Sendai Virus Infection, Lung, Mouse and Rat

  • David G. Brownstein
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Mice. Asymptomatic or mildly affected mice usually have no gross pulmonary changes other than increased lung weights, although a few mildly affected mice have white lines along the course of bronchi, white foci in lymph nodes, and dual lobes of consolidation. Average increases of 50% have been reported by the 5th day and 100% by the 14th day after experimental infection of Swiss mice (Robinson et al. 1968). Overtly ill and genetically susceptible mice have more dramatic increases in lung weights (200%–300%) (Parker et al. 1978). In these cases, one or more lung lobes are plum-colored or contain sharply demarcated plum-colored foci which exude frothy sanguinous fluid when cut. If these mice survive into the 3rd week, consolidated foci are gray.


Athymic Nude Mouse Alveolar Space Intranuclear Inclusion Sendai Virus Alveolar Septum 
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© Springer-Verlag Berlin Heidelberg 1985

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  • David G. Brownstein

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