Immunmodulation nach parenteraler Glutaminzufuhr in der Dickdarmchirurgie
Immune Modulation Following Parenteral Glutamine Provision in Colonic Surgery
The influence of parenteral L-alanyl-L-glutamine dipeptide on the cysteinyl-leukotriene (cys-LT) synthesizing capacity from neutrophils was studied in patients undergoing colonic surgery. The decrease in cys-LT, observed postoperatively, could be normalized with parenteral glutamine, while the cys-LT decrease persisted in controls. We conclude that the provision of glutamine in the postoperative state improves normalization of neutrophil functions (e.g., generation of cys-LT), which is an essential prerequisite for host defences.
Key wordsGlutamine total parenteral nutrition immunology
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