Mediator Gene Expression in Sepsis: Implications for Therapy

  • K. L. Brigham
  • A. E. Canonico
  • J. T. Conary
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 16)


Diffuse lung injury resulting in the clinical entity commonly called the adult respiratory distress sydrome (ARDS), remains highly lethal. Since the clinical description of the syndrome about 20 years ago, mortality in published series of patients has changed very little. This is true in spite of major advances in the technology of critical care medicine. Although a large amount of research has dramatically enhanced the understanding of mechanisms of lung injury and respiratory failure in ARDS, this has, so far, not translated into demonstrably effective pharmacological interventions.


Lung Injury Acute Lung Injury Cystic Fibrosis Transmembrane Regulator Chloramphenicol Acetyl Transferase Pulmonary Artery Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • K. L. Brigham
  • A. E. Canonico
  • J. T. Conary

There are no affiliations available

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