Der Internist pp 372-389 | Cite as

Rezeptoren im Lipoprotein-Stoffwechsel

  • A. Steinmetz
  • G. Utermann


Heute werden neben dem etablierten und sehr gut definierten LDL-Rezeptorsystem mehrere weitere Rezeptoren im Lipoproteinstoffwechsel diskutiert, deren endgültige Darstellung noch aussteht: speziell der Apolipoprotein-E- oder Remnant-Rezeptor, der sogenannte Acetyl-LDL-Rezeptor als Rezeptor für modifizierte LDL, der High-Density-Lipoprotein-Rezeptor und der β-Very-Low-Density-Lipoprotein-Rezeptor. Die Daten über die letztgenannten Rezeptoren sind zum Teil noch kontrovers und erwarten eine endgültige Klärung in der Zukunft. Die vorliegende Übersicht hat das Ziel, sowohl die mittlerweile etablierten als auch die noch in der Diskussion sich befindenden Daten über die Lipoprotein-Rezeptorsysteme und ihre Liganden zusammenzufassen und ein Bild vom heutigen Verständnis darüber zu entwerfen.


Lipoproteinmeta-bolismus LDL-Rezeptor Apo-lipoproteine Arteriosklerose 


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  1. 1.
    Alaupovic P (1971) Apolipoproteins and lipoproteins. Atherosclerosis 13:141–146PubMedGoogle Scholar
  2. 2.
    Alpert AJ, Beaudet AL (1981) Apolipo-protein C-III-1 activates lysosomal sphingomyelinase in vitro. J Clin Invest 68:1592–1596PubMedCentralPubMedGoogle Scholar
  3. 3.
    Aisat E, Mandon F, Malassiné A, Rebourcet R, Goldstein S, Cedard L (1987) Identification of distinct receptors for native and acetylated-low-den-sity lipoprotein in human placental microvilli. Throphoblast Res 2:17–27Google Scholar
  4. 4.
    Angelin B, Raviola CA, Innerarity TL, Mahley RW (1983) Regulation of hepatic lipoprotein receptors in the dog. Rapid regulation of apo lipoprotein B, E receptors but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids. J Clin Invest 71:816–831PubMedCentralGoogle Scholar
  5. 5.
    Arbeeny CM, Rifici VA (1984) The uptake of chylomicron remnants and very low density lipoprotein remnants by the perfused rat liver. J Biol Chem 259:9662–9666PubMedGoogle Scholar
  6. 6.
    Avila EM, Holdswort G, Sasaki N, Jackson RL, Harmony JAK (1982) Apoprotein E suppresses the phytohe-magglutinin-activated phospholipid turnover in peripheral blood mononuclear cells. J Biol Chem 257:5900–5909PubMedGoogle Scholar
  7. 7.
    Baker DP, Van Lenten BJ, Fogelman AM, Edwards PA, Kean C, Berliner JA (1983) LDL, scavenger, and β-VLDL receptors on aortic endothelial cells. Arteriosclerosis 4:248–255Google Scholar
  8. 8.
    Barbaras R, Grimaldi P, Negrel R, Ailhaud G (1986) Characterization of high-density lipoprotein binding and cholesterol efflux in cultured mouse adipose cells. Biochim Biophys Acta 888:143–146PubMedGoogle Scholar
  9. 9.
    Barbaras R, Puchois P, Grimaldi P, Barkia A, Fruchart J-C, Ailhaud G (1987) Relationship in adipose cells between the presence of receptor sites for high density lipoproteins and the promotion of reverse cholesterol transport. Biochem Biophys Res Commun 149:545–554PubMedGoogle Scholar
  10. 10.
    Barbaras R, Puchois P, Fruchart J-C, Ailhand G (1987) Cholesterol efflux from cultured adipose cells is mediated by Lp AI particles but not Lp AI: All particles. Biochem Biophys Res Commun 142:63–69PubMedGoogle Scholar
  11. 11.
    Basu SK, Brown MS, Ho YK, Havel RJ, Goldstein JL (1981) Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. Proc Natl Acad Sci USA 78:7545–7549Google Scholar
  12. 12.
    Basu SK, Goldstein JL, Anderson RGW, Brown MS (1976) Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercho-lesterolemic fibroblasts. Proc Natl Acad Sci USA 73:3178–3182PubMedGoogle Scholar
  13. 13.
    Basu SK, Ho YK, Brown MS, Bilheimer DW, Anderson RGW, Goldstein JL (1982) Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes. J Biol Chem 257:9788–9795PubMedGoogle Scholar
  14. 14.
    Beisiegel U, Weber W, Havinga JR, Ihrke G, Hui DY, Wernette-Hammond ME, Turck CW, Innerarity TL, Mahley RW (1988) Apolipoprotein E-binding proteins isolated from human liver. Arteriosclerosis (in press)Google Scholar
  15. 15.
    Benditt EP, Eriksen N (1977) Amyloid protein SAA is associated with high density lipoprotein from human serum. Proc Natl Acad Sci USA 74:4025–4028PubMedGoogle Scholar
  16. 16.
    Bersot TP, Innerarity TL, Mahley RW, Havel RJ (1983) Cholesteryl ester accumulation in mouse peritoneal macrophages induced by β-migrating very low density lipoproteins from patients with atypical dysbetalipoproteinemia. J Clin Invest 72:1024–1033PubMedCentralPubMedGoogle Scholar
  17. 17.
    Biesbrock R, Oram JF, Albers JJ, Bier-man EL (1983) Specific high affinity binding of high density lipoprotein to cultured human skin fibroblasts and arterial smooth muscle cells. J Clin Invest 71:525–539Google Scholar
  18. 18.
    Bilheimer DW, Eisenberg S, Levy RI (1971) Abnormal metabolism of very low density lipoproteins in type III. Circulation 44:11–56Google Scholar
  19. 19.
    Bilheimer DW, Goldstein JL, Grundy SM, Starzl TE, Brown MS (1984) Liver transplantation to provide low density lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. N Engl J Med 311:1658–1664PubMedCentralPubMedGoogle Scholar
  20. 20.
