Murine Respiratory Mycoplasmosis, Lung, Rat

  • Trenton R. Schoeb
  • J. Russell Lindsay
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The lungs are externally normal in the majority of infected rats, gross lesions being poorly correlated with clinical signs and microscopic changes. The causative organism, Mycoplasma pulmonis, preferentially affects the nasal passages and middle ears, and the incidence of lesions decreases from the nose distally. The bronchi are the most commonly affected parts of the lungs. Purple, depressed areas of atelectasis may occur in lungs in which exudate obstructs airways. A few rats with advanced disease have gray- or yellow-purple consolidated areas of pneumonia. Yellow, slightly elevated foci representing bronchioles dilated with purulent exudate can affect entire lobes, imparting a cobblestone appearance (Figs. 257 and 258). Frank abscesses also are seen in a few cases. The bronchial and paratracheal lymph nodes may be enlarged to three or four times normal size.


Respiratory Epithelial Cell Cortisone Acetate Purulent Exudate Alveolar Macro Lower Respiratory Tract Disease 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Trenton R. Schoeb
  • J. Russell Lindsay

There are no affiliations available

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