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Coagulopathies

  • Fritz Reinhard Matthias
Chapter
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Abstract

The pathogenetic principle of plasmatic clotting disorders is the reduced or missing activity of one or more plasmatic factors during the coagulation process in vivo. Reduced activity may be caused
  1. 1.

    by a quantitative reduction in the factor or factors concerned, either through reduced synthesis or as a result of increased turnover,

     
  2. 2.

    by a qualitative defect in the protein structure of the clotting factor, which prevents normal activity or function,

     
  3. 3.

    by the presence of an inhibitor in the plasma which blocks the development of the activity.

     

Keywords

Factor Viii Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Thrombin Time Factor Viii Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Fritz Reinhard Matthias
    • 1
  1. 1.Department of Internal MedicineJustus Liebig-UniversityGießenFederal Republic of Germany

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