The problem in the consideration of the comparative aspects of motor units is that of determining whether muscle response is due to one given mechanism involving components of like structure, or to several mechanisms and unlike components in both nerve and muscle. Not long ago this problem was considered essentially physiologic, i. e., that variation in muscle response depended upon differences in mode of innervation of fixed muscle types and also upon the inherent properties of contractile substances.It is now evident that modifications occur in the fundamental intracellular components in relation to specific functional differences, and that differences exist among axons and neuromuscular junctions, as well as among muscle fibers.
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