlen. Klin. Wschr. 4, 392 (1925).Google Scholar
  66. Holweck, F., et A. Lacassagne: Essai d’interprétation quantique des différentes lésions produites dans les cellules par les radiations. C.R. Soc. Biol. (Paris) 107, 814 (1931).Google Scholar
  67. Howard, A., and S.R. Pelc: Heredity (Suppl.) 6, 261 (1953).Google Scholar
  68. Howe, C.D., G.H. Fletcher, M.L. Samuels, and H.D. Suit: Combined 5-fluorouracil and cobalt irradiation evaluated by double blind technique. Acta Un. int. Cancr. 20, 400–403 (1964).PubMedGoogle Scholar
  69. Hyman, G.A.: The anemia of cancer. Amer. J. Roentgenol. 79, 511–520 (1958).PubMedGoogle Scholar
  70. Jolles, B., and P.C. Koller: Role of connective tissue in radiation reaction of tumours. Brit. J. Cancer 4, 77–89 (1950).PubMedGoogle Scholar
  71. Kaplan, H.S., and F.L. Howsden: Sensitization of purine-starved bacteria to X rays. Proc. nat. Acad. Sci. (Wash.) 51, 181–188 (1964).Google Scholar
  72. Kaplan, H.S., H.C. Smith, and P.A. Tomlin: Effect of halogenated pyrimidines on radiosensitivity of E. coli. Radiat. Res. 16, 98–113 (1962).Google Scholar
  73. Kaplan, H.S., R. Zavarine, and J. Earle: Interaction of the oxygen effect and radiosensitization produced by base analogues incorporated into deoxyribonucleic acid. Nature (Lond.) 194, 662–664 (1962).Google Scholar
  74. Koller, P.C.: Chromosome breakage. Progr. Biophys. 4, 195–243 (1954).Google Scholar
  75. Koller, P.C., and D.W. Smithers: Cytological analysis of the response of malignant tumors to irradiation as an approach to a biological basis for dosage in radiation therapy. Brit. J. Radiol. 19, 89–100 (1946).PubMedGoogle Scholar
  76. Kritter, H., et C. Herovici: Contribution à l’étude de la radiosensibilité des tumeurs utérines; critères cytochimiques. Bull. Ass. franç. Cancer 43, 513–521 (1956).PubMedGoogle Scholar
  77. Lacassagne, A.: Role de l’histologie dans l’appréciation de la radiosensibilité des cancers épithéliaux cutané et cutanéomuqueux. Paris méd. 43, 143–146 (1922).Google Scholar
  78. Lacassagne, A., et G. Gricouroff: Actions des radiation ionisantes sur l’organisme. Paris: Masson & Cie. 1956.Google Scholar
  79. Lacassagne, A., et O. Monod: Les caryocinèses atypiques provoquées dans les cellules cancéreuses par les rayons X et γ et leur rôle dans la régression des tumeurs malignes irradiées. Arch. franç. path. gén. exp. 1, fasc. I (1922).Google Scholar
  80. Langendorff, H.: Über das Wesen der Strahlenempfindlichkeit. Strahlenther. 78, 13 (1948).Google Scholar
  81. Langendorff, H., u. R. Koch: Untersuchungen über den biologischen Strahlenschutz. VI. Über die Absterbeordnung röntgenbestrahlter Mäuse. Strahlentherapie 94, 250 (1954).PubMedGoogle Scholar
  82. Levy, F.: Essai sur la théorie enzymatique du cancer. Prog. méd. (Paris) 83, 443–448 (1955).Google Scholar
  83. Loiseleur, J.: Synthèseschimiques consécutives à l’action des radiations ionisantes. J. de chim. phys. 52, 625 (1955).Google Scholar
  84. Lührs, W., E. Heise, and G. Bacigalupo: Influence of L-3,5,3′-triiodothyronine on oxidative phosphorylation of tumor mitochondria. Nature (Lond.) 183, 1534–1535 (1959).Google Scholar
  85. Maisin, H., et C. Fievez: Etude histologique de la réparation intestinale chez des rats irradiés sous diverses conditions de protection. Symposium de radiobiologie, Liège, 1954, S. 304.Google Scholar
  86. Maisin, J., H. Maisin, H. Dunjic et P. Moldaque: La radiobiologie comme méthode de travail en physiopathologie et en cancérologie expérimentale. Bull. Acad. suisse sci méd. 11, 247 (1955).Google Scholar
  87. Masson, P.: Tumeurs humaines. Paris: Maloine 1956.Google Scholar
  88. Miescher, G.: Röntgenbiologie der gesunden und kranken Haut. Strahlentherapie 27, 257 (1928).Google Scholar
  89. Mitchell, J.S.: Laboratory studies and clinical trials of some chronical radiosensitizers. Radio-biology Symp. 1954, p. 170–189. London: Butterworth’s Sci. Publ. 1954.Google Scholar
  90. Mottram, J.C.: Factor of importance in radio sensitivity of tumours. Brit. J. Radiol. 9, 606–614 (1936).Google Scholar
  91. Mottram, J.C.: Contribution of the spacing of radiation according to variation in radiosensitivity. Brit. J. Radiol. 10, 494 (1937).Google Scholar
  92. Nakahara, W.: Studies of x-ray effects. XIII. Histologie study of the fate of cancer grafts inoculated into an x-rayed area. J. exp. Med. 38, 309–326 (1923).PubMedCentralPubMedGoogle Scholar
  93. Paterson, R.: The treatment of malignant diseases by radium and X-rays. London: E. Arnold & Co. 1956.Google Scholar
  94. Perthes, G.: Über den Einfluß der Röntgenstrahlen auf epitheliale Gewebe, insbesondere auf das Carcinom. Langenbecks Arch. klin. Chir. 71, 955 (1903).Google Scholar
