Multiples Organversagen nach schwerem Trauma: vorhersagbar durch den Leberfunktionstest MEGX?
Multiple Organ Failure Following Severe Trauma: Predictability Using the Liver-function Test MEGX
The prognostic value of a dynamic liver-function test, based on the hepatic conversion of lidocaine to monoethylglycinexylidide (MEGX), in predicting multiple organ failure (MOF) was prospectively investigated in 28 critically ill patients after multiple trauma. The MEGX test and conventional static liver tests (bilirubin, aspartate aminotransferase, glutamate dehydrogenase and factor V) were performed on days 1, 3, 5, and 7 after trauma and patients were classified by a modified MOF score into a group without (n=18) and a group with the MOF syndrome (n=9). All patients who subsequently developed MOF, however, displayed a sharp decrease in their MEGX values between days 1 and 3.
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