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Immunmodulation nach parenteraler Glutaminzufuhr in der Dickdarmchirurgie

  • B. J. Morlion
  • H.-P. Siedhoff
  • U. Joosten
  • M. Köller
  • W. König
  • R. Fürst
  • C. Puchstein
Conference paper
Part of the Langenbecks Archiv für Chirurgie book series (DTGESCHIR, volume 1996)

Immune Modulation Following Parenteral Glutamine Provision in Colonic Surgery

Summary

The influence of parenteral L-alanyl-L-glutamine dipeptide on the cysteinyl-leukotriene (cys-LT) synthesizing capacity from neutrophils was studied in patients undergoing colonic surgery. The decrease in cys-LT, observed postoperatively, could be normalized with parenteral glutamine, while the cys-LT decrease persisted in controls. We conclude that the provision of glutamine in the postoperative state improves normalization of neutrophil functions (e.g., generation of cys-LT), which is an essential prerequisite for host defences.

Key words

Glutamine total parenteral nutrition immunology 

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Literatur

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • B. J. Morlion
    • 1
  • H.-P. Siedhoff
    • 1
  • U. Joosten
    • 2
  • M. Köller
    • 3
  • W. König
    • 3
  • R. Fürst
    • 4
  • C. Puchstein
    • 1
  1. 1.Klinik für Anästhesiologie und operative IntensivmedizinRuhr-Universität BochumHerneDeutschland
  2. 2.Chirurgische Klinik, Marienhospital HerneRuhr-Universität BochumHerneDeutschland
  3. 3.Abteilung für InfektabwehrRuhr-Universität BochumHerneDeutschland
  4. 4.Institut für Biologische Chemie und ErnährungswissenschaftUniversität HohenheimStuttgartDeutschland

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