  95. Portman, U.-V.: Clinical therapeutic radiology. New York: Thomas Nelson & Sons 1950.Google Scholar
  96. Rajewsky, B.: Wissenschaftliche Grundlagen des Strahlenschutzes. Karlsruhe: C. Braun 1957.Google Scholar
  97. Regaud, C.: Fondements rationnels, indications techniques et résultats généraux de la radiothérapie des cancers. J. Radiol. Électrol. 4, 433 (1920).Google Scholar
  98. Regaud, C.: Sur la sensibilité du tissue osseux normal vis-à-vis des rayons X et γ et sur le mécanisme de l’ostéo-radionécrose. C.R. Soc. Biol. (Paris) 87, 629 (1922).Google Scholar
  99. Regaud, C., et R. Ferroux: Influence du „facteur temps“ sur la stérilisation des lignées cellulaires normales et néoplastiques par la radiothérapie. Acta radiol. (Stockh.), Suppl. 3, 107–123 (1929).Google Scholar
  100. Regaud, C., A. Lacassagne, and R. Ferroux: Fondements physiologiques et techniques de la radiothérapie des cancers. Rueil: A. Chahine 1925.Google Scholar
  101. Renfer, H.R.: Kombination von klinischer Behandlung mit Röntgenbestrahlung. Radiol. clin. (Basel) 18, 306–313 (1949).Google Scholar
  102. Russel-Carty, J.: Sensibilization to X-radiation by the direct electric current. 31, 414 (1938).Google Scholar
  103. Rutishauser, E., et G. Majno: L’irradiation préopératoire des carcinomes du sein. Constatations anatomo-pathologiques. Schweiz. med. Wschr. 77, 935–949 (1947).Google Scholar
  104. Scanlon, P.W.: The effect of mitotic suppression and recovery after irradiation on time-dose relationships and the application of this effect to clinical radiation therapy. Amer. J. Roentgenol. 81, 433–455 (1959).PubMedGoogle Scholar
  105. Scarff, R.W., and P.S. Andrews: The influence of histological structure on the radiosensitivity of tumours: a symposium. I. The histological aspects of tumour radiosensitivity. Brit. J. Radiol. 29, 478–482 (1956).PubMedGoogle Scholar
  106. Schinz, H.R., u. B. Slotopolsky: Strahlenbiologie der gesunden Haut. Ergebn. med. Strahlenforsch. 3, 583 (1928).Google Scholar
  107. Schober, R.: Mesenchymale Gewebsreaktionen am vorbestrahlten Mamma-Carcinom. Strahlentherapie 98, 366–381 (1955).PubMedGoogle Scholar
  108. Smithers, D.W.: Control and treatment of radiation reactions. Brit. J. Radiol. 15, 233–236 (1942).Google Scholar
  109. Spear, F.G.: Tissue culture II–III; its application to radiological research. Brit. J. Radiol. 8, 68, 280 (1935).Google Scholar
  110. Spear, F.G.: Radiations and living cells. New York: J. Wiley & Sons 1953.Google Scholar
  111. Stevens, L.G.: Injurious effects on the skin. Brit. med. J. 1896, 998.Google Scholar
  112. Strangeways, T.S.P., and H.E.M. Oakley: The immediate changes observed in tissue cells after exposure to soft X rays while growing in vitro. Proc. roy. Soc. B 95, 373–381 (1923).Google Scholar
  113. Sullivan, R.D., E. Miller, A.M. Wood, P. Clifford, J.K. Duff, R. Trussel, and J.H. Burchenal: Continous infusion cancer chemotherapy in humans — effects of therapy with intra-arterial methotrexate plus intermittent intramuscular citrovorum factor. Cancer Chemother. Rep. 10, 39–44 (1960).Google Scholar
  114. Thomlinson, R.H.: An experimental method for comparing treatments of intact malignant tumours in animals and its application to the use of oxygen in radiotherapy. Brit. J. Cancer 14, 555–576 (1960).PubMedGoogle Scholar
  115. Ultmann, J.E.: The role of the spleen in the hemolytic anemia of cancer patients. Cancer Res. 18, 959–967 (1958).PubMedGoogle Scholar
  116. Umiker, W., I. Lampe, and R. Rapp: The diagnostic and prognostic value of oral smears in the radiotherapy of carcinoma of the oral cavity and oropharynx. Amer. Roentgenol. 85, 69–77 (1961).Google Scholar
  117. Vintemberger, P.: Etudes expérimentales sur la mitose envisagée comme facteur de radiosensibilité. Arch. anat. 12, 229–464 (1930/31.)Google Scholar
  118. Warren, S.: The radiosensitivity of tumours. Amer. J. Roentgenol. 45, 641–650 (1941).Google Scholar
  119. Zuppinger, A.: Veränderungen nach protrahiert-fraktionierter Röntgenbestrahlung im Bereich der oberen Luft-und Speisewege. Strahlentherapie 70, 361–442 (1940).Google Scholar
  120. Zuppinger, A.: Die zweite protrahiert-fraktionierte Bestrahlung. Strahlentherapie 72, 562–616 (1943).Google Scholar
  121. Zuppinger, A.: The influence of Cortisone on the radiation effect of bones. Progr. biochem.Pharmacol. 1, 479–488 (1965).Google Scholar

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© Springer-Verlag Berlin Heidelberg 1967

Authors and Affiliations

  • R. Sarasin
  • G. Dulac

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