The O-2A Progenitor during Development and Remyelination

  • Monique Dubois-Dalcq
  • Regina Armstrong
  • Bryn Watkins
  • Randall McKinnon
Conference paper
Part of the NATO ASI Series book series (volume 43)


We are investigating the factors controlling growth and differentiation of oligodendrocytes precursor cells during CNS myelination and remyelination. These studies have stemmed from the description of O-2A progenitor cells in the newborn rat optic nerve (reviewed in Raff, 1989). These progenitor cells are bipotential since they can differentiate either into oligodendrocytes, which form myelin in the CNS, or type 2 astrocytes, which extend processes to nodes of Ranvier. Therefore, the lineage derived from this progenitor is called the oligodendrocyte-type 2 astrocyte (O-2A) lineage. O-2A progenitor cells are identified by immunolabeling with an antibody to cell surface gangliosides (A2B5) or glycoproteins (NSP4). O-2A progenitor cells purified and cultured from newborn rat brain (Behar et al., 1988) are shown in Figure 1.


Glial Fibrillary Acidic Protein Oligodendrocyte Development Glial Progenitor Cell Demyelinating Episode Cell Surface Ganglioside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Monique Dubois-Dalcq
    • 1
  • Regina Armstrong
    • 1
  • Bryn Watkins
    • 1
  • Randall McKinnon
    • 1
  1. 1.Laboratory of Viral and Molecular PathogenesisNational Institute of Neurological Disorders and StrokeBethesdaUSA

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