Skip to main content
SpringerLink
Log in

Metastasen bei unbekanntem Primärtumor — „CUP-Syndrom“

  • Chapter
Kompendium Internistische Onkologie

Zusammenfassung

Patienten mit Metastasen von unbekannten Primärtumoren sind ein diagnostisches und therapeutisches Problem; ihr Anteil am Patientenkollektiv onkologischer Zentren beträgt 5% bis 10% [30, 41, 19]. „Metastasen bei unbekanntem Primärtumor“ sollten als eigenständiges Syndrom gekennzeichnet werden, da es sich in der Regel um eine besonders maligne biologische Ausdrucksform des — unbekannten -Primärtumors handelt und entsprechende spezifische diagnostische und therapeutische Vorgehensweisen erfordert. Dieses Syndrom wird im folgenden als „CUP-Syndrom“ (Carcinom mit unbekanntem Primärtumor; Carcinoma of Unknown Primary) bezeichnet [30, 28]; ein übliches Synonym ist „Metastasen bei unbekanntem Primärtumor“ (Metastases of Unknown Origin; „MUO“).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Altmannsberger M, Broese M (1984): Immunzytologische Klassifizierung von Metastasen bei unbekanntem Primärtumor. Verh Dtsch Ges Path 68:486

    Google Scholar 

  2. Batsakis JG (1981): The pathology of head and neck tumors. The occult primary and metastases to head and neck, part 10. Head Neck Surg 3:409–423

    Article  PubMed  CAS  Google Scholar 

  3. Didolkar S, Fanous N, Elias EG, et al (1977): Metastatic carcinomas of occult primary tumors. A study of 254 cases. Ann Surg 186:625–630

    CAS  Google Scholar 

  4. Fer MF, Sherwin SA, Oldham RK, Greco FA, Matthews MJ (1982): Poorly differentiated Lung Cancer. Semin Oncol 9:456–466

    PubMed  CAS  Google Scholar 

  5. Fer MF, Levenson RM, Cohen MH et al (1981): Extrapulmonary small cell carcinoma. In: Greco FA, Oldham RK, Bunn PA (eds) Small Cell Lung Cancer, Grune and Stratton New York, pp301–325

    Google Scholar 

  6. Feverman L, Attie JN, Rosenberg B (1962): Carcinoma in axillary lymph nodes. Surg Gynecol Obstet 114: 5 ff

    Google Scholar 

  7. Friedmann W, Steffens J, Lobeck H et al (1984): Immunhistochemische Charakterisierung von Metastasen des Prostatakarzinoms. Verh Dtsch Ges Path 68:115–117

    Google Scholar 

  8. Gatter KC, Mason DY (1982): The Use of Monoclonal Antibodies for Histopathologic Diagnosis of Human Malignancy. Semin Oncol 9:517–525

    PubMed  CAS  Google Scholar 

  9. Gilbert HA, Kagan AR (1976): Metastases: Incidence, detection and evaluation without histologic confirmation. In: Weiss L (ed): Fundamental Aspects of Metastasis. New York, American Elsevier, pp 383–405

    Google Scholar 

  10. Giuliano AE, Alistair JC, Morton DL (1982): Melanoma from unknwon primary site and amelanotic melanoma. Semin Oncol 9:442–447

    PubMed  CAS  Google Scholar 

  11. Goldberg R, Smith F, Meno W et al (1986): Treatment of Adenocarcinoma of unknown primary with Fluorouracil, Adriamycin and Mitomycin C (FAM). Proc Am Soc Clin Oncol 5:129

    Google Scholar 

  12. Goldberg RM, Smith FP et al (1986): 5-Fluorouracil. Adriamycin, and Mitomycin in the Treatment of Adenocarcinoma of unknown Primary. J Clin Oncol 4: 395–399

    PubMed  CAS  Google Scholar 

  13. Greco FA, Oldham RK, Fer FM (1982): The extragonadal Germ Cell Cancer Syndrome. Semin Oncol 9:448–455

    PubMed  CAS  Google Scholar 

  14. Greenberg BR, Salom SE (1984): Human Tumor Clonogenic Assay in Patients with unknown Primary Carcinoma. J Clin Oncol 2:46–50

