Markers of Central Nervous System Glia and Neurons In Vivo During Normal and Pathological Conditions

  • J. M. Redwine
  • C. F. Evans
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 265)


Cell markers are valuable tools for examining the function of cells in normal conditions as well as during disease and repair processes. In fact, our understanding of the cell types that make up the central nervous system (CNS) is very much shaped by the markers available to identify them. CNS cell types were originally identified by morphology. The discovery of various proteins specific to certain cells led to the production of cell-type-specific antibodies that have been used to identify cells in situ. An ideal marker is specific to a given cell type in normal conditions and/or during conditions involving injury or disease. As simple as these criteria sound, they are not easy to fulfill. Markers can be expressed on more that one cell type. Astrocytes and olfactory-tract-ensheathing glia both express glial fibrillary acidic protein (GFAP), even though they have clear phe-notypic, anatomical, and functional differences (Ramon-Cueto and Valverde 1995). Also, a marker that is specific for a given cell type in normal conditions can be induced or up-regulated on other cell types during conditions such as inflammation, disease, or injury. Therefore cell type markers alone do not always conclusively identify a cell type.


Myelin Sheath Adult Central Nervous System Central Nervous System Inflammation Oligodendrocyte Progenitor Mature Oligodendrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • J. M. Redwine
    • 1
  • C. F. Evans
    • 1
  1. 1.Dept. of NeuropharmacologyThe Scripps Research InstituteLa JollaUSA

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