Measlesvirus-Induced Cellular Autoimmune Reactions
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Subacute encephalomyelitis (SAME) in Lewis rats following infection with a neurotropic measles virus (MV) is associated with a cellmediated autoimmune response (CMAI) to myelin basic protein (MBP) and proteolipid apoprotein (PLP). Grown in vitro the autoreactive T cell lines are CD4+, class II MHC-restricted, and the MBP-specific T cell lines are encephalitogenic when adoptively transferred into naive recipients. MBP-selected CD4+ T cell lines both from measles infected animals as well as from rats with experimental allergic encephalomyelitis (EAE), as a consequence of challenge with MBP, shared the same antigenicspecificity. Our data indicate that MV infection of the central nervous system (CNS) enhances the susceptibility of the CNS to autoimmune T cell aggression.
KeywordsMyelin Basic Protein Measle Virus Experimental Allergic Encephalomyelitis Stimulation Index Acute Measle
- Hallpike JF, Adams CWM, Tourtellotte WW (1983) Multiple Sclerosis. Chapman and Hill, London, p.379.Google Scholar
- Johnson RT (1982) Viral infections of the Nervous System. Raven Press, New York.Google Scholar
- Zamvil SS, Nelson PA, Mitchell OJ, Knobler RL, Fritz RB, Steinman L (1985) J. expo Med. 162:1027.Google Scholar