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The O-2A Progenitor during Development and Remyelination

  • Monique Dubois-Dalcq
  • Regina Armstrong
  • Bryn Watkins
  • Randall McKinnon
Conference paper
  • 55 Downloads
Part of the NATO ASI Series book series (volume 43)

Abstract

We are investigating the factors controlling growth and differentiation of oligodendrocytes precursor cells during CNS myelination and remyelination. These studies have stemmed from the description of O-2A progenitor cells in the newborn rat optic nerve (reviewed in Raff, 1989). These progenitor cells are bipotential since they can differentiate either into oligodendrocytes, which form myelin in the CNS, or type 2 astrocytes, which extend processes to nodes of Ranvier. Therefore, the lineage derived from this progenitor is called the oligodendrocyte-type 2 astrocyte (O-2A) lineage. O-2A progenitor cells are identified by immunolabeling with an antibody to cell surface gangliosides (A2B5) or glycoproteins (NSP4). O-2A progenitor cells purified and cultured from newborn rat brain (Behar et al., 1988) are shown in Figure 1.

Keywords

Glial Fibrillary Acidic Protein Oligodendrocyte Development Glial Progenitor Cell Demyelinating Episode Cell Surface Ganglioside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Armstrong R, Friedrich VL Jr, Holmes KV, Dubois-Dalcq M (1988) In vitro analysis of neuroglial cells isolated during demyelination and remyelination. Soc Neurosci Abstr 14: 787Google Scholar
  2. Armstrong R, Friedrich VL Jr, Holmes KV, Dubois-Dalcq M (1989) Proliferation and differentiation of neuroglial cells isolated during demyelination and remyelination. Ann NY Acad Sci (in press )Google Scholar
  3. Aranella LS, Herndon RM (1984) Mature oligodendrocytes division following expeirmental demyelination in adult animals. Arch Neurology 41: 1162–1165CrossRefGoogle Scholar
  4. Barde Y-A (1989) Trophic factors and neuronal survival. Neuron 2: 1525–1534PubMedCrossRefGoogle Scholar
  5. Behar T, McMorris FA, Novotny EA, Barker JL, Dubios-Dalcq M (1988) Growth and differentiation properties of 0–2A progenitors purified from rat cerebral hemispheres. J Neurosci Res 21: 168–180PubMedCrossRefGoogle Scholar
  6. Besnard F, Perraud F, Sensenbrenner M, Labourdette G (1989) Effects of acidic and basic fibroblast growth factors on proliferation and maturation of cultured rat oligodendrocytes. Int J Develop Neurosci in pressGoogle Scholar
  7. Claesson-Welsh L, Eriksson A, Westermark B, Heldin C-H (1989) cDNA cloning and expression of the human A-type platelet-derived growth factor ( PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proc Natl Acad Sci USA 86: 4917–4921PubMedCrossRefGoogle Scholar
  8. Dubois-Dalcq M (1987) Characterization of a slowly proliferative cell along the oligodendrocyte differentiation pathway EMBO 6: 2587–2595Google Scholar
  9. Eccleston PA, Silberberg DH (1985) Fibroblast growth factor is a mitogen for oligodendrocytes in vitro. Dev Brain Res 21: 315–318CrossRefGoogle Scholar
  10. Ferrara N, Ousley F, Gospodarowicz D (1988) Bovine brain astrocytes express basic fibroblast growth factor, a neurotropic and angiogenic mitogen. Brain Research 462: 223–232PubMedCrossRefGoogle Scholar
  11. Finkelstein SP, Apostolides PJ, Caday CG, Prosser J, Philips MF, Klagsbrun M (1988) Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of local brain wounds. Brain Res 460: 253–259CrossRefGoogle Scholar
  12. Ffrench-Constant C, Raff MC (1986) Proliferating bipotentiai glial progenitor cells in adult rat optic nerve. Nature 319: 499–502PubMedCrossRefGoogle Scholar
