Advertisement

Der Internist pp 828-832 | Cite as

40jähriger Patient mit progredienter Leistungsminderung und Cor pulmonale

  • J. Behr
  • G. König
  • T. Reinertshofer
  • R. Lund
  • W. von Scheidt
  • G. Fruhmann
Chapter

Zusammenfassung

Der 40jährige Patient stellt sich wegen zunehmender Leistungsminderung, Abgeschlagenheit, starker Müdigkeit, Nachtschweiß und morgendlicher Kopfschmerzen vor. Vorausgegangen war ein fieberhafter, bronchopulmonaler Infekt, der unter antibiotischer Therapie rasch abklang. Von der Ehefrau wurde berichtet, daß er mehrmals plötzlich in sich zusammengesunken war und auch durch Rütteln nur langsam wieder zu sich kam. Die allgemeine Vorgeschichte und die Familienanamnese wiesen keine Besonderheiten auf.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Adickes ED, Buehler BA, Sanger WG (1986) Familial lethal sleep apnea. Hum Genet 73:39–43PubMedCrossRefGoogle Scholar
  2. 2.
    Alexander JK, West JR, Wood JA, Richards DW (1955) Analysis of the respiratory response to carbon dioxide inhalation in varying clinical states of hyper-capnia, anoxia, and acid-base derangement. J Clin Invet 34:511–532CrossRefGoogle Scholar
  3. 3.
    Barlow PB, Bartlett D, Hauri P, Hellekson C, Nattie EE, Remmers JE, Schmidt-Nowara WW (1980) Idiopathic hypoventilation syndrome: Importance of preventing nocturnal hypoxemia and hypercapnia. Am Rev Respir Dis 121:141–145PubMedGoogle Scholar
  4. 4.
    Berman TM, Bartlett M, Westgate HD, Steiner KR, Kronenberg RS (1981) Attenuated response to CO2 and hypoxia in parents of threatened sudden infant death syndrome infants. Chest 79:536–539PubMedCrossRefGoogle Scholar
  5. 5.
    Berthan-Jones M, Sullivan CE (1987) Time course of change in ventilatory response to CO2 with long-term CPAP therapy for obstructive sleep apnea. Am Rev Respir Dis 135:144–147Google Scholar
  6. 6.
    Bubis MJ, Anthonisen NR (1978) Primary alveolar hypoventilation treated by nocturnal administration of O2. Am Rev Respir Dis 118:947–953PubMedGoogle Scholar
  7. 7.
    Coleman M, Boros SJ, Huseby TL, Brennom WS (1979) Congenital central hypoventilation syndrome. Am Rev Respir Dis 119:901–903Google Scholar
  8. 8.
    Chaudhary BA, Elgwindi AS, King DW (1982) Obstructive sleep apnea after lateral medullary syndrome. South Med J 75:65–67PubMedCrossRefGoogle Scholar
  9. 9.
    Deonna T, Arczynska W, Torrado A (1974) Congenital failure of automatic ventilation (Ondine’s curse). J Pediatr 84:710–714PubMedCrossRefGoogle Scholar
  10. 10.
    Ellis ER, Bye PTP, Bruderer JW, Sullivan CE (1987) Treatment of respiratory failure during sleep in patients with neuromuscular disease. Am Rev Respir Dis 135:148–152PubMedGoogle Scholar
  11. 11.
    Ellis ER, McCauley VB, Mellis C, Sullivan CE (1987) Treatment of alveolar hyperventilation in a six-year-old girl with intermittent positive pressure ventilation through a nose mask. Am Rev Respir Dis 136:188–191PubMedCrossRefGoogle Scholar
  12. 12.
    Fruhman G (1972) Hypersomnia with primary hypoventilation syndrome and following cor pulmonale. Bull Physiol Pathol Respir 8:1173–1179Google Scholar
  13. 13.
    Fuchs J, Kummer F (1980) Familiäre Störung der zentralen Atemregulation. Prax Pneumol 34:615–619Google Scholar
  14. 14.
    Garay SM, Rapoport D, Sorkin B, Epstein H, Feinberg I, Goldring RM (1981) Regulation of ventilation in the obstructive sleep apnea syndrome. Am Rev Respir Dis 124:451–457PubMedGoogle Scholar
  15. 15.
    Glenn WWL, Phelps ML, Elefteriades JA, Dentz B, Hogan JF (1986) Twenty years of experience in phrenic nerve stimulation to pace the diaphragm. Pace 9:780–784PubMedCrossRefGoogle Scholar
  16. 16.
    Hall JB (1986) The cardiopulmonary failure of sleep-disordered breathing. JAMA 255:930–933PubMedCrossRefGoogle Scholar
  17. 17.
    Hirshman CA, McCullough RE, Weil JV (1975) Normal values for hypoxic and hypercapnic ventilatory drives in man. J Appl Physiol 38:1095–1098PubMedGoogle Scholar
  18. 18.
    Hyland RH, Jones NL, Powles ACP, Lenkie SCM, Vanderlinden RG, Epstein SW (1978) Primary alveolar hypoventilation treated with nocturnal electro-phrenic respiration. Am Rev Respir Dis 117:165–172PubMedGoogle Scholar