    PubMed  CAS  Google Scholar 

  15. Hausher FH, Jarbro JW (1985): Diagnosis and Treatment of Malignant Pleural Effusion. Semin Oncol Vol 12:54–75

    Google Scholar 

  16. Johnson RO, Castro R, Ansfield R (1964): Response of primary unknown cancers to treatment with 5-Fluorouracil. Cancer Chemotherapy Rep 38:63–64

    CAS  Google Scholar 

  17. Jordan WE, Shildt RA (1985): Adenocarcinoma of unknown Primary Site. The Brooke Army Medical Center Experience. Cancer 55:857–860

    Google Scholar 

  18. Jundt G, Schulz A, Paul E et al (1984): S-100-Protein in amelanotischen malignen Melanomen. Verh Dtsch Ges Path 68:526

    Google Scholar 

  19. Kambhu S, Kelsen D, et al (1986): Phase II trial of mitomycin C (M), Vindesine (D) and Adriamycin (A) and predictive variables in the treatment of patients (pts) with adenocarcinoma of unknown primary site (ACUP). Proc Am Assoc Cancer Res 27:185

    Google Scholar 

  20. Kehl A (1984): Bedeutung der Punktionszytologie für den Nachweis von Metastasen bei bekanntem oder unbekanntem Primärtumor aus der Sicht des Onkologen. Verh Dtsch Ges Path 68:479–480

    Google Scholar 

  21. Krementz ET, Cerise EJ, Ciaravella JM, et al (1977): Metastases of undetermined source. Cancer 27:289–300

    CAS  Google Scholar 

  22. Lainswoth JD, Greco FA (1986): Clinical characteristics of patients with advanced poorly differentiated carcinoma (PDG) and adenocarcinoma (PDA) of unknown primary who achieved complete response (CR) to combination chemotherapy. Proc Am Soc Clin Oncol 5:127

    Google Scholar 

  23. Le Chavalier Th, Smith FP et al (1985): Sites of primary malignancies in patients presenting with cerebral metastases. Cancer 56:880–882

    Article  Google Scholar 

  24. Le Chevalier T, Caille P et al (1985): Carcinoma of unknown primary. A study of 302 consecutive autopsied patients. Proc Am Soc Clin Oncol 4:8

    Google Scholar 

  25. Mackay B, Ordonez NG (1982): The Role of the Pathologist in the Evaluation of Poorly Differentiated Tumors. Semin Oncol 9:396–418

    PubMed  CAS  Google Scholar 

  26. McGovern NJ (1975): Spontaneous regression of melanoma. Pathology 7:91–99

    Article  PubMed  CAS  Google Scholar 

  27. Metz K, Richter HJ, Leder LD (1984): Immunhistochemische Befunde an großzelligen Lymphomen. Verh Dtsch Ges Path 68:448

    Google Scholar 

  28. Meyer JS (1982): Potential Value of Cell Kinetics in Management of Cancers of unknown origin. Semin Oncol 9:513–516

    PubMed  CAS  Google Scholar 

  29. Mikuz G (1984): Retroperitoneale Lymphknotenmetastasen. Verh Dtsch Ges Path 68:485

    Google Scholar 

  30. Moertel CG, Reitermeier RJ, Schutt AJ, et al (1972): Treatment of the patient with adenocarcinoma of unknown origin. Cancer 30:1469–1472

    Article  PubMed  CAS  Google Scholar 

  31. Müller HA (1984): Lymphknotenmetastasen in der Kopf-Hals-Region. Verh Dtsch Ges Path 68:481

    Google Scholar 

  32. Neumann KH, Nystrom JS (1982): Metastatic Cancer of unknown origin: Nonsquamous Cell Type. Semin Oncol 9:427–434

    PubMed  CAS  Google Scholar 

  33. Nystrom JS, Weiner JM et al (1979): Identifying the primary site in metastatic cancer of unknown origin. JAMA 241:381–383