  13. Gard AL, Pfeiffer SE (1989) Oligodendrocyte progenitors isolated directly from developing telencephalon at a specific phenotypic stage myelinogenic potential in a defined environment. Development 106: 119–132PubMedGoogle Scholar
  14. Godfraind C, Friedrich VL, Holmes KV, Dubois-Dalcq M (1989) In vivo analysis of glial cell phenotypes during a viral demyelinating disease in mice. J Cell Biology (in press)Google Scholar
  15. Hart CE, Forstrom JW, Kelly JD, Seifert RA, Smith RA, Ross R, Murray MJ, Bowen-Pope DF (1988) Two classes of PDGF receptor recognize different isoforms of PDGF. Science 240: 1529–1534PubMedCrossRefGoogle Scholar
  16. Hart IK, Richardson WD, Heldin C-H, Westermark B, Raff MC (1989) PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage. Development 105: 595–603PubMedGoogle Scholar
  17. Hatten ME, Lynch M, Rydel RE, Sanchez J, Joseph-Silverstein J, Moscatelli D, Rifkin DB (1988) In vitro neurite extension by granule neurons is dependent upon astroglialderived fibroblast growth factor. Develop Biol 125: 280–289PubMedCrossRefGoogle Scholar
  18. Heldin C-H, Backstrom G, Ostman A, Hammacher A, Ronnstrand L, Rubin K, Nister M, Westermark B (1988) Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J 7: 1387–1393PubMedGoogle Scholar
  19. Herndon RM, Price DL, Weiner LP (1977) Regeneration of oligodendroglia during recovery from demyelinating disease. Science 195: 693–694PubMedCrossRefGoogle Scholar
  20. Hunter SE, Seidel MF, Bottenstein JE (1988) Response of neonatal and adult glial progenitors to neuronal cell line-derived mitogens. Soc Neurosci Abstr 14: 321Google Scholar
  21. Jordan C, Friedrich VL, deFerra F, Weismiller D, Holmes K, Dubois-Dalcq M (1989a) Differential exon expression in myelin basic protein transcripts during CNS remyelination. J Cellular and Molecular Neurobiol (in press )Google Scholar
  22. Jordan C, Friedrich VL, Godfraind C, Holmes KV, Dubois-Dalcq M (1989b) Expression of viral and myelin gene transcripts in a murine demyelinating disease caused by a corona virus. Glia (in the press)Google Scholar
  23. Lillien LE, Sendtner M, Rohrer H, Hughes SM, Raff MC (1988) Type-2 astrocyte development in rat brain cultures is initiated by a CNTF-like protein produced by type-1 astrocytes. Neuron 1: 485–494PubMedCrossRefGoogle Scholar
  24. Levine JM (1989) Neuronal influences on glial progenitor cell development. Neuron 3: 103–113PubMedCrossRefGoogle Scholar
  25. Ludwin SK, (1981) Pathology of demyelination and remyelination. In: Waxman SG, Ritchie JM (eds) Advances in neurology Vol 31. Demyelinating diseases. Raven Press, New York, 123–168Google Scholar
  26. Ludwin SK, Sternberger NH (1984) An immunohistochemical study of myelin proteins during remyelination in the central nervous system. Acta Neuropathologica 63: 240–248PubMedCrossRefGoogle Scholar
  27. Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Krous M, Peirce J, Aaronson S (1989) Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science 243: 800–804PubMedCrossRefGoogle Scholar
  28. McKinnon RD, Matsui TA, Aaronson S, Dubois-Dalcq, M (1989) FGF inhibits myelin gene expression and induces the PDGF-a receptor in differentiating 0–2A glial progenitor cells. American Society for Cell Biology, 29th Annual MeetingGoogle Scholar
  29. McMorris FA, Dubois-Dalcq M (1988) Insulin-like growth factor 1 promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro. J Neurosci Res 21: 199–209PubMedCrossRefGoogle Scholar
