Mouse Hepatitis Viral Infection, Adrenal, Mouse

  • Stephen W. Barthold
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Mice that are ill or dying from mouse hepatitis viral (MHV) infection may have gross lesions in a number of organs, depending upon the virus strain. Livers may be diffusely pale, have random depressed white spots and petechiae or be roughly nodular with depression of intervening parenchyma. Hepatitis may be accompanied by small amounts of peritoneal exudate. Mice infected with enterotropic strains may have dilated, fluid-and gas-filled bowels with thin, translucent walls or segments of bowel with thickened walls. The spleen may be enlarged and the thymus reduced. Asymptomatic mice or mice infected with neurotropic strains may have no gross changes (Barthold et al. 1982; Biggers et al. 1964; Hierholzer et al. 1979; Piazza 1969).


Hepatoencephalitis virus murine hepatitis viral infection 


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© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Stephen W. Barthold

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