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Der Internist pp 232-238 | Cite as

Milde Hypertonie — eine kritische Analyse der Interventionsstudien

  • H. Holzgreve
Chapter

Zusammenfassung

Sieben Hypertonie-Interventionsstudien werden im Hinblick auf die tödlichen und nicht-tödlichen Organfolgen des Hochdrucks im Zusammenhang mit der Behandlung analysiert, um daraus Schlußfolgerungen für das Vorgehen bei milder Hypertonie abzuleiten. Außerdem werden spezielle Probleme hinsichtlich der milden Hypertonie angesprochen, die durch die Interventionsstudien nicht oder nur unzureichend geklärt sind oder durch deren Endresultate aufgeworfen werden.

Schlüsselwörter

Milde Hypertonie Therapiestudien Langzeitprognose 

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Literatur

  1. 1.
    Amery A, Birkenhäger W, Brixko P, Bulpitt C, Clement D, Deruyttere M, De Schaepdryver A, Dollery C, Fagard R, Forette F, Forte J, Hamdy R, Henry JF, Loossens JV, Leonetti G, Lund-Johan-sen P, O’Malley K, Petrie J, Strasser T, Tuomilehto J, Williams B (1985) Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trial. Lancet 1:1349–1354PubMedCrossRefGoogle Scholar
  2. 2.
    Cruickshank JM, Thorp JM, Zacharias F J (1987) Benefits and potential harm of lowering high blood pressure. Lancet 1:581–584PubMedCrossRefGoogle Scholar
  3. 3.
    Grimm RH, Cohen JD, McFate Smith W, Falvo-Gerard L, Neaton JD, and the Multiple Risk Factor Intervention Trial Research Group (1985) Hypertension management in the multiple risk factor intervention trial (MRFIT). Six-year intervention results for men in special intervention and usual care groups. Arch Intern Med 145:1191–1199PubMedCrossRefGoogle Scholar
  4. 4.
    Helgeland A (1980) Treatment of mild hypertension. A five year controlled drug trial. The Oslo Study. Am J Med 69:725–732PubMedCrossRefGoogle Scholar
  5. 5.
    Hypertension Detection and Follow-up Program Cooperative Group (1979) Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. JAMA 242:2562–2571CrossRefGoogle Scholar
  6. 6.
    Hypertension Detection and Follow-up Program Cooperative Group (1979) Five-year findings of the hypertension detection and follow-up program. II. Mortality by race-sex and age. JAMA 242:2572–2577CrossRefGoogle Scholar
  7. 7.
    Hypertension Detection and Follow-up Program Cooperative Group (1982) Five-year findings of the hypertension detection and follow-up program. III. Reduction in stroke incidence among persons with high blood pressure. JAMA 247:633–638CrossRefGoogle Scholar
  8. 8.
    Hypertension Detection and Follow-up Program Cooperative Group (1982) The effect of treatment on mortality in “mild” hypertension. New Engl J Med 307:976–980CrossRefGoogle Scholar
  9. 9.
    Hypertension Detection and Follow-up Program Cooperative Research Group (1984) The effect of antihypertensive drug treatment on mortality in the presence of resting electrocardiographic abnormalities at baseline: the HDFP experience. Circulation 79:996–1003Google Scholar
  10. 10.
    Hypertension Detection and Follow-up Program Cooperative Group (1984) Effect of stepped care treatment on the incidence of myocardial infarction and angina pectoris. 5-year findings. Hypertension 6 [Suppl 1]: 198–206Google Scholar
  11. 11.
    Hypertension Detection and Follow-up Program Cooperative Group (1985) Five-year findings of the hypertension detection and follow-up program. Prevention and reversal of left ventricular hypertrophy with antihypertensive drug therapy. Hypertension 7:105–112CrossRefGoogle Scholar
  12. 12.
    IPPPSH Collaborative Group (1985) Cardiovascular risk and risk factors in a randomized trial of treatment based on the beta-blocker Oxprenolol: the International prospective primary prevention study in hypertension (IPPPSH). J Hypertens 3:379–392CrossRefGoogle Scholar
  13. 13.
    McFate Smith W (1977) Treatment of mild hypertension. Results of a ten-year intervention trial. U.S. Public Health Service Hospitals Cooperative Study Group. Circ Res 40 [Suppl 1]: 98–105CrossRefGoogle Scholar
  14. 14.
    Management Committee (1980) The australian therapeutic trial in mild hypertension. Lancet 1:1261–1267Google Scholar
  15. 15.
    Management Committee of the Australian Therapeutic Trial in Mild Hypertension (1982) Untreated mild hypertension. Lancet 1:185–191Google Scholar
  16. 16.
    Medical Research Council Working Party (1985) MRC trial of treatment of mild hypertension: principal results. Br Med J 291:97–104CrossRefGoogle Scholar
  17. 17.
    Multiple Risk-Factor Intervention Trial Research Group (1982) Multiple risk factor intervention trial. Risk factor changes and mortality results. JAMA 248:1465–1477CrossRefGoogle Scholar
  18. 18.
    Samuelsson O, Wilhelmsen L, Andersson OK, Pennert K, Berglund G (1987) Cardiovascular morbidity in relation to change in blood pressure and serum cholesterol levels in treated hypertension. Results from the primary prevention trial in Göteborg, Sweden. JAMA 258:1768–1776PubMedCrossRefGoogle Scholar
  19. 19.
    Veterans Administration Cooperative Study Group on Antihypertensive Agents (1970) Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mmHg. JAMA 213:1143–1152CrossRefGoogle Scholar
  20. 20.
    Veterans Administration Cooperative Study Group on Antihypertensive Agents (1972) Effects of treatment on morbidity in hypertension. III. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects. Circulation 45:991–1004CrossRefGoogle Scholar
  21. 21.
    Wilhelmsen L, Berglund G, Elmfeldt D, Fitzsimons T, Holzgreve H, Hosie J, Hörnkvist P-E, Pennert K, Tuomilehto H, Wedel, H (1987) Beta-blockers versus diuretics in hypertensive men: main results from the HAPPHY trial. J Hypertens 5:561–572PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H. Holzgreve
    • 1
  1. 1.Medizinische PoliklinikUniversität MünchenMünchen 2Deutschland

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