During the last decade a growing number of publications have appeared on the biogenesis of collagen. A Russian group of workers (1) were the first to isolate a protein from connective tissue by acid citrate buffer extraction. This protein was considered to be the direct precursor of mature collagen and was named “procollagen”. However more recent and more differentiated work by J. GROSS e. a. (2) and experiments with radio active glycine by Harkness and coworkers (3) have given evidence that the real metabolic precursor was obtained by extraction of the tissue with neutral or weakly alkaline solutions.
Unable to display preview. Download preview PDF.
- 2.Gross, J., J. H. Highberoer and F. O. Schmitt: Proc. nat. Acad. Sci. 41, 1 (1955).Google Scholar
- 3.Harkness, R. D., A. M. Marko, H. M. Muir and A. Neuberger: Biochem. J. 56, 558 (1954).Google Scholar
- 5.Biochem. J. 65, 277 (1957).Google Scholar
- 6.Orekhovitch, K. D.: Dokl. Akad. Nauk. SSSR 71, 521 (1950)Google Scholar
- 7.Hörmann, H.: Beitrag zur Silikoseforschung, Sonderbd. 2, 619 (1958).Google Scholar
- 9.Amer. J. Path. 26, 708 (1950).Google Scholar
- 10.Randall, J. T., G. L. Brown, S. Fitton Jackson, F. C. Kelly, A. C. T. Notre, W. E. Seeds and G. R. Wilkinson: In „Nature and structure of collagen“ p. 213. Butterworth 1953.Google Scholar
- 11.Küxn, K., U. Hofmann, U. W. Grassmann: Z. Naturforsch. 11b, 581 (1956).Google Scholar
- 12.Hooff, A. V. D.: Proc. Kon. Ned. Acad. Wet. C 55, 628 (1952).Google Scholar