Abstract: Anchor-Constrained Plausibility

A Novel Concept for Assessing Tractography and Reducing False-Positives
  • Peter F. NeherEmail author
  • Bram Stieltjes
  • Klaus H. Maier-Hein
Conference paper
Part of the Informatik aktuell book series (INFORMAT)


The problem of false positives in fiber tractography is one of the grand challenges in the research area of diffusion-weighted magnetic resonance imaging (dMRI). Facing fundamental ambiguities especially in bottleneck situations, tractography generates huge numbers of theoretically possible candidate tracts. Only a fraction of these candidates is likely to correspond to the true fiber configuration, posing a difficult sensitivity-specificity trade-off.


  1. 1.
    Neher PF, et al. Anchor-constrained plausibility (ACP): a novel concept for assessing tractography and reducing false-positives. Proc MICCAI. 2018;11072:20–27.Google Scholar

Copyright information

© Springer Fachmedien Wiesbaden GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  • Peter F. Neher
    • 1
    Email author
  • Bram Stieltjes
    • 2
  • Klaus H. Maier-Hein
    • 1
    • 3
  1. 1.Division of Medical Image ComputingGerman Cancer Research Center (DKFZ)HeidelbergDeutschland
  2. 2.University Hospital Basel, Radiology & Nuclear Medicine ClinicBaselSchweiz
  3. 3.Section for Automated Image AnalysisHeidelberg University HospitalHeidelbergDeutschland

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