Verhandlungen pp 1121-1123 | Cite as

The mitochondria in human normal and cholestatic liver

  • R. Ekholm
  • Y. Edlund


Extrahepatic biliary obstruction is accompanied by reduced glycogen content of the liver cells, probably due to impaired glycogenesis as well as enhanced glycogenolysis. The impaired glycogenesis is most likely caused by reduced ATP synthesis, in turn resulting from faulty carbohydrate dissimilation, probably owing to disturbance at some point in the isocitric acid cycle (1). Considering that the enzymes of the Krebs’ cycle seem to be more or less completely located in the mitochondria it seemed justified to ascertain whether biliary obstruction gives rise to morphological changes in liver mitochondria.
Fig. 1

Mitochondria from a normal human liver. The mitochondria are bordered by double edged outer mem branes and contain a few double edged inner membranes. — Magnification 63,000 x

Fig. 2

Mitochondria from a human liver in biliary obstruction. One mitochondrion is very large and contains, in addition to double edged inner membranes, stripy regions (at the arrows). Two of the mitochondria of normal size also have well developed stripy regions. — Magnification 95,000 x


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  1. 1.
    Edlijnd, Y.: Acta chir. stand. 96, suppl. 136 (1948).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1960

Authors and Affiliations

  • R. Ekholm
    • 1
  • Y. Edlund
    • 1
  1. 1.Department of Anatomy and Department of Surgery IIUniversity of GothenburgSweden

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