    Blomhoff R, Drevon CA, Eskild W, Helgerud P, Norum KR, Berg K (1984) Clearence of acetyl low density lipoprotein by rat liver endothelial cells. Implications for hepatic cholesterol metabolism. J Biol Chem 259:8898–8903PubMedGoogle Scholar
  21. 21.
    Brinton EA, Oram JF, Chen CH, Albers J J, Bierman EL (1986) Binding of high density lipoprotein to cultured fibroblasts after chemical alteration of apoprotein amino acid residues. J Biol Chem 261:495–503PubMedGoogle Scholar
  22. 22.
    Brown MS, Anderson RGW, Goldstein JL (1983) Recycling receptors: The round-trip itinerary of migrant membrane proteins. Cell 32:663–667PubMedGoogle Scholar
  23. 23.
    Brown MS, Basu SK, Falck JR, Ho YK, Goldstein JL (1980) The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages. J Su-pramolec Struct 13:67–81Google Scholar
  24. 24.
    Brown MS, Dana SE, Goldstein JL (1973) Regualtion of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. Proc Natl Acad Sci USA 70:2162–2166PubMedGoogle Scholar
  25. 25.
    Brown MS, Dana SE, Goldstein JL (1974) Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts: Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J Biol Chem 249:789–796PubMedGoogle Scholar
  26. 26.
    Brown MS, Goldstein JL (1974) Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglu-taryl coenzyme A reductase activity. Proc Natl Acad Sci USA 71:788–792PubMedGoogle Scholar
  27. 27.
    Brown MS, Goldstein JL (1975) Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Cell 6:307–316PubMedGoogle Scholar
  28. 28.
    Brown MS, Goldstein JL (1983) Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem 52:223–261PubMedGoogle Scholar
  29. 29.
    Brown WV, Baginski ML (1972) Inhibition of lipoprotein lipase by an apoli-poprotein of human very low density lipoprotein. Biochem Biophys Res Commun 46:375–382PubMedGoogle Scholar
  30. 30.
    Carella M, Cooper AD (1979) High affinity binding of chylomicron remnants to rat liver plasma membranes. Proc Natl Acad Sci USA 76:338–342Google Scholar
  31. 31.
    Carew TE, Schwenke DC, Steinberg D (1987) Antiatherogenic effect of probu-col unrelated to its hypocholesterolem-ic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macro-phage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 84:7725–7729PubMedGoogle Scholar
  32. 32.
    Chacko GK (1985) Characterization of high density lipoprotein binding sites in rat liver and testis membranes. J Lipid Res 26:745–754PubMedGoogle Scholar
  33. 33.
    Chait A, Bierman EL, Albers JJ (1978) Regulatory role of insulin in the degradation of low density lipoprotein by cultured human skin fibroblasts. Bio-chim Biophys Acta 529:292–299Google Scholar
  34. 34.
    Chait A, Bierman EL, Albers JJ (1979) Low Density lipoprotein receptor activity in cultured human skin fibroblasts, mechanism of insulin-induced stimulation. J Clin Invest 64:1309–1319PubMedCentralPubMedGoogle Scholar
  35. 35.
    Chait A, Ross R, Albers JJ, Bierman EL (1980) Platelet-derived growth factor stimulates activity of low density lipoprotein receptors. Proc Natl Acad Sci USA 77:408–4088Google Scholar
  36. 36.
    Chao YS, Windier EE, Chen GC, Havel RJ (1979) Hepatic catabolism of rat and human lipoproteins in rats treated with 17 a-ethinyl estradiol. J Biol Chem 254:11360–11366PubMedGoogle Scholar
  37. 37.
    Chen CH, Albers JJ (1985) Activation of lecithin: cholesterol acyltransferase by apolipoproteins E-2, E-3 and A-IV isolated from human plasma. Biochim Biophys Acta 836:279–285PubMedGoogle Scholar
  38. 38.
    Cheung MC, Albers JJ (1984) Characterization of lipoprotein particles isolated by immunoaffinity chromatography. Particles containing A I and A II and particles containing A I but no A IL J Biol Chem 259:12201–12209PubMedGoogle Scholar
  39. 39.
    Cheung MC, Wolf AC, Lum KD, Tollefson JH, Albers JJ (1986) Distribution and localization of lecithin: cholesterol acyltransferase and cholesteryl ester transferactivity in A I-containing lipoproteins. J Lipid Res 27:1135–1140PubMedGoogle Scholar
  40. 40.
    Cummings RD, Kornfeld S, Schneider WJ, Hohgood KK, Tolleshaug H, Brown MS, Goldstein JL (1983) Biosynthesis of the N- and O-linked oligo-saccarides of the low density lipoprotein receptor. J Biol Chem 258:15261–15273PubMedGoogle Scholar
  41. 41.
    Davis CG, Elhammer A, Russel DW, Schneider WJ, Kornfeld S, Brown MS, Goldstein JL (1986) Deletion of clustered o-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts. J Biol Chem 261:2828–2838PubMedGoogle Scholar
  42. 42.
    Davis CG, Lehrman MA, Russell DW, Anderson RGW, Brown MS, Goldstein JL (1986) The J.D. mutation in familial hypercholesterolemia: Amino-acid substitution in cytoplasmatic domain impedes internalization of LDL receptors. Cell 45:15–24PubMedGoogle Scholar
  43. 43.
    Dresel HA, Friedrich E, Via DP, Schettler G, Sinn H (1985) Characterization of binding sites for acetylated low density lipoprotein in the rat liver in vivo and in vitro. EMBO J 4:1157–1162PubMedGoogle Scholar
  44. 44.
    Dresel HA, Friedrich E, Via DP, Sinn H, Ziegler R, Schettler G (1987) Binding of acetylated low density lipoprotein and maleylated bovine serum albumin to the rat liver: one or two receptors? EMBO J 6:319–326PubMedGoogle Scholar
  45. 45.
    Dresel HA, Otto I, Weigel H, Schettler G, Via DP (1984) A simple and rapid anti-ligand enzyme immunoassay for visualization of low-density lipoprotein membrane receptors. Biochim Biophys Acta 795:452–257PubMedGoogle Scholar
  46. 46.
