Aspects of Pharmacokinetics of Opiates
When a drug has been absorbed into the blood stream a series of processes take place which are mostly interrelated: dispositions in tissues and organs, excretion, metabolism. Most interesting is the permeation towards the target organ, in the case of narcotic analgesics, towards the brain. This paper will mainly deal with the kinetics of this permeation and other problems shall be treated only in so far as they are helpful to understand this particular process.
Unable to display preview. Download preview PDF.
- Goldstein, A., Aronow, L., Kalman, S. K.: Principles of Drug Action. New York: Harper & Row Publ. 1968.Google Scholar
- Herz, A., Teschemacher, HJ.: Activities and sites of anti-nociceptive action of morphine-like analgesics and kinetics of distribution following intravenous, intracerebral and intraventricular application. Advanc. Drug. Res. 6, 79–119 (1971).Google Scholar
- Höllt, V., Teschemacher, HJ.: Hydrophobic interaction effective in binding of morphine-like analgesics to albumine, plasma-proteins and tissue homogenates. Naunyn-Schmiedeberg’s Arch. Pharmacol. Suppl. 274, R. 53 (1972).Google Scholar
- Hug, C. C., Oka, T.: Uptake of 3H-dihydromorphine by synaptosomes. Life Sci. Part I 10, 201 (1971).Google Scholar
- Misra, A. L.: Disposition and metabolism of drugs of dependence. In: Mule, S. J., Brill., H. (Eds.): Chemical and biological aspects of drug dependence, pp. 219–270. Cleveland: CRP-Press 1972.Google Scholar
- Scholtan, W.: Die hydrophobe Bindung der Pharmaka an Humanalbumin und Ribonucleinsäure. Arzneimittel-Forsch. 18, 305–317 (1968).Google Scholar
- Schubert, P., Teschemacher, HJ., Kreutzberg, G. W., Herz, A.: Intracerebral distribution pattern of radioactive morphine and morphine-like drugs after intraventricular and intrathecal injection. Histochemie 22, 277–288 (1970).Google Scholar
- Takemori, A. E., Stenwick, M. W.: Studies on the uptake of morphine by the choroid plexus in vitro. J. Pharmacol. exp. Ther. 454, 586–594 (1966).Google Scholar
- Teschemacher, HJ., Hess, R., Niedner, I., Herz, A.: Characteristics of morphine permeation into the central nervous system after intravenous injection in rabbits. V. Intern. Congress of Pharmacology, San Francisco, p. 232 (1972).Google Scholar