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Sekretionshemmung in der Pankreaschirurgie reduziert die postoperative Komplikationsrate: Eine Metaanalyse von vier Multizenterstudien

  • H. Friess
  • W. Uhl
  • M. Schilling
  • M. W. Büchler
Conference paper
Part of the Langenbecks Archiv für Chirurgie book series (DTGESCHIR, volume 1996)

Zusammenfassung

In vier randomisierten, plazebo-kontrollierten, doppelblinden Multizenterstudien wurde die Wertigkeit einer perioperativen Pankreas-Sekretionshemmung mit Octreotid in der elektiven Pankreaschirurgie untersucht. Die Anzahl von postoperativen Komplikationen (329 Plazebo, 206 Octreotid) als auch die Anzahl von Patienten mit postoperativen Komplikationen (Plazebo 38%, Octreotid 22%) waren in den Plazebo-gruppen signifikant höher als in den Octreotidgruppen. Die Krankenhausmortalität war in beiden Gruppen nicht unterschiedlich (Plazebo 3.9%, Octreotid 3.5%). Diese Ergebnisse zeigen, daß eine perioperative Sekretionshemmung mit Octreotid, postoperative Komplikationen in der elektiven Pankreaschirurgie reduziert.

Schlüsselwörter

Pankreasoperationen postoperative Komplikationen Octreotid 

Inhibition of Secretion in Pancreatic Surgery Reduces the Postoperative Complication Rate: A Meta-analysis of Four Multicenter Studies

Summary

We report on a meta-analysis of four randomized, placebo-controlled, double-blind multicenter trials evaluating the role of perioperative octreotide treatment in the prevention of postoperative complications following elective pancreatic surgery. From a total of 963 patients (483 placebo, 480 octreotide), the postoperative complication rate (329 placebo, 206 octreotide) and the number of patients with postoperative complications (placebo 38%, octreotide 22%) were significantly higher in the placebo groups compared with the octreotide groups. Postoperative mortality was comparable between the placebo (3.9%) and the octreotide (3.5%) groups. These data indicate that perioperative application of octreotide can prevent postoperative complications following pancreatic surgery.

Key words

Pancreatic surgery prevention postoperative complications octreotide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. Friess
    • 1
  • W. Uhl
    • 1
  • M. Schilling
    • 1
  • M. W. Büchler
    • 1
  1. 1.Klinik für Viszerale und TransplantationschirurgieUniversität Bern, InselspitalBