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Zur Seroprävalenz von Herpes-simplex-Virus Typ 2 (HSV-2) in Thüringen

  • Peter Wutzier
  • I. Färber
  • U. Eichhorn
  • B. Helbig
  • A. Sauerbrei
  • A. Brandstädt
Chapter

Zusammenfassung

Herpes-simplex-Viren (HSV-1, HSV-2) sind die häufigste infektiöse Ursache von genitalen Ulzerationen.Trotz einer Zunahme primärer genitaler HSV-1-Infektionen ist HSV-2 der dominante Virustyp bei rezidivierenden Erkrankungen. Rückschlüsse auf die Häufigkeit des genitalen Herpes können daher aus der Prävalenz von HSV-2-spezifischen Antikörpern in der Bevölkerung gezogen werden. Diese Studie wurde an einem Panel von Serumproben durchgeführt, das 1996 und 1997 anonym von 1979 Blutspendern und 3079 Klinikpatienten gesammelt worden war. Die Patienten hatten keine bekannten Risikofaktoren bezüglich HSV-Infektionen wie sexuell übertragbare Krankheiten, andere Infektionskrankheiten oder eine immunsuppressive Therapie. Die Serumproben wurden mit typenspezifischen ELISA-Testen, die auf den gereinigten nativen Glykoproteinen gG1 bzw.gG2 basieren sowie einem Immunoblot mit typenspezifischen rekombinanten Glykoproteinen untersucht. Die Abklärung fraglicher Reaktionsausfälle erfolgte mit einem In-Haus-Westernblot.

Die HSV-1-Seroprävalenz korrelierte eng mit dem Alter und war bei Personen ≥40 Jahre mit ca. 90% am höchsten. Im Gesamtkollektiv hatten 12,8% (95% CI 11,9-13,8%) der Probanden Antikörper gegen HSV-2. Die HSV-2-Seroprävalenz war bei Frauen (15%; 95% CI 13,7-16,4%) signifikant höher als bei Männern (10,5%; 95% CI 9,3-11,8%), was einem altersadjustierten Odds Ratio für Patienten von 1,5 (95%-CI 1,19-1,90) und für Blutspender von 1,67 (95%-CI 1,29-2,15) entspricht.

Schlüsselwörter

Herpes simplex-Virus Typ 1 Herpes simplex-Virus Typ 2 Seroprävalenz Herpes genitalis Epidemiologie Typenspezifische Antikörper 

Seroprevalence of Herpes simplex virus type 2 infections in blood donors and clinic patients in Thuringia, Germany

Summary

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are the most frequent infections cause of genital ulcerations. Although genital infections by HSV-1 are increasing HSV-2 is dominant in recurrent infections. This study was conducted on a panel of sera collected anonymously in 1996 and 1997 from blood donors (1979 samples) and hospital patients (3079 samples) without risk factors for herpesvirus infections such as STD, other infectious diseases and immunosuppression. Serum samples were tested with ELISAs using monoclonal antibody-selected native gG1 and gG2 as antigens and an immunoblot using type-specific recombinant glycoproteins. Equivocal results were confirmed with an in-house Western blot. HSV-1 prevalence correlated strongly with age and was highest (about 90%) among subjects 40 years of age or older. In the total sample, the HSV-2 seroprevalence was 12.8% (95% CI 11.9-13.8%). The HSV-2 seroprevalence was significantly higher among women (15%; 95% CI 13.7-16.4%) than among men (10.5%; 95% CI 9.3-11.8%), yielding a female: male age adjusted odds ratio of 1.5 (95%-CI 1.19-1.90%) for hospital patients and of 1.67 (95%-CI 1.29–2.15%) for blood donors.

Key words

Herpes simplex virus type 1 Herpes simplex virus type 2 Seroprevalence Herpes genitalis Epidemiology Typespecific antibodies 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Peter Wutzier
    • 2
  • I. Färber
    • 1
  • U. Eichhorn
    • 1
  • B. Helbig
    • 1
  • A. Sauerbrei
    • 1
  • A. Brandstädt
    • 2
  1. 1.Institut für Medizinische Statistik, Informatik und DokumentationFriedrich-Schiller-UniversitätJenaDeutschland
  2. 2.Institut für Antivirale ChemotherapieFriedrich-Schiller-Universität JenaErfurtDeutschland

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