Nervous System pp 180-186 | Cite as

Mouse Hepatitis Virus Infection, Brain, Mouse

  • Stephen W. Barthold
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Infection of most adult mice is usually subclinical, with no gross lesions. In susceptible mice, gross lesions can occur in multiple organs, including multiple focal areas of necrosis or hemorrhage in liver, intestinal ulceration or mucosal thickening, lymphoadenomegaly and splenomegaly. Gross brain lesions are not visible, but encephalitic signs can include tremor, incoordination, and convulsions (Piazza 1969). Some mice can manifest posterior paresis (Bailey et al. 1949; Sebesteny and Hill 1974), and athymic nude mice develop cachexia (wasting disease) due to chronic infections (Sebesteny and Hill 1974).


Mouse hepatitis virus (MHV) hepatoencephalitis virus murine hepatitis virus mouse coronavirus infection 


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© Springer-Verlag Berlin Heidelberg 1988

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  • Stephen W. Barthold

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