    Dvorin E, Gorder NL, Benson DM, Gotto AM jr (1986) Apolipoprotein A-IV A determinant for binding and uptake of high density lipoproteins by rat hepatocytes. J Biol Chem 261:15714–15718PubMedGoogle Scholar
  47. 47.
    East CA, Grundy SM, Bilheimer DW (1986) Preliminary report: Treament of Type III hyperlipoproteinemia with mevinolin. Metabolism 35:97–98PubMedGoogle Scholar
  48. 48.
    Endo A, Kuroda M, Tanzawa K (1976) Competitive inhibition of 3-hydroxy-3-methylglutoyl coenzyme A reductase by ML-236 A and ML 236 B fungal metabolites having hypocholestero-laemic activitis. FEBS Lett 72:323–330PubMedGoogle Scholar
  49. 49.
    Fainaru M, Mahley RW, Hamilton RL, Innerarity TL (1982) Structural and metabolic heterogeneity of β-very low density lipoproteins from cholesterol-fed dogs and from humans with type III. J Lipid Res 23:702–704PubMedGoogle Scholar
  50. 50.
    Fidge NH (1986) Partial purification of a high density lipoprotein-binding protein from rat liver and kidney membranes. FEBS Lett 199:265–268PubMedGoogle Scholar
  51. 51.
    Fidge NH, Kagami A, O’Connor M (1985) Identification of a high density lipoprotein binding protein from adrenocortical membranes. Biochem Biophys Res Commun 129:759–765PubMedGoogle Scholar
  52. 52.
    Fidge NH, Nestel PJ (1985) Identification of apolipoproteins involved in the interaction of human high density lipoprotein3 with receptors on cultured cells. J Biol Chem 260:3570–3575PubMedGoogle Scholar
  53. 53.
    Fielding CJ, Shore VG, Fielding PE (1972) A protein cofactor of lecithin: cholesterol acyltransferase. Biochem Biophys Res Commun 46:1493–1498PubMedGoogle Scholar
  54. 54.
    Fogelman AM, Haberland ME, Saeger J, Hokom M, Edwards PA (1981) Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages. J Lipid Res 22:1131–1141PubMedGoogle Scholar
  55. 55.
    Fogelman AM, Saeger J, Haberland ME, Hokom E, Tanaka R, Edwards PA (1982) Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation. Proc Natl Acad Sci USA 79:922–926PubMedGoogle Scholar
  56. 56.
    Fogelman AM, Shechter I, Saeger J, Hokom M, Child JS, Edwards PA (1980) Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proc Natl Acad Sci USA 77:2214–2218PubMedGoogle Scholar
  57. 57.
    Fong BS, Rodrigues PO, Salter AM, Yip BP, Despress JP, Gregg RE, Angel A (1985) Characterization of high density lipoprotein binding to human adipocyte plasma membranes. J Clin Invest 75:1804–1812PubMedCentralPubMedGoogle Scholar
  58. 58.
    Fong LG, Parthasarathy S, Witztum JL, Steinberg D (1987) Nonenzamatic oxidative cleavage of peptide bonds in apoprotein B-100. J Lipid Res 28:1466–1477PubMedGoogle Scholar
  59. 59.
    Francke U, Brown MS, Goldstein JL (1984) Assingment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand and a genetic disease. Proc Natl Acad Sci USA: 81:2826–2830PubMedGoogle Scholar
  60. 60.
    Fredrickson DS, Levy RI, Lindgren FT (1968) A comparison of heritable abnormal lipoprotein pattens as defined by two different techniques. J Clin Invest 47:2446–2457PubMedCentralGoogle Scholar
  61. 61.
    Gal D, Mac Donald PC, Porter JC, Simpson ER (1982) Cholesterol metabolism in cancer cells in monolayer culture. IV: Metabolism of high density lipoproteins. Arch Biochem Biophys 214:726–733PubMedGoogle Scholar
  62. 62.
    Gewers W, Casciola LAF, Fourie AM, Sanan DA, Coetzee GA, van der Westhuyzen DR (1987) Defective LDL receptors that are common in a large population. Familial hypercholestero-laemia in South Africa. Biol Chem Hoppe-Seyler 368:1233–1243Google Scholar
  63. 63.
    Ghiselli C, Crump WL III, Gotto AM jr (1986) Binding of apo A IV-phos-pholipid complexes to plasma membranes of rat liver. Biochem Biophys Res Commun 139:122–128PubMedGoogle Scholar
  64. 64.
    Gianturco SH, Bradley WA, Gotto AM jr., Morrisett JD, Peavy DL (1982) Hypertriglyceridemic very low density lipoproteins induce triglyceride synthesis and accumulation in mouse peritoneal macrophages. J Clin Invest 70:168–178PubMedCentralPubMedGoogle Scholar
  65. 65.
    Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS (1985) Membrane-bound domanin of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell 41:249–258PubMedGoogle Scholar
  66. 66.
    Glass C, Pittman RC, Civen M, Steinberg D (1985) Uptake of high-density lipoprotein-associated apoprotein A-I and cholesterol esters by 16 tissues of the rat in vivo and by adrenal cells and hepatocytes in vitro. J Biol Chem 260:744–750PubMedGoogle Scholar
  67. 67.
    Glass C, Pittman RC, Weinstein DB, Steinberg D (1983) Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: Selective delivery of cholesterol ester to liver, adrenal, and gonad. Proc Natl Acad Sci USA 80:5435–5439PubMedGoogle Scholar
  68. 68.
    Glomset JA (1968) The plasma lecithin-cholesterol acyltransferase reaction. J Lipid Res 9:155–167PubMedGoogle Scholar
  69. 69.
    Goldstein JL, Brown MS (1973) Familial hypercholesterolemia: Identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proc Natl Acad Sci USA 70:2804–2808PubMedGoogle Scholar
  70. 70.
    Goldstein JL, Brown MS (1977) The low density lipoprotein pathway and its relation to arteriosclerosis. Annu Rev Biochem 46:897–930PubMedGoogle Scholar
  71. 71.
