Cytomegalovirus Infection, Salivary Glands, Mouse, Rat, and Hamster

  • Stephen W. Barthold
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY, volume 3)


Under most circumstances there are no grossly visible lesions. During acute, generalized infections in mice, the liver may be enlarged and pale with hemorrhagic foci. Intestinal serosa can be irregularly reddened and mucosa congested (McCordock and Smith 1936). Mineralization of skeletal muscle and brown fat (Lussier 1975) and blood-tinged ascitic fluid (Olding et al. 1976) have also been observed. Mice infected as neonates are runted with thymic and splenic involution (Schwartz et al. 1975).


Salivary gland virus infection cytomegalic inclusion disease 


  1. Bentvelzen P, Hilgers J (1980) Murine mammary tumor virus. In: Klein G (ed) Viral oncology. Raven, New York, pp 311–355Google Scholar
  2. Brautigam AR, Dutko EJ, Olding LB, Oldstone MB (1979) Pathogenesis of murine cytomegalovirus infection: the macrophage as a permissive cell for cytomegalovirus infection, replication and latency. J Gen Virol 44:349–359PubMedCrossRefGoogle Scholar
  3. Brodsky I, Rowe WP (1958) Chronic subclinical infection with mouse salivary gland virus. Proc Soc Exp Biol Med 99:654–655PubMedCrossRefGoogle Scholar
  4. Brody AR, Craighead JE (1974) Pathogenesis of pulmonary cytomegalovirus infection in immunosuppressed mice. J Infect Dis 129:677–689PubMedCrossRefGoogle Scholar
  5. Bruggeman CA, Meijer H, Bosman F, van Boven CPA (1985) Biology of rat cytomegalovirus infection. Intervirology 24:1–9PubMedCrossRefGoogle Scholar
  6. Chantier JK, Misra V, Hudson JB (1979) Vertical transmission of murine cytomegalovirus. J Gen Virol 42:621–625CrossRefGoogle Scholar
  7. Cheung KS, Huang ES, Lang DJ (1980) Murine cytomegalovirus: detection of latent infection by nucleic acid hybridization technique. Infect Immun 27:851–854PubMedGoogle Scholar
  8. Cross SS, Parker JC, Rowe WP, Robbins ML (1979) Biology of mouse thymic virus, a herpesvirus of mice, and the antigenic relationship to mouse cytomegalovirus. Infect Immun 26:1186–1195PubMedGoogle Scholar
  9. Gardner MB, Officer JE, Parker J, Estes JD, Rongey RW (1974) Induction of disseminated virulent cytomegalovirus infection by immunosuppression of naturally chronically infected wild mice. Infect Immun 10:966–969PubMedGoogle Scholar
  10. Hamilton JR, Overall JC Jr (1978) Synergistic infection with murine cytomegalovirus and Pseudomonas aeruginosa in mice. J Infect Dis 137:775–782PubMedCrossRefGoogle Scholar
  11. Henson D, Strano AJ (1972) Mouse cytomegalovirus. Necrosis of infected and morphologically normal submaxillary gland acinar cells during termination of chronic infection. Am J Pathol 68:183–202PubMedGoogle Scholar
  12. Ho M (1980) Role of specific cytotoxic lymphocytes in cellular immunity against murine cytomegalovirus. Infect Immun 27:767–776PubMedGoogle Scholar
  13. Hudson JB (1979) The murine cytomegalovirus as a model for the study of viral pathogenesis and persistent infections. Arch Virol 62:1–29PubMedCrossRefGoogle Scholar
  14. Jordan MC (1978) Interstitial pneumonia and subclinical infection after intranasal inoculation of murine cytomegalovirus. Infect Immun 21:275–280PubMedGoogle Scholar
  15. Lussier G (1975) Murine cytomegalovirus (MCMV). Adv Vet Sci Comp Med 9:223–247Google Scholar
  16. Lyon HW, Christian JJ, Miller CW (1959) Cytomegalic inclusion disease of lacrimal glands in male laboratory rats. Proc Soc Exp Biol Med 10:164–166Google Scholar
  17. Mannini A, Medearis DN Jr (1961) Mouse salivary gland virus infections. Am J Hyg 73:329–343PubMedGoogle Scholar
  18. McCordock HA, Smith MG (1936) The visceral lesions produced in mice by the salivary gland virus of mice. J Exp Med 63:303–310PubMedCrossRefGoogle Scholar
  19. Medearis DN Jr (1964) Mouse cytomegalovirus infection. III. Attempts to produce intrauterine infections. Am J Hyg 80:113–120PubMedGoogle Scholar
  20. Mims CA, Gould J (1979) Infection of salivary glands, kidneys, adrenals, ovaries and epithelia by murine cytomegalovirus. J Med Microbial 12:113–122CrossRefGoogle Scholar
  21. Montplaisir S (1979) Latency and activation of cytomegalovirus in man and in mice. Can J Microbiol 25:261–266PubMedCrossRefGoogle Scholar
  22. Olding LB, Kingsbury DT, Oldstone MB (1976) Pathogenesis of cytomegalovirus infection. Distribution of viral products, immune complexes and autoimmunity during latent murine infection. J Gen Virol 33:267–280PubMedCrossRefGoogle Scholar
  23. Osborn JE, Shahidi NT (1973) Thrombocytopenia in murine cytomegalovirus infection. J Lab Clin Med 81:53–63PubMedGoogle Scholar
  24. Priscott PK, Tyrrell DA (1982) The isolation and partial characterization of a cytomegalovirus from the brown rat Rattus norvegicus. Arch Virol 73:145–160PubMedCrossRefGoogle Scholar
  25. Ruebner BH, Miyai K, Slusser RJ, Wedemeyer P, Medearis DN Jr (1964) Mouse cytomegalovirus infection. An electron microscopic study of hepatic parenchymal cells. Am J Pathol 44:799–821PubMedGoogle Scholar
  26. Ruebner BH, Hirano T, Slusser R, Osborn J, Medearis DN Jr (1966) Cytomegalovirus infection. Viral ultrastructure with particular reference to the relationship of lysosomes to cytoplasmic inclusions. Am J Pathol 48:971–989PubMedGoogle Scholar
  27. Schwartz JN, Daniels CA, Klintworth GK (1975) Lymphoid cell necrosis, thymic atrophy, and growth retardation in newborn mice inoculated with murine cytomegalovirus. Am J Pathol 79:509–522PubMedGoogle Scholar
  28. Ward JM, Lock A, Collins MJ, Gonda MA, Reynolds CW (1984) Papovaviral sialoadenitis in athymic nude rats. Lab Anim 18:84–89PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Stephen W. Barthold

There are no affiliations available

Personalised recommendations