  19. 19.
    König G, Albrecht J, Attenberger E, Fruhmann G (1982) Respiratorische Insuffizienz infolge zentraler Atemstörung. MMW 124:903–906Google Scholar
  20. 20.
    König G, Röder W (1981) Intermittierende Zyanose nach Meningoencephalitis tuberculosa. Internist 22:96–98PubMedGoogle Scholar
  21. 21.
    Kummer F (1981) Die zentrale Atemregulationsstörung. Prax Pneumol 35:203–208Google Scholar
  22. 22.
    Kurtz D, Krieger J (1978) Analysis of apnea in sleep apnea. In: Guilleminault C, Dement WC (Hrsg) Sleep apnea syndromes. Liss, New York, pp 145–159Google Scholar
  23. 23.
    Man GCW, Jones RL, McDonald GF, King EG (1979) Primary alveolar hypoventilation managed by negative-pressure ventilators. Chest 76:219–221PubMedCrossRefGoogle Scholar
  24. 24.
    Mellins RB, Balfour HH, Turino GM, Winters RW (1970) Failure of automatic control of ventilation (Ondine’s curse). Medicine 49:487–504PubMedCrossRefGoogle Scholar
  25. 25.
    Nattie EE, Bartlett D, Rozyck AA (1975) Central alveolar hypoventilation in a child: An evaluation using a whole body Plethysmograph. Am Rev Respir Dis 112:259–266PubMedGoogle Scholar
  26. 26.
    Naughton J, Block B, Welch M (1971) Central alveolar hypoventilation. Am Rev Respir Dis 103:557–565PubMedGoogle Scholar
  27. 27.
    Paine CJ, Hargrove MD (1973) Primary alveolar hypoventilation in a thin young woman. Chest 63:854–855PubMedCrossRefGoogle Scholar
  28. 28.
    Phillipson EA (1978) Control of breathing during sleep. Am Rev Respir Dis 118:909–939PubMedGoogle Scholar
  29. 29.
    Podszus T, Bauer W, Mayer J, Penzel T, Peter JH, v. Wichert P (1986) Sleep apnea and pulmonary hypertension. Klin Wochenschr 64:131–134PubMedCrossRefGoogle Scholar
  30. 30.
    Ratto O, Briscoe WA, Morton JW, Comroe JH (1955) Anoxemia secondary to polycythemia and polycythemia secondary to anoxemia. Am J Med 19:958–965PubMedCrossRefGoogle Scholar
  31. 31.
    Russi E (1987) Diagnose und Pathophysiologie der Schlaf-Apnoe-Syndrome. Dtsch Med Wochenschr 112:1543–1544PubMedCrossRefGoogle Scholar
  32. 32.
    Seriff NS (1965) Alveolar Hypoventilation with normal lungs : The syndrome of primary or central alveolar hypoventilation. Ann NY Acad Sci 121:691–705PubMedCrossRefGoogle Scholar
  33. 33.
    Severinghaus JW, Mitchell RA (1962) Ondinés curse — failure of respiratory center automaticity while awake. Clin Res 10:122 (Abstract)Google Scholar
  34. 34.
    Shannon DC, Kelly DH, O’Connell K (1977) Abnormal regulation of ventilation in infants at risk for sudden-infant-death syndrome. N Engl J Med 297:747–750PubMedCrossRefGoogle Scholar
  35. 35.
    Shepard JW (1985) Gas exchange and hemodynamics during sleep. Med Clin North Am 69:1243–1264PubMedGoogle Scholar
  36. 36.
    Solliday NH, Gaensler EA, Schwaber JR, Parker TF (1974) Impaired central chemoreceptor function and chronic hypoventilation many years following poliomyelitis. Respiration 31:177–192PubMedCrossRefGoogle Scholar
  37. 37.
    Strohl KP, Cherniack NS, Gothe B (1986) Physiologic basis of therapy for sleep apnea. Am Rev Repir Dis 134:791–802Google Scholar
  38. 38.
    Tobin MJ, Cohn MA, Sachner MA (1983) Breathing abnormalities during sleep. Arch Intern Med 143:1221–1228PubMedCrossRefGoogle Scholar
  39. 39.
    White DP (1985) Central sleep apnea. Med Clin North Am 69:1205–1219PubMedGoogle Scholar
  40. 40.
    White DP, Zwillich CW, Pickett CK, Douglas NJ, Findley LJ, Weil JV (1982) Central sleep apnea. Improvement with acetazolamide therapy. Arch Intern Med 142:1816–1819PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. Behr
    • 1
  • G. König
    • 2
  • T. Reinertshofer
    • 3
  • R. Lund
    • 3
  • W. von Scheidt
    • 2
  • G. Fruhmann
    • 2
  1. 1.Pneumologische Abteilung, Medizinische Klinik IKlinikum GroßhadernMünchen 70Deutschland
  2. 2.Pneumologische Abteilung , Medizinische Klinik IKlinikum GroßhadernDeutschland
  3. 3.Psychiatrische KlinikUniversität MünchenDeutschland

Personalised recommendations