Sepsis pp 180-201 | Cite as

Sepsis and Leukocyte Function: Harm and Benefit

  • J. J. Zimmerman


Although invading microbes and their associated toxins may initiate sepsis, it is the host’s violent inflammatory response that largely defines the sepsis syndrome [1, 2]. Aberrations in immune function and metabolism may result in multiple organ system failure. Septic shock thus reflects profound cellular dysfunction as a consequence of a variety of dysmetabolic events. Leukocytes representing the infantry of the host defense system appear to play a leading role in various causal phenomena associated with sepsis. A variety of defects in cell-mediated immunity may place the individual in jeopardy for sepsis. However, these same cellular elements orchestrate the inflammation-amplification response characteristic of the host autoinjury septic syndrome. This brief review examines the dual role — harm and benefit — of leukocytes in sepsis.


Acquire Immune Deficiency Syndrome Polymorphonuclear Leukocyte Adult Respiratory Distress Syndrome Common Variable Immune Deficiency Leukocyte Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. J. Zimmerman

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