Mouse Hepatitis Virus Infection, Intestine, Mouse

  • Stephen W. Barthold
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY, volume 3)


Enterotropic mouse hepatitis virus (MHV) infection is usually subclinical, with no gross lesions. Neonatal mice suffer high mortality when the virus is first introduced to a naive breeding population. They become dehydrated, with soiling of the perineum with yellow, pasty feces. Their stomachs are usually empty, and intestines are thin-walled, flaccid, and contain watery yellow digesta and gas. Juvenile mice are less severely affected, but are often runted with pot bellies and oily-appearing hair. Careful examination of weaning-age or adult mice may reveal dark, sticky feces and opaque, thickened segments of bowel. Livers, if affected, have few to many small, pale or hemorrhagic foci (see “Mouse Hepatic Virus Infection, Liver, Mouse,” this volume; Barthold 1986; Barthold and Smith 1984; Barthold et al. 1982,1993; Broderson et al. 1976; Hierholzer et al. 1979; Ishida and Fujiwara 1979; Ishida et al. 1978; Kraft 1962, 1966). Athymic nude mice infected with enterotropic MHV may have segmental thickening of the cecum and ascending colon, with enlargement of mesenteric lymph nodes (Barthold et al. 1985; Ward et al. 1977).


Enterotropic Coronavirus infection mouse lethal intestinal virus of infant mice (LIVIM) 


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© Springer-Verlag Berlin Heidelberg 1997

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  • Stephen W. Barthold

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