Advertisement

Stoffwechsel von Glucose und Glycogen

  • G. Löffler
Chapter
Part of the Springer-Lehrbuch book series (SLB)

Zusammenfassung

Glucose ist ein Schlüsselmolekül für alle höheren Lebewesen einschließlich des Menschen. Bei gesunder Ernährung wird mehr als 50% des Energiebedarfs durch den Abbau von Glucose gedeckt, Glucose kann in Form von Glycogen in allen tierischen Zellen gespeichert werden und dient auf diese Weise als Energiespeicher, um den Kohlenhydratbedarf des Organismus auch bei längerem Hungern zu decken. Der Abbau und Stoffwechsel von Glucose liefert darüber hinaus Bausteine für die Biosynthese einer großen Zahl von Verbindungen. In Anbetracht der Bedeutung des Glucosemoleküls ist es klar, dass es auch Möglichkeiten der Glucosesynthese geben muss. Substrate hierfür sind glucogene Aminosäuren, Lactat und Glycerin.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

Original- und Übersichtsarbeiten

  1. Aggen JB, Nairn AC, Chamerlin R (2000) Regulation of protein phosphatase-1. Chem Biol 7: R13 - R23PubMedCrossRefGoogle Scholar
  2. Aiston S, Trinh KY, Lange AJ, Newgard CB,Agius L (1999) Glucose-6-phosphatase overexpression lowers glucose-6-phosphate and inhibits glykogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. J Biol Chem 274: 24 559–24 566Google Scholar
  3. Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP (1998) Ages and their interaction with Age-receptors in vascular disease and diabetes mellitus I. The Age concept. Cardiovascular Research 37: 586–600Google Scholar
  4. Bollen M, Keppens S, Stalmans W (1998) Specific features of glycogen metabolism in the liver. Biochem J 336: 19–31PubMedGoogle Scholar
  5. Brady MJ, Pessin JE, Saltiel AR (1999) Spatial Compartmentalization in the regulation of glucose metabolism by insulin. Tem 10: 408–413PubMedGoogle Scholar
  6. Cardenas ML, Cornish-Bowden A, Ureta T (1998) Evolution and regulatory role of the hexokinases. Biochim Biophys Acta 1401: 242–264PubMedCrossRefGoogle Scholar
  7. Cohen P (1999) The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction. Phil Trans R Soc Lond B 354: 485–495Google Scholar
  8. Czech MP, Corvera S (1999) Signaling mechanisms that regulate glucose transport. J Biol Chem. 274: 1865–1868PubMedCrossRefGoogle Scholar
  9. Ezaki 0 (1997) Regulatory elements in the insulin-responsive glucose transporter (Glut4) gene. Biochem Biophys Res Comm 241: 1–6PubMedCrossRefGoogle Scholar
  10. Iglesiandela, Mukhtar M, Seoane J, Guinovart JJ (2000) The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. J Biol Chem 275: 10 597–10 603Google Scholar
  11. Jeffrey EP, Thurmond DC, Elmendorf JS, Kenneth JC, Okada S (1999) Molecular basis of insulin-stimulated Glut4 vesicle trafficking. J Biol Chem 274: 2593–2596CrossRefGoogle Scholar
  12. Kletzien RF, Harris Pkw, Foellmi LA (1994) Glucose-6-phosphate dehydrogenase: a „housekeeping“ enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress. Faseb J 8: 174–181PubMedGoogle Scholar
  13. Lisinski I, SchÜRmann A, Joosr HG, Cushman SW, AL-Hasani H (2001) Targeting of Glut6 (formerly Glut9) and Glut8 in rat adipose cells. Biochem J 358: 517–522PubMedCrossRefGoogle Scholar
  14. Mayr B, Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor Creb. Nature Rev Mol Cell Biol 2: 599–609CrossRefGoogle Scholar
  15. Mcvie-Wylie AJ, Lamson DR, Chen YT (2001) Molecular cloning of a novel member of the Glut family of transporters, Slc2A10 (Glut10), localized on chromosome 20 g13.1: A candidate gene for Niddm susceptibility. Genomics 72: 113–117Google Scholar
  16. Omata W, Shibata H, LI L, Takata K, Kojima I (2000) Biochem J 346: 321–328PubMedCrossRefGoogle Scholar
  17. Pilkis SJ (1995) 6-phosphofructo-2-kinase/fructose2,6-bisphosphatase: a metabolic signaling enzyme. Annu Rev Biochem 64: 799–853Google Scholar
  18. Schmidt AM, Yan SD, Yan SF, Stern DM (2000) The biology of the receptor for advanced glycation end products and ist ligands. Biochim Biophys Acta 1498: 99–111PubMedCrossRefGoogle Scholar
  19. Werve G Van DE, Lange A, Newgard C, MÉChin MC, Yazhou Li, Berteloot A (2000) New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. Eur J Biochem 267: 1533–1549PubMedCrossRefGoogle Scholar
  20. Zuniga F, Shi G, Haller J, Rubashkin A, Flynn D, IsErovich P, Fischsarg J (2001) A three-dimensional model of the human facilitative glucose transporter Glut1. J Biol Chem 276: 44970–44975PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • G. Löffler

There are no affiliations available

Personalised recommendations