Rationale for Surfactant Therapy in Pneumonia

  • A. van’t Veen
  • D. Gommers
  • B. Lachmann
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1997)


Pneumonia remains an important cause of morbidity and mortality, despite advances in antimicrobial therapy. Pneumonia causes injury to the terminal alveolo-capillary unit, which is followed by increased alveolar permeability, pulmonary edema and hemorrhage, and may lead to respiratory failure. It has been demonstrated that the pulmonary surfactant system becomes impaired in pneumonia, causing decreased compliance, atelectasis, pulmonary edema, ventilation-perfusion mismatch, intrapulmonary shunting, and an impaired arterial oxygenation [1–3].


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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. van’t Veen
  • D. Gommers
  • B. Lachmann

There are no affiliations available

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