    Goldstein JL, Brown MS, Anderson RGW, Russell DW, Schneider WJ (1985) Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system. Annu Rev Cell Biol 1:1–39PubMedGoogle Scholar
  72. 72.
    Goldstein JL, Ho YK, Basu SK, Brown MS (1979) Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA 76:333–337PubMedGoogle Scholar
  73. 73.
    Goldstein JL, Ho YK, Brown MS, Innerarity TL, Mahley RW (1980) Cho-lesteryl ester accumulation in macrophages resulting from receptor mediated uptake and degradation of hyper-cholesterolemic canine β-very low density lipoproteins. J Biol Chem 255:1839–1848PubMedGoogle Scholar
  74. 74.
    Graham DL, Oram JF (1987) Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting. J Biol Chem 262:7439–7442PubMedGoogle Scholar
  75. 75.
    Gwynne JT, Hess B (1980) The role of high density lipoproteins in rat adrenal cholesterol metabolism and steroidogenesis. J Biol Chem 255:10875–10883PubMedGoogle Scholar
  76. 76.
    Gwynne JT, Mahaffee DD (1987) Esterification of cholesterol in high density lipoprotein decreases its ability to support ACTH-stimulated steroidogenesis by rat adrenocortical cells. J Biol Chem 262:16349–16356PubMedGoogle Scholar
  77. 77.
    Gwynne JT, Mahaffee DD, Brewer HB jr., Ney RL (1976) Adrenal cholesterol uptake from plasma lipoproteins: Regulation by corticotropin. Proc Natl Acad Sci USA 73:4329–4333PubMedGoogle Scholar
  78. 78.
    Habenicht AJR, Dresel HA, Goerig M, Weber J-A, Stoehr M; Glomset JA, Ross R, Schettler G (1986) Low density lipoprotein receptor-dependent prostaglandin synthesis in Swiss 3T3 cells stimulated by platelet-derived growth factor. Proc Natl Acad Sci USA 83:1344–1348PubMedGoogle Scholar
  79. 79.
    Havekes L, Mommaas-Kienhuis AM, Schouten D, De Wit E, Scheffer M, van Hinsbergh VWM (1985) High affinity uptake and degradation of acetylated low density lipoprotein by confluent human vascular endothelial cells. Arteriosclerosis 56:81–92Google Scholar
  80. 80.
    Havekes L, Shouton D, van Hinsbergh V, de Wit E (1984) Characterization of the binding of apolipoprotein E-free high density lipoprotein to cultured human endothelial cells. Biochem Biophys Res Commun 122:785–790PubMedGoogle Scholar
  81. 81.
    Havel RJ, Eder HA, Bragdon J (1955) The distribution and chemical compositum of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34:1345–1353PubMedCentralPubMedGoogle Scholar
  82. 82.
    Havel RJ, Shore VG, Shore B, Bier DM (1970) role of specific glycopep-tides of human serum lipoproteins in the activation of lipoprotein lipase. Circ Res 27: 595–600PubMedGoogle Scholar
  83. 83.
    Hazzard WR, Bierman EL (1971) Impaired removal of very low density lipoprotein (VLDL) “remnants” in the pathogenesis of broad beta disease (type III hyperlipoproteinemia). Clin Res 19:476Google Scholar
  84. 84.
    Hazzard WR, Bierman EL (1976) Delayed clearance of chylomicron remnants following vitamin-A-containing oral fat loads in broad-beta disease (type III Hyperlipoproteinemia). Metabolism 25:777–801PubMedGoogle Scholar
  85. 85.
    Henriksen T, Mahoney EM, Steinberg D (1981) Enhanced macrophage degradation of LDL previously incubated with cultured endothelial cells: Recognition by receptors for acetylated-LDL. Proc Natl Acad Sci USA 78:6499–6503PubMedGoogle Scholar
  86. 86.
    Hoeg JM, Demosky SJ jr, Edge SB, Gregg RE, Osborne JC jr, Brewer HB jr (1985) Characterization of a human hepatic receptor for high density lipoproteins. Arteriosclerosis 5:228–237PubMedGoogle Scholar
  87. 87.
    Hoeg JM, Demosky SJ, Gregg RE, Schaefer EJ, Brewer HB jr (1985) Distinct heaptic receptors for low density lipoproteins and apolipoprotein E in humans. Science 227:759–761Google Scholar
  88. 88.
    Ho YK, Brown MS, Goldstein JL (1980) Hydrolysis and excretion of cytoplasmatic cholesterol esters by macrophages: stimulation by high density lipoproteins and other agents. J Lipid Res 21:391–398PubMedGoogle Scholar
  89. 89.
    Ho YK, Brown MS, Bilheimer DW, Goldstein JL (1976) Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes. J Clin Invest 58:1465–1474PubMedCentralPubMedGoogle Scholar
  90. 90.
    Hobbs HH, Brown MS, Russell DW, Davignon J, Goldstein JL (1987) Deletion in the gene for the low-density-li-poprotein receptor in a majority of french Canadians with familial hypercholesterolemia. N Engl J Med 317:734–737PubMedGoogle Scholar
  91. 91.
    Hui DY, Brecht WJ, Hall EA, Friedman G, Innerarity TL, Mahley RW (1986) Isolation and Characterization of the apolipoprotein E receptor from canine and human liver. J Biol Chem 261:4256–4267PubMedGoogle Scholar
  92. 92.
    Hui DY, Innerarity TL, Mahley RW (1981) Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B, E receptors. J Biol Chem 256:5646–5655Google Scholar
  93. 93.
    Hui DY, Innerarity TL, Mahley RW (1984) Defective hepatic lipoprotein receptor binding of ß-very low density lipoproteins from type III hyperlipopro-teinemic patients. Importance of apolipoprotein E. J Biol Chem 259:860–869Google Scholar
  94. 94.
    Hui DY, Innerarity TL, Milne RW, Marcel YL, Mahley RW (1984) Binding of chylomicron remnants and ß-very low density lipoproteins to hepatic and extrahepatic receptors. A process independent of apolipoprotein B 48. J Biol Chem 259:15060–15068PubMedGoogle Scholar
  95. 95.