    Article  PubMed  CAS  Google Scholar 

  34. Osteen RT, Kopf G, Wilson R (1978): In pursuit of the unknown primary. Am J Surg 135:494–497

    Article  PubMed  CAS  Google Scholar 

  35. Pasterz R, et al (1985): Analysis of prognostic factors in patients with metastatic carcinoma of unknown primary. Proc ASCO 4:151

    Google Scholar 

  36. Pfützer P (194): Nachweis von Metastasen in Ergüssen der Körperhöhlen. Verh Dtsch Ges Path 68: 482

    Google Scholar 

  37. Richardson RL, Weiland LH (1982): Undifferentiated small cell carcinomas in extrapulmonary sites. Semin Oncol 9:484–496

    PubMed  CAS  Google Scholar 

  38. Robert NJ, Garnick MB, Frei E (1982): Cancers of unknown origin, Current Approaches and Future Perspectives. Semin Oncol 9:526–531

    PubMed  CAS  Google Scholar 

  39. Ruddon RW (1982): Tumor markers in the Recognition and Management of Poorly Differentiated Neoplasms and Cancers of unknown primary. Semin Oncol 9:416–426

    PubMed  CAS  Google Scholar 

  40. Schaffer R, Müller HA, Osmanns U (1984): Immunzytochemische Befunde in Ausstrichpräparaten aus der Schilddrüse. Verh Dtsch Ges Path 68:497

    Google Scholar 

  41. Schrink-Moormann P, Schwerk U (1984): Lebermetastasen (Zytohisto-logische Untersuchungen). Verh Dtsch Ges Path 68:483

    Google Scholar 

  42. Schwarze EW (1983): Differentialdiagnose der malignen Lymphome unter besonderer Berücksichtigung der Non-Hodgkin-Lymphome. Diagnostik 16:32–34

    Google Scholar 

  43. Shildt RA, Kennedy PS et al (1983): Management of patients with metastatic adenocarcinoma of unknown origin: A Southwest oncology Group study. Cancer Treat Rep. 67:77–79

    PubMed  CAS  Google Scholar 

  44. Silverman C, Marks JE (1982): Metastatic Cancer of unknown origin: Epidermoid and Undifferentiated Carcinoma. Semin Oncol 9:435–441

    PubMed  CAS  Google Scholar 

  45. Sprenger E (1984): Risiko der Metastasierung bei Feinnadelpunktionen. Verh Dtsch Ges Path 68:487

    Google Scholar 

  46. Staub E, Jungi WF, Gloar F, Senn HJ (1981): Lymphknotenmetastasen bei unbekanntem Primärtumor: Sinn und Unsinn einer breiten Abklärung. Schweiz med Wschr 111:1298–1300

    PubMed  CAS  Google Scholar 

  47. Heyden v. HW, Hansen D, Kaboth GA, Hoffmann H, Schneider (1984): Metastasierendes Adenokarzinom bei unbekanntem Primärtumor. Dtsch med Wschr 109:15–19

    Article  Google Scholar 

  48. Walach U (1986): Treatment of adenocarcinoma of unknown origin with cylophosphamide (C), Oncovin (O), Methotrexate (M) and 5-Fluorouracil (F) (COMF). Proc Am Soc Clin Oncol 5:125

    Google Scholar 

  49. Woods RL, Fox RM, et al (1980): Metastatic adenocarcinomas of unknown primary site. N Engl J Med 303:87–89

    Article  PubMed  CAS  Google Scholar 

  50. York JC, Glick AD, Collins RD (1982): Unclassified Leukemias and Lymphomas. Semin Oncol 9:497–503

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. I. Wildfang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H.-J. Schmoll
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wildfang, I., Schmoll, HJ. (1987). Metastasen bei unbekanntem Primärtumor — „CUP-Syndrom“. In: Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96893-8_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96893-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15380-1

  • Online ISBN: 978-3-642-96893-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation