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Verhandlungen pp 1321-1325 | Cite as

Optical and electron microscopical studies of mesenchymal tumours

  • Satyavati M. Sirsat
Chapter

Abstract

The importance of the role played by connective tissue in normal and abnormal cellular phenomena has been aptly described by Robb-Smith (10), who calls it the biological moderator of cellular energy. It is surprising therefore that so few reports have been published on the fine structure of collagen isolated from neoplasms, specially those of mesenchymal origin. The references to this subject available in literature (1,2,6,7) are not agreed over the observations. This systematic study of human and animal mesenchymal tumours was carried out from two aspects: 1. observation of the fine structure of the collagen fibril and 2. elucidation of the type of alteration produced in the extracellular connective tissue, during an overall transformation of the cellular elements of the mesenchyme. The investigation was carried out at two levels. The biopsy tissue was studied optically, using differential staining techniques for connective tissue. Isolated collagen from the same biopsy was observed in the electron microscope to assess the fibrillar response to tissue alteration at the submicroscopic level.

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References

  1. 1.
    Banfield, W. G.: Proc. Soc. exp. Biol. (N. Y.) 81, 658 (1952).Google Scholar
  2. 2.
    Gale, J. C.: Amer. J. Path. 27, 455 (1951).Google Scholar
  3. 3.
    Gillman, T., J. Penn, D. Bronks and M. Roux: Nature (Lond.) 174, 789 (1954).ADSGoogle Scholar
  4. 4.
    A. M. A. Arch. Path. 59, 733 (1955).Google Scholar
  5. 5.
    Brit. J. Cancer 9, 272 (1955).Google Scholar
  6. 6.
    Kajikawa, K., and Y. Sumita: Acta path. jap. 3, 75 (1953).Google Scholar
  7. 7.
    Lelli, G., e U. Maratta: R. C. Istit. sup. Sanita 13, 503 (1950).Google Scholar
  8. 8.
    Orr, J. W.: J. Path. Bact. 46, 495 (1938).CrossRefGoogle Scholar
  9. 9.
    Randall, J. T., R. D. B. Fraser, A. V. W. Martin, S. F. Jackson and A. C. T. North: Nature (Lond.) 169, 1029 (1952).ADSCrossRefGoogle Scholar
  10. 10.
    Robb-Smith, A. H. T.: The functional significance of connective tissue, in general pathology. Ed. Sir H. Flarey, Chapter 12, p. 255, 1958. London: Lloyd Linke Ltd.Google Scholar
  11. 11.
    Sirsat, M. V.: Ind. J. Surg. 18, 1 (1956).Google Scholar
  12. 12.
    Sirsat, S. M., and V. R. Khanolkar• J Path. Bact. 73, 439 (1957).Google Scholar
  13. 13.
    Stout, A. P.: Cancer 1, 30 (1948).CrossRefGoogle Scholar
  14. 14.
    Tunbridge, R. E., R. N. Tattersall, D. A. Hall, W. T. Astbury and R. Reed: Clin. Sci. 11, 315 (1952).Google Scholar
  15. 15.
    Winer, L. H.: A. M. A. Arch. Derm. 71, 338 (1955).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1960

Authors and Affiliations

  • Satyavati M. Sirsat
    • 1
  1. 1.Department of Electron MicroscopyIndian Cancer Research CentreParel, Bombay 12India

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