Verhandlungen pp 1183-1188 | Cite as

On the procollagens during development of the skin

  • W. Th. Daems
  • D. O. E. Gebhardt
  • G. Smits


During the last decade a growing number of publications have appeared on the biogenesis of collagen. A Russian group of workers (1) were the first to isolate a protein from connective tissue by acid citrate buffer extraction. This protein was considered to be the direct precursor of mature collagen and was named “procollagen”. However more recent and more differentiated work by J. GROSS e. a. (2) and experiments with radio active glycine by Harkness and coworkers (3) have given evidence that the real metabolic precursor was obtained by extraction of the tissue with neutral or weakly alkaline solutions.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Orekhovitch, V. N., and V. O. Srpikiter: Science 127, 1371 (1958).ADSCrossRefGoogle Scholar
  2. 2.
    Gross, J., J. H. Highberoer and F. O. Schmitt: Proc. nat. Acad. Sci. 41, 1 (1955).Google Scholar
  3. 3.
    Harkness, R. D., A. M. Marko, H. M. Muir and A. Neuberger: Biochem. J. 56, 558 (1954).Google Scholar
  4. 4.
    Jackson, D. S., and J. H. Fessler: Nature (Lond.) 176, 69 (1955).ADSCrossRefGoogle Scholar
  5. 5.
    Biochem. J. 65, 277 (1957).Google Scholar
  6. 6.
    Orekhovitch, K. D.: Dokl. Akad. Nauk. SSSR 71, 521 (1950)Google Scholar
  7. 7.
    Hörmann, H.: Beitrag zur Silikoseforschung, Sonderbd. 2, 619 (1958).Google Scholar
  8. 8.
    Gross, J.: J. exp. Med. 107, 265 (1958).CrossRefGoogle Scholar
  9. 9.
    Amer. J. Path. 26, 708 (1950).Google Scholar
  10. 10.
    Randall, J. T., G. L. Brown, S. Fitton Jackson, F. C. Kelly, A. C. T. Notre, W. E. Seeds and G. R. Wilkinson: In „Nature and structure of collagen“ p. 213. Butterworth 1953.Google Scholar
  11. 11.
    Küxn, K., U. Hofmann, U. W. Grassmann: Z. Naturforsch. 11b, 581 (1956).Google Scholar
  12. 12.
    Hooff, A. V. D.: Proc. Kon. Ned. Acad. Wet. C 55, 628 (1952).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1960

Authors and Affiliations

  • W. Th. Daems
    • 1
  • D. O. E. Gebhardt
    • 1
  • G. Smits
    • 1
  1. 1.Laboratory for Electron Microscopy and Histological LaboratoryUniversity of AmsterdamHolland

Personalised recommendations