    Humphries SE (1986) Familial hyper-cholesterolaemia as an example of early diagnosis of coronary artery disease risk by DNA techniques. Br Heart J 56:201–205PubMedCentralPubMedGoogle Scholar
  96. 96.
    Hwang J, Menon KMJ (1985) Binding of Apolipoprotein A-I and A-II after recombination with phospholipid vesicles to the high density lipoprotein receptor of luteinized rat ovary. J Biol Chem 260:5660–5668PubMedGoogle Scholar
  97. 97.
    Innerarity TL, Arnold KS, Weisgraber KH, Mahley RW (1986) Apolipoprotein E is the determinant that mediates the receptor uptake of /?-very low density lipoproteins by mouse macrophages. Arteriosclerosis 6:114–122PubMedGoogle Scholar
  98. 98.
    Innerarity TL, Mahley RW (1980) Lipoprotein metabolism mediated by cell surface receptors: In vivo and in vitro parallels. In: Fumigalli R, Kritchevski D, Paoletti R (eds) Drugs affecting lipid metabolism. Elsevier Amsterdam, pp 53–60Google Scholar
  99. 99.
    Innerarity TL, Pitas RE, Mahley RW(1979) Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J Biol Chem 254:4186–4190PubMedGoogle Scholar
  100. 100.
    Kagami A, Fidge N, Suzuki N, Nestel P (1984) Characteristics of the binding of high density lipoprotein3 by intact cells and membrane preparations of rat intestinal mucosa. Biochim Biophys Acta 795:179–190PubMedGoogle Scholar
  101. 101.
    Karlin JB, Johnson WJ, Benedict CR, Chacko GK, Phillips MC, Rothblat GH (1987) Cholesterol flux between cells and high density lipoprotein. Lack of relationship to specific binding of the lipoprotein to cell surface. J Biol Chem 262:12557–12564PubMedGoogle Scholar
  102. 102.
    Kesäniemi YA, Witztum JL, Steinbrecher UP (1983) Receptor mediated catabolism of LDL in man. J Clin Invest 71:950–959PubMedCentralPubMedGoogle Scholar
  103. 103.
    Kita T, Brown MS, Bilheimer DW, Goldstein JL (1982) Delayed clearance of very low density lipoprotein in WHHL rabbits. Proc Natl Acad Sci USA 79:5693–5697PubMedGoogle Scholar
  104. 104.
    Kita T, Goldstein JL, Brown MS, Wa-tanabe Y, Hornick CA, Havel RJ (1982) Hepatic uptake of chylomicron remnants in WHHL rabbits: A mechanism genetically distinct from the low density lipoprotein receptor. Proc Natl Acad Sci USA 79:3623–3627PubMedGoogle Scholar
  105. 105.
    Kita T, Nagano Y, Yokode M, Ishiik, Kume N, Ooshima A, Yoshida H, Kawai C (1987) Probucol prevents the progression of arteriosclerosis in Wa-tanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci USA 84:5928–5931PubMedGoogle Scholar
  106. 106.
    Knight BL, Soutar AK (1982) Changes in the metabolism of modified and unmodified low-density lipoproteins during maturation of cultured blood monocyte-macrophages from normal and homozygous familial hypercholes-terolaemic subjects. Eur J Biochem 125:407–413PubMedGoogle Scholar
  107. 107.
    Konishita M, Teramoto T, Kato H, Hashimoto Y, Naito C, Toda G, Oka H (1985) Partial purification of the apolipoprotein E receptor of rat liver membrane. J Biochem (Tokyo) 97:1803–1806Google Scholar
  108. 108.
    Koo C, Wernette-Hammond ME, Innerarity TL (1986) Uptake of canine β-very low density lipoproteins by mouse peritoneal macrophages is mediated by a low density lipoprotein receptor. J Biol Chem 261:11194–11201PubMedGoogle Scholar
  109. 109.
    Koren E, Puchois P, Alaupovic P, Fesmire J, Kandoussi A, Fruchart JC (1987) Quantitation of two different types of apoprotein A I containing lipoprotein particles in plasms by enzyme linked differential antibody immunosorbent assay. Clin Chem 33:38–43PubMedGoogle Scholar
  110. 110.
    Kovanen PT, Basau SK, Goldstein JL, Brown MS (1979) Low density lipoprotein binding to membranes prepared from fresh tissue. Endocrinology 104:610–616PubMedGoogle Scholar
  111. 111.
    Kovanen PT, Brown MS, Goldstein JL (1979) Increased binding of low density lipoprotein to liver membranes from rats treated with 17 α-ethinyl estradiol. J Biol Chem 254:11367–11373PubMedGoogle Scholar
  112. 112.
    La Rosa JL, Levy RI, Herbert PN, Lux SE, Frederikson DS (1970) A specific apoprotein activator for lipoprotein lipase. Biochem Biophys Res Commun 41:57–62Google Scholar
  113. 113.
    Lehrman MA, Goldstein JL, Brown MS, Russell DW, Schneider WJ (1985) Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmatic domain. Cell 41:735–743PubMedGoogle Scholar
  114. 114.
    Lehrman MA, Schneider WJ, Brown MS, Davis CG, Elhammer A, Russell DW, Goldstein JL (1987) The Lebanese allele at the low density lipoprotein receptor locus: nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum. J Biol Chem 262:401–410PubMedGoogle Scholar
  115. 115.
    Lehrman MA, Schneider WJ, Südhof TC, Brown MS, Goldstein JL, Russell DW (1985 a) Mutation in the LDL receptor: Alu-Alu recombination deletes exons endcoding transmembrane and cytoplasmic domains. Science 227:140–146PubMedGoogle Scholar
  116. 116.
    Lindqvist P, Ostlund-Lindqvist AM, Witztum JL, Steinberg D, Little JA (1983) The role of lipoprotein lipase in the metabolism of triglyceride rich lipoproteins by macrophages. J Biol Chem 258:9086–9092PubMedGoogle Scholar
  117. 117.
