Advertisement

Der Internist pp 596-600 | Cite as

Die medikamentöse Therapie des Schwangerschaftshochdrucks

  • V. Friedberg
Chapter

Zusammenfassung

Hypertonie in der Schwangerschaft und Hypertonie infolge der Schwangerschaft beruhen auf unterschiedlichen pathophysiologischen Mechanismen. Ein kausal angreifendes Therapiekonzept sollte sich darauf beziehen, — wie es in der antihypertensiven Therapie im allgemeinen seit langem etabliert ist. Pharmakodynamisch müssen in der Schwangerschaft darüberhinaus beide Organismen — Mutter und Kind — berücksichtigt werden, da sie unterschiedlich reagieren können. Daher ist auch für die Hypertonie in der Schwangerschaft eine Revision des sonst sehr ausgeklügelten Therapiekonzepts erforderlich.

Schlüsselwörter

Schwangerschaftshypertonie Gestose Präeklampsie Pfropfgestose Alpha-methyldopa Beta-Blocker Dihydralazin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Blekta M, Hlavaty V, Trnkovä M, Bendl J, Bendova L, Chytil M (1970) Volume of whole blood and absolute amount of serum proteins in the early stage of late toxemia of pregnancy. Am J Obstet Gynecol 106:10PubMedGoogle Scholar
  2. 2.
    Campbell DM, Mac Gillivray I (1975) The effect of a low calorie diet or a thiazide diuretic on the incidence of preeclampsia and on birth weight. Br J Obstet Gynaecol 82:572PubMedCrossRefGoogle Scholar
  3. 3.
    Chesley LC (1972) Plasma and red cell volumes during pregnancy. Am J Obstet Gynecol 112:440PubMedGoogle Scholar
  4. 4.
    Cockburn J, Ounsted M, Moar VA, Redman CWG (1982) Final report of study on hypertension during pregnancy: the effects of specific treatment on the growth and development of the children. Lancet I:647CrossRefGoogle Scholar
  5. 5.
    Collins R, Yusuf S, Peto R (1985) Overview of randomised trial of diuretics in pregnancy. Br Med J [Clin Res] 290:17CrossRefGoogle Scholar
  6. 6.
    Cree JE, Meyer J, Hailey DM (1973) Diazepam in labours: its metabolism and effect on the clinical condition and thermogenesis of the newborn. Br Med J 4:251PubMedCentralPubMedCrossRefGoogle Scholar
  7. 7.
    Fidler J, Smith V, Fayers P, De Swiet M (1983) Randomized controlled comparative study of methyldopa and Oxprenolol in treatment of hypertension in pregnancy. Br Med [Clin Res] 286:1927CrossRefGoogle Scholar
  8. 8.
    Fievet P, Esper NE, Fournier A (1987) Comperative study of Clonidine and labetalol in severe hypotension induced by pregnancy. Clin Exp Hypertens [A] 6:244Google Scholar
  9. 9.
    Gallery EDM, Saunders DM, Hunyor SN, Gyory AZ (1591) Randomized comparison of methyldopa and Oxprenolol for treatment of hypertension in pregnancy. Br Med J [Clin Res] 1:1591CrossRefGoogle Scholar
  10. 10.
    Girndt I (1987) Hyper- und Hypotonie in der Schwangerschaft. VGH, WeinheimGoogle Scholar
  11. 11.
    Habib A, Mc Carthy JS (1977) Effects on the neonate of propranolol administered during pregnancy. J Pediatr 91:808PubMedCrossRefGoogle Scholar
  12. 12.
    Hansen J (1968) Alpha-methyl-dopa in the treatment of hypertension. Acta Med Scand 183:323PubMedCrossRefGoogle Scholar
  13. 13.
    Horvath JS, Phippard A, Korda A, Tiller DJ (1983) Clonidin Hydrochloride — A safe and effective antihypertensive agent in pregnancy. Clin Exp Hypertens 82:21Google Scholar
  14. 14.
    Kaulhausen R (1986) Vortrag anläßlich der Tagung der Schweizerischen Gynäkologengesellschaft. MünsterlingenGoogle Scholar
  15. 15.
    Lardoux H, Gerard J, Blazquez B, Chouty F, Flouvat B (1983) Hypertension in pregnancy : evaluation of two Betablockers atenolol and labetolol. Eur Heart J 4 [Suppl-G] 35PubMedCrossRefGoogle Scholar
  16. 16.
    Lean TH, Ratnam SS, Sivasamboo R (1968) Use of benzodiazepines in the management of eclampsia. J Obstet Gynäcol Br CommonwGoogle Scholar
  17. 17.
    Leather HM, Humphreys DM, Baker P, Chadd MA (1968) A controlled trial of hypotensive agents in hypertension in pregnancy. Lancet I1:488CrossRefGoogle Scholar
  18. 18.
    Liebermann BA, Stirrart GM, Cohen SL, Beard RW, Pinker GD, Belsey E (1978) The possible adverse effect of propranolol on the fetus in pregnancy compliated by severe Hypertension. Br J Obstet Gynaecol 85:678CrossRefGoogle Scholar
  19. 19.
    Lunnell NO, Nylund L, Lewander R, Sasby B (1982) Acute effects of an antihypertensive drug labetalol on utero placental blood flow. Br J Obstet Gynaecol 89:640CrossRefGoogle Scholar
  20. 20.
    Mabie WC, Pernoll ML, Biswas MK (1986) Chronic hypertension in pregnancy. Obstet Gynecol 67:197PubMedCrossRefGoogle Scholar
  21. 21.
    Murphy IF, O’Riordan J, Newcombe RG, Coles EC, Pearson JF (1986) Relation of haemoglobin levels in first and second trimester to outcome of pregnancy. Lancet I:992CrossRefGoogle Scholar
  22. 22.
    Cunningham FG, Pritchard SA (1984) The Parkland Memorial Hospital protocol for treatment of eclampsia : evaluation of 245 cases. J Obstet Gynecol 148:951CrossRefGoogle Scholar
  23. 23.
    Redman CWG, Beilin LJ, Bonnar J, Ounsted MK (1976) Fetal outcome in trial of antihypertensive treatment in pregnancy. Lancet II : 753CrossRefGoogle Scholar
  24. 24.
    Reynolds B, Butters L, Evans J, Adams T, Rubin PC (1984) First year of life after the use of atenolol in pregnancy associated hypertension. Arch Dis Child 59:161Google Scholar
  25. 25.
    Rubin PC, Butters L, Clard DM, Reynolds B, Sumner DJ, Steedman D, Low RA, Reid JL (1983) Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension. Lancet I:431Google Scholar
  26. 26.
    Sandstrom B (1978) Antihypertensive treatment with the adrenergic beta-receptor blocker metoprolol during pregnancy. Gynecol Obstet Invest 9:1985Google Scholar
  27. 27.
    De Swiet M (1985) Antihypertensive drugs in pregnancy. Br Med J 291:365CrossRefGoogle Scholar
  28. 28.
    Walker JJ, Erwin L, Lang G, Prentice CR, Belch JJ, McLaren M, Forbes CD, Calder AA (1982) Labetalol and platelet function in preeclampsia. Lancet II : 279CrossRefGoogle Scholar
  29. 29.
    Wallenburg HC (1986) Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia. Lancet I:1CrossRefGoogle Scholar
  30. 30.
    Walters BNJ, Redman CWG (1984) Treatment of severe pregnancy associated hypertension with the calcium antagonist nifedipine. Br J Obstet Gynaecol 91:330PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • V. Friedberg
    • 1
  1. 1.Universitäts-FrauenklinikMainzDeutschland

Personalised recommendations