  30. Nieto-Sampedro M, Manthorpe M, Barbin G, Varon S, Cotman CW (1983) Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity. J Neuroscience 3: 2219–2229Google Scholar
  31. Pettmann B, Labourdette G, Weibel M, Sensenbrenner M (1986) The brain fibroblast growth factor is localized in neurons. Neuroscience Letters 68: 175–180PubMedCrossRefGoogle Scholar
  32. Pringle N, Collarini EJ, Mosley MJ, Heldin C-H, B Westermark B, Richardson WD (1989) PDGF A chain homodimers drive proliferation of bipotential (O-2A) glial progenitor cells in the developing rat optic nerve. EMBO J 8: 1049–1056PubMedGoogle Scholar
  33. Raff MC (1989) Glial cell diversification in the rat optic nerve. Science 243: 1450–1455PubMedCrossRefGoogle Scholar
  34. Raff MC, Abney ER, Fok-Seang J (1985) Reconstitution of a developmental clock in vitro: A critical role for astrocytes in the timing of oligodendrocytes. Cell 42: 61–69PubMedCrossRefGoogle Scholar
  35. Raff MC, Lillien LE, Richardson WD, Burne JF, Noble MD (1988) Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature 333: 562–565PubMedCrossRefGoogle Scholar
  36. Raff MC, Miller RH, Noble M (1983) A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature 303: 390–396PubMedCrossRefGoogle Scholar
  37. Raff MC, Williams BP, Miller RH (1984) The in vitro differentiation of a bipotential glial progenitor cell. EMBO 3: 1857–1864Google Scholar
  38. Richardson WD, Pringle N, Mosley JD, Westermark B, Dubois-Dalcq M (1988) A role for platelet-derived growth factor in normal gliogenesis in the central nervous system. Cell 53: 303–319CrossRefGoogle Scholar
  39. Ross R, Raines EW, Bowen-Pope DF (1986) The biology of platelet-derived growth factor. Cell 46: 155–169PubMedCrossRefGoogle Scholar
  40. Saneto RP, deVellis J (1985) Characterization of cultured rat oligodendrocytes proliferating in a serum-free, chemically defined medium. Proc Natl Acad Sci USA 82: 3509–3513PubMedCrossRefGoogle Scholar
  41. Skoff R, Price D, Stocks A (1976) Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve I cell proliferation. J Comp Neurol 169: 291–312PubMedCrossRefGoogle Scholar
  42. Sommer I, Noble M (1986) Plasticity and commitment in oligodendrocyte development. Soc Neurosci Abstr 12: 1585Google Scholar
  43. Temple S, Raff MC (1986) Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions. Cell 44: 773–779PubMedCrossRefGoogle Scholar
  44. Van-Obberghen-Schilling E, Behar T, Sporn MB, Dubois-Dalcq M (1987) Signalling between type 1 astrocytes and their glial 0–2A progenitors: Modulation by transforning growth factor-beta (TGFB). J Cell Biol 105 (4): 318Google Scholar
  45. Wolswijk G, Noble M (1989) Identification of an adult-specific glial progenitor cell. Development 105: 387–400PubMedGoogle Scholar
  46. Yarden Y, Escobedo JA, Kuang W-J, Yang-Feng TL, Daniel TO, Tremble PM, Chen EY, Ando ME, Harkins RN, Francke U, Fried VA, Ullrich A, Williams LT (1986) Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323: 226–232PubMedCrossRefGoogle Scholar
  47. Zeller NK, Behar TN, Dubois-Dalcq M, Lazzarini RA (1985) The timely expression of myelin basic protein gene in cultured rat brain oligodendrocytes is independent of continuous neuronal influences. J Neurosci 5: 2955–2962PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Monique Dubois-Dalcq
    • 1
  • Regina Armstrong
    • 1
  • Bryn Watkins
    • 1
  • Randall McKinnon
    • 1
  1. 1.Laboratory of Viral and Molecular PathogenesisNational Institute of Neurological Disorders and StrokeBethesdaUSA

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