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Mouse Hepatitis Viral Infection, Adrenal, Mouse

  • Stephen W. Barthold
Chapter
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Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Mice that are ill or dying from mouse hepatitis viral (MHV) infection may have gross lesions in a number of organs, depending upon the virus strain. Livers may be diffusely pale, have random depressed white spots and petechiae or be roughly nodular with depression of intervening parenchyma. Hepatitis may be accompanied by small amounts of peritoneal exudate. Mice infected with enterotropic strains may have dilated, fluid-and gas-filled bowels with thin, translucent walls or segments of bowel with thickened walls. The spleen may be enlarged and the thymus reduced. Asymptomatic mice or mice infected with neurotropic strains may have no gross changes (Barthold et al. 1982; Biggers et al. 1964; Hierholzer et al. 1979; Piazza 1969).

Synonyms

Hepatoencephalitis virus murine hepatitis viral infection 

References

  1. Bang FB (1978) Genetics of resistance of animals to viruses: I. Introduction and studies in mice. Adv Virus Res 23: 269–348PubMedCrossRefGoogle Scholar
  2. Barthold SW, Smith AL, Lord PFS, Bhatt PN, Jacoby RO (1982) Epizootic coronaviral typhlocolitis in suckling mice. Lab Anim Sci 32: 376–383PubMedGoogle Scholar
  3. Biggers DC, Kraft LM, Sprinz H (1964) Lethal intestinal virus infection of mice (LMM). An important new model for study of the response of the intestinal mucosa to injury. Am J Pathol 45: 413–422Google Scholar
  4. Braunsteiner H, Friend C (1954) Viral hepatitis associated with transplantable mouse leukemia. I. Acute hepatic manifestations following treatment with urethane or methylformamide. J Exp Med 100: 665–677Google Scholar
  5. David-Ferreira JF, Manaker RA (1965) An electron microscope study of the development of a mouse hepatitis virus in tissue culture cells. J Cell Biol 24: 57–78PubMedCrossRefGoogle Scholar
  6. Fujiwara K, Tamura T, Hirano N, Takenaka S (1975) Implication pancréatique chez la souris infectée avec le virus de l’hépatite murine. C R Soc Biol (Paris) 169: 477–481Google Scholar
  7. Goto N, Hirano N, Aiuchi M, Hayashi T, Fujiwara K (1977) Nasoencephalopathy of mice infected intranasally with a mouse hepatitis virus, JHM strain. Jpn J Exp Med 47: 59–70Google Scholar
  8. Hierholzer JC, Broderson JR, Murphy FA (1979) New strain of mouse hepatitis virus as the cause of lethal enteritis in infant mice. Infect Immun 24: 508–522PubMedGoogle Scholar
  9. Hirano N, Tamura T, Taguchi F, Ueda K, Fujiwara K (1975) Isolation of low-virulent mouse hepatitis virus from nude mice with wasting syndrome and hepatitis. Jpn J Exp Med 45: 429–432PubMedGoogle Scholar
  10. Le Prevost C, Levy-Leblond E, Virelizier JL, Dupuy JM (1975) Immunopathology of mouse hepatitis virus type 3 infection. I. Role of humoral and cell-mediated immunity in resistance mechanisms. J Immunol 114: 221–225Google Scholar
  11. Piazza M (1969) Hepatitis in mice. In: Experimental viral hepatitis. Thomas, Springfield, Illinois Chapter I IGoogle Scholar
  12. Rowe WP, Hartley JW, Capps WI (1963) Mouse hepatitis virus infection as a highly contagious, prevalent, enteric infection in mice. Proc Soc Exp Biol Med 112: 161–165PubMedGoogle Scholar
  13. Stohlman SA, Sakaguchi AY, Weiner LP (1979) Characterization of the cold-sensitive murine hepatitis virus mutants rescued from latently infected cells by cell fusion. Virology 98: 448–455PubMedCrossRefGoogle Scholar
  14. Taguchi F, Yamada A, Fujiwara F (1979) Asymptomatic infection of mouse hepatitis virus in the rat. Arch Virol 59: 275–279PubMedCrossRefGoogle Scholar
  15. Tardieu M, Héry C, Dupuy JM (1980) Neonatal susceptibility to MHV3 infection in mice. II. Role of natural effector marrow cells in transfer of resistance. J Immunol 124: 418–423Google Scholar
  16. van der Riet F de SU, Kahn LB (1973) Isolation of murine hepatitis virus from Swiss mice treated with antilymphocyte serum. Arch Viro! 42: 1–8CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

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  • Stephen W. Barthold

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