    Luskey KL, Faust JR, Chin DJ, Brown MS, Goldstein JL (1983) Amplification of the gene fore 3-hydroxy-3-methyl-glutaryl coenzyme. A reductase but not for the 53 kDa-protein, in UT-1 cells. J Biol Chem 258:8462–8469PubMedGoogle Scholar
  118. 118.
    Mahley (1978) Alterations in plasma lipoproteins induced by cholesterol feeding in animals including man. In: Dietschy JM, Gotto AM jr, Ontko JA (eds) disturbances in lipid and lipoprotein metabolism Clinical Physiology Series. American Physiological Society, Bethesda, MD, 181–197Google Scholar
  119. 119.
    Mahley RW, Hui DY, Innerarity TL, Weisgraber KH (1981) Two independent lipoprotein receptors on hepatic membranes of the dog, swine and man. Apo-B, E and apo-E receptors. J Clin Invest 68:1197–1206PubMedCentralPubMedGoogle Scholar
  120. 120.
    Mahley RW, Innerarity TL (1983) Lipoprotein receptors and cholesterol homeostasis. Biochim Biophys Acta 737:197–222PubMedGoogle Scholar
  121. 121.
    Mahley RW, Innerarity TL, Brown MS, Ho YK, Goldstein JL (1980) Cho-lesteryl ester synthesis in macrophages: Stimulation by β-very low density lipoproteins from cholesterol-fed animals of several species. J Lipid Res 21:970–980PubMedGoogle Scholar
  122. 122.
    Mahley RW, Innerarity TL, Pitas RE, Weisgraber KH, Brown JH, Gross E (1977) Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of ar-ginyl residues in arginine-rich and B apoproteins. J Biol chem 252:7279–2787PubMedGoogle Scholar
  123. 123.
    Mazzone T, Lopez C, Bergstraesser L (1987) Modification of very low density lipoproteins leads to macrophage scavenger receptor uptake and cholesteryl ester deposition. Arteriosclerosis 7:191–196PubMedGoogle Scholar
  124. 124.
    Mendel CM, Kunitake ST, Kane JP, Kemper ES (1988) Radiation inactiva-tion of binding sites for high density lipoproteins in human fibroblast membranes. J Biol Chem 263:1314–1319PubMedGoogle Scholar
  125. 125.
    Miller GJ, Miller NE (1975) Plasma-high density lipoprotein concentration and development of ischaemic heart-disease. Lancet 97:16–19Google Scholar
  126. 126.
    Miller NE, La Ville A, Crook D (1985) Direct evidence that reverse cholesterol transport is mediated by high density lipoprotein in rabbit. Nature 314:109–111PubMedGoogle Scholar
  127. 127.
    Milne RW, Marcel YL (1985) The use of monoclonal antibodies to probe human apolipoprotein B structure and function. Can J Biochem Cell Biol 63:906–912PubMedGoogle Scholar
  128. 128.
    Mjös OD, Faergeman O, Hamilton RL, Havel RJ (1975) Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat. J Clin Invest 56:603–615PubMedCentralPubMedGoogle Scholar
  129. 129.
    Monaco L, Bond HM, Howell KE, Cortese R (1987) A recombinant apo A-1-protein A hybrid reproduces the binding parameters of HDL to its receptor. EMBO J 6:3253–3260PubMedGoogle Scholar
  130. 130.
    Nagelkerke JF, Barto KP, van Berkel TJC (1983) In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. J Biol Chem 258:12221–12227PubMedGoogle Scholar
  131. 131.
    Nestler JE, Chacko GK, Strauss JF III (1985) Stimulation of rat ovarian cell steroidogenesis by high density lipoproteins modified with tetranitrometh-ane. J Biol Chem 260:7316–7321PubMedGoogle Scholar
  132. 132.
    Oppenheimer MJ, Oram JF, Bierman EL (1987) Downregulation of high density lipoprotein receptor activity of cultured fibroblasts by platelet-derived growth factor. Arteriosclerosis 7:325–332PubMedGoogle Scholar
  133. 133.
    Oram JF, Brinton EA, Bierman EL (1983) Regulation of high density lipoprotein receptor activity in cultured human skin fibroblasts and human arterial smooth muscle cells. J Clin Invest 72:1611–1621PubMedCentralPubMedGoogle Scholar
  134. 134.
    Oram JF, Johnson CJ, Aulinskas-Brown T (1987) Interaction of high density lipoprotein with its receptor on cultured fibroblasts and macrophages. Evidence for reversable binding at the cell surface without internalization. J Biol Chem 262:2405–2410PubMedGoogle Scholar
  135. 135.
    Packard CJ, Boag DE, Clegg RJ, Bedford D, Shepherd J (1985) Effects of 1,2 cyclohexanedione modification on the metabolism of VLDL apolipoprotein B. Lipid Res 26:1058–1067Google Scholar
  136. 136.
    Parthasarathy S, Fong LG, Otero D, Steinberg D (1987) Recognition of so-lubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor. Proc Natl Acad Sci USA 84:537–540PubMedGoogle Scholar
  137. 137.
    Parthasarathy S, Steinbrecher UP, Bar-nett J, Witztum JL, Steinberg D (1985) Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein. Proc Natl Acad Sci USA 82:3000–3004PubMedGoogle Scholar
  138. 138.
    Parthasarathy S, Young SG, Witztum JL, Pittman RC, Steinberg D (1986) Probucol inhibits oxidative modification of low density lipoprotein. J Clin Invest 77:641–644PubMedCentralPubMedGoogle Scholar
  139. 139.
    Phillips MC, Johnson WJ, Rothblat GH (1987) Mechanisms and consequences of cellular cholesterol exchange and transfer. Biochim Biophys Acta 906:223–276PubMedGoogle Scholar
  140. 140.
    Pitas RE, Boyles JK, Lee SH, Hui D, Weisgraber KH (1987) Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B, E (LDL) receptors in the brain. J Biol Chem 262:14352–14360Google Scholar
  141. 141.
    Pitas RE, Boyles J, Mahley RW, Bissell DM (1985) Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol 100:103–117PubMedGoogle Scholar
  142. 142.
    Pitas RE, Innerarity TL, Mahley RW (1983) Foam cells in expiants of atherosclerotic rabbit aortas have receptors for β-very low density lipoprotein and modified low density lipoprotein. Arteriosclerosis 3:2–12PubMedGoogle Scholar
  143. 143.
    Pittman RC, Carew TE, Attie AD, Witztum Y, Watanabe Y, Steinberg D (1982) Receptor-dependent and receptor independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits. J Biol Chem 257:7994–8000PubMedGoogle Scholar
  144. 144.
    Pittman RC, Glass CK, Atkinson D, Small DM (1987) Synthetic high density lipoprotein particles. Application to studies of the apoprotein specificity for selective uptake of cholesterol esters. J Biol Chem 262:2435–2442PubMedGoogle Scholar
  145. 145.
    Pittman RC, Knecht TP, Rosenbaum MS, Taylor CA jr (1987) A nonendocy-totic mechanism for the selective uptake of high density lipoprotein-asso-ciated cholesterol ester. J Biol Chem 262:2443–2450PubMedGoogle Scholar
  146. 146.
    Rail SC jr, Weisgraber KH, Innerarity TL, Mahley RW (1982) Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hy-perlipoproteinemic subjects. Proc Natl Acad Sci USA 79:4696–4700Google Scholar
  147. 147.
    Rifici VA, Eder HA (1984) A hepato-cyte receptor for high density lipoproteins specific for Apolipoprotein A-I. J Biol Chem 259:13814–13818PubMedGoogle Scholar
  148. 148.
    Rinninger F, Pittman RC, (1987) Regulation of selective uptake of HDL cholesterol esters by human fibroblasts and Hep G2 cells. Arteriosclerosis 7:543 a (Abstract)Google Scholar
  149. 149.
    Robenek H, Schmitz G (1988) Ca-an-tagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. II. Characterization of intracellular morphologic changes. Arteriosclerosis 8:57–67PubMedGoogle Scholar
  150. 150.
    Russell DW, Yamamoto T, Schneider WJ, Slaughter CJ, Brown MS, Goldstein JL (1983 a) cDNA cloning of the bovine low density lipoprotein receptor: Feedback regulation of a receptor mRNA. Proc Natl Acad Sci USA 80:7501–7505PubMedGoogle Scholar
  151. 151.
    Sasaki J, Okamura T, Cottam GL (1983) Measurement of receptor-independent metabolism of low-density lipoprotein. An application of glycosylated low-density lipoprotein. Eur J Biochem 131:535–538PubMedGoogle Scholar
  152. 152.
    Schmitz G, Assmann G, Robenek H, Brennhausen B (1985) Tangier Disease: A disorder of intracellular membrane traffic. Proc Natl Acad Sci USA 82:6305–6309PubMedGoogle Scholar
  153. 153.
    Schmitz G, Niemann R, Brennhausen B, Krause R, Assmann G (1985) Regulation if high density lipoprotein receptors in cultured macrophages: Role of acyl-CoA: cholesterol acyltransferase EMBO J 4:2773–2779PubMedGoogle Scholar
  154. 154.
    Schmitz G, Robenek H, Beuck M, Krause R, Schurek A, Nieman R (1988) Ca-antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. I. Characterization of cellular lipid metabolism. Arteriosclerosis 8:46–56PubMedGoogle Scholar
  155. 155.
    Schmitz G, Robenek H, Lohmann V, Assmann G (1985) Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: Biochemical and morphological characterization of cell surface receptor binding, endocyto-sis and resecretion of high density lipoproteins by macrophages. EMBO J 4:613–622PubMedGoogle Scholar
  156. 156.
    Schmitz G, Wulf G, Brüning T, Assmann G (1988) Flow-cytometric determination of high-density-lipoprotein binding sites on human leucocytes. Clin Chem 33:2195–2203Google Scholar
  157. 157.
    Schneider HG, Stange EF (1987) Evidence for the compartmentalisation of cholesterol in cultured intestinal cells. Gastroenterology 92:1624 (abstract)Google Scholar
  158. 158.
    Schneider WJ, Slaughter CJ, Goldstein JL, Anderson RGW, Capra DJ, Brown MS (1983) Use of antipeptide antibodies to demonstrate external orientation of the NH2 terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts. J Cell Biol 97:1635–1640PubMedGoogle Scholar
  159. 159.
    Segrest JP, Jackson RL, Morrisett JD, Gotto AM jr (1974) A molecular theory of lipid-protein interactions in the plasma lipoproteins. FEBS Lett 38:247–253PubMedGoogle Scholar
  160. 160.
    Shepherd J, Bicker S, Lorimer AR, Packard CJ (1979) Receptor-mediated LDL catabolism in man. J Lipid Res 20:999–1006PubMedGoogle Scholar
  161. 161.
    Sherrill BC, Dietschy JM (1978) Characterization of the sinusoidal transport process responsible for uptake of chylomicrons by the liver. J Biol Chem 253:1859–1867PubMedGoogle Scholar
  162. 162.
    Sherrill BC, Innerarity TL, Mahley RW (1980) Rapid hepatic clearance of canine lipoproteins containing only the E apoprotein by a high affinity receptor. J Biol Chem 255:1804–1807PubMedGoogle Scholar
  163. 163.
    Slater HR, McKinney L, Packard CJ, Shepherd J (1984) Contribution of the receptor pathway to LDL catabolism in humans. Arteriosclerosis 4:604–613PubMedGoogle Scholar
  164. 164.
    Sloop CH, Dory L, Roheim PS (1987) Interstitial fluid lipoproteins. J Lipid Res 28:225–237PubMedGoogle Scholar
  165. 165.
    Slotte JP, Oram JF, Bierman EL (1987) Binding of high density lipoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface. J Biol Chem 262:12094–12907Google Scholar
  166. 166.
    Soutar AK, Garner CW, Baker HN, Sparrow JT, Jackson RL, Gotto AM, Smith LC (1975) Effect of the human plasma apolipoproteins and phosphatidylcholine acyl donor on the activity of lecithin: cholesterol acyltransferase. Biochemistry 14:3057–3064PubMedGoogle Scholar
  167. 167.
    Spady DK, Bilheimer DW, Dietschy JM (1983) Rates of receptor dependent and -independent low density lipoprotein uptake in the hamster. Proc Natl Acad Sci USA 80:3499–3503PubMedGoogle Scholar
  168. 168.
    Stein O, Stein Y (1980) Bovine aortic endothelial cells display macrophage-like properties towards acetylated 125 I-labelled low density lipoprotein. Biochim Biophys Acta 620:631–635PubMedGoogle Scholar
  169. 169.
    Steinmetz A, Kaffarnik H, Utermann G (1985) Activation of phosphatidylcholine-sterol acyltransferase by human apolipoprotein E isoforms. Eur J Biochem 152:747–751Google Scholar
  170. 170.
    Steinmetz A, Utermann G (1985) Activation of lecithin: cholesterol acyltransferase by human apolipoprotein A-IV. J Biol Chem 260:2258–2264PubMedGoogle Scholar
  171. 171.
    Südhof TC, Goldstein JL, Brown MS, Russell DW (1985) The LDL receptor gene: A mosaic of exons shared with different proteins. Science 228:815–822PubMedGoogle Scholar
  172. 172.
    Südhof TC, Russell DW, Brown MS, Goldstein JL (1987) 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. Cell 48:1061–1069PubMedGoogle Scholar
  173. 173.
    Tabas I, Tall AR (1984) Mechanism of the association of HDL3 with endothelial cells, smooth muscle cells and fibroblasts. Evidence against the role of specific ligand and receptor proteins. J Biol Chem 259:13897–13905PubMedGoogle Scholar
  174. 174.
    Tauber JP, Goldminz D, Gospodarowicz D (1981) Up-regulation in vascular endothelial cells of binding sites of high density lipoprotein induced by 25-hydroxycholesterol. Eur J Biochem 119:327–339PubMedGoogle Scholar
  175. 175.
    Thompson GR, Soutar AK, Spengel FA, Jadhav A, Gavigan SJP, Myant NB (1981) Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyreoidism in vivo. Proc Natl Sci USA 78:2591–2595Google Scholar
  176. 176.
    Tolleshaug H, Goldstein JL, Schneider WJ, Brown MS, (1982) Posttransla-tional processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia. Cell 30:715–724PubMedGoogle Scholar
  177. 177.
    Traber MG, Kayden HJ (1980) Low-density lipoprotein receptor activity in human moncyte derived-macrophages and its relation to atheromatous lesions. Proc Natl Acad Sci USA 77:5466–5470PubMedGoogle Scholar
  178. 178.
    Utermann G, Vogelberg KH, Steinmetz A, Schönborn W, Pruin N, Jaeschke M, Hees M, Canzler H (1979) Polymorphism of apolipoprotein E: II) Genetics of hyperlipoproteinemia type III. Clin Genet 14:351–358Google Scholar
  179. 179.
    Van Lenten BJ, Fogelman AM, Hokom M, Benson L, Haberland ME, Edwards PA (1983) Regulation of the uptake and degradation of β-very low density lipoprotein in human monocyte macrophages. J Biol Chem 258:5151–5157PubMedGoogle Scholar
  180. 180.
    van’t Hooft FM, van Tol A (1985) The site of degradation of rat high density lipoprotein apolipoprotein E specifically labeled with O-(4-diazo-3-(1125)iodobenzoyl)sucrose. Biochem J 226:715–721Google Scholar
  181. 181.
    van Tol A, Dallinga-Thie GM, van Gent T, van’t Hooft FM (1986) Specific saturable binding of rat high density lipoproteins to rat kidney membranes. Biochim Biophys Acta 876:340–351PubMedGoogle Scholar
  182. 182.
    Via DP, Dresel HA, Cheng SL, Gotto AM jr (1985) Murine macrophage tumors are a source of a 260000 Dalton acetyl-low density lipoprotein receptor. J Biol Chem 260:7379–7386PubMedGoogle Scholar
  183. 183.
    Via DP, Plant AL, Craig IF, Gotto AM jr (1985) Metabolism of normal and modified low-density lipoproteins by macrophage cell lines of murine and human orign. Biochim Biophys Acta 833:417–428PubMedGoogle Scholar
  184. 184.
    Wang-Iverson P, Ginsberg HN, Pe-teanu LA, Le N-A, Brown WV (1985) Apolipoprotein E-mediated uptake and degradation of normal very-low-density lipoproteins by human monocyte macrophages. A saturable pathway distinct from the low-density lipoprotein receptor. Biochem Biophys Res Commun 126:578–586PubMedGoogle Scholar
  185. 185.
    Weisgraber KH, Innerarity TL, Mahley RW (1982) Abnormal lipoprotein receptor-binding activity of the human apo E apoprotein due to cysteine-argi-nine interchange at a single site. J Biol Chem 257:2518–2521PubMedGoogle Scholar
  186. 186.
    Weisgraber KH, Innerarity TL, Mahley RW (1978) Role of the lysine resiues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts. J Biol Chem 253:9053–9062PubMedGoogle Scholar
  187. 187.
    Yamamoto T, Davis CG, Brown MS, Schneider WJ, Casey ML, Goldstein JL, Russell DW (1984) The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA. Cell 39:27–38PubMedGoogle Scholar
  188. 188.
    Zorich N, Jonas A, Pownall HJ (1985) Activation of lecithin: cholesterol acyl-transferase by human apolipoprotein E in discoidal complexes with lipids. J Biol Chem 260:8831–8837Google Scholar
  189. 189.
    Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW (1981) Familial dysbetalipoproteinemia. Abnormal binding of mutant apolipoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. J Clin Invest 68:1075–1085PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. Steinmetz
    • 1
  • G. Utermann
    • 2
  1. 1.Abteilung Endokrinologie und Stoffwechsel, Zentrum Innere MedizinUniversität MarburgMarburgDeutschland
  2. 2.Institut für medizinische Biologie und GenetikUniversität InnsbruckDeutschland

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