Mouse Hepatitis Virus Infection, Intestine, Mouse

  • Stephen W. Barthold
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Neonatal mice suffer high mortality. They become dehydrated with soiling of the perineum with yellow, diarrheic feces. Their stomachs are usually empty and intestines are thin-walled, flaccid, and contain watery yellow digesta and gas. Juvenile mice are less severely affected, but are often runted with pot bellies and oily-appearing hair. Careful examination of weaning-age or adult mice may reveal dark, sticky feces and opaque, thickened segments of bowel. Livers, if affected, have few to many small pale or hemorrhagic foci (see p. 134, this volume) (Barthold 1985; Barthold and Smith 1984; Barthold et al. 1982; Hierholzer et al. 1979; Ishida and Fujiwara 1979; Ishida et al. 1978; Kraft 1962, 1966).


Lethal intestinal virus of infant mice (LIVIM) 


  1. Barthold SW (1985) Research complications and state of knowledge of rodent coronaviruses. In: Hamm T (ed) Complications of viral and mycoplasmal infections in rodents to toxicology research testing. Hemisphere, Washington DC (in press)Google Scholar
  2. Barthold SW, Smith AL (1984) Mouse hepatitis virus strain-related patterns of tissue tropism in suckling mice. Arch Virol 81: 103–112PubMedCrossRefGoogle Scholar
  3. Barthold SW, Smith AL, Lord PFS, Bhatt PN, Jacoby RO, Main AL (1982) Epizootic coronaviral typhlocolitis in suckling mice. Lab Anim Sci 32: 376–383PubMedGoogle Scholar
  4. Biggers DC, Kraft LM, Sprinz H (1964) Lethal intestinal virus infection of mice (LIVIM). An important new model for study of the response of the intestinal mucosa to injury. Am J Pathol 45: 413–422PubMedGoogle Scholar
  5. Hierholzer JC, Broderson JR, Murphy FA (1979) New strain of mouse hepatitis virus as the cause of lethal enteritis in infant mice. Infect Immun 24: 508–522PubMedGoogle Scholar
  6. Ishida T, Fujiwara K (1979) Pathology of diarrhea due to mouse hepatitis virus in the infant mouse. Jpn J Exp Med 49: 33–41PubMedGoogle Scholar
  7. Ishida T, Fujiwara K (1982) Maternally derived immune resistance to fatal diarrhea in infant mice due to mouse hepatitis virus. Jpn J Exp Med 52: 231–235PubMedGoogle Scholar
  8. Ishida T, Taguchi F, Lee Y-S, Yamada A, Tamura T, Fujiwara K (1978) Isolation of mouse hepatitis virus from infant mice with fatal diarrhea. Lab Anim Sci 28: 269–276PubMedGoogle Scholar
  9. Kraft LM (1962) An apparently new lethal virus disease of infant mice. Science 137: 282–283PubMedCrossRefGoogle Scholar
  10. Kraft LM (1966) Epizootic diarrhea of infant mice and lethal intestinal virus infection of infant mice. Natl Cancer Inst Monogr 20: 55–61PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1985

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  • Stephen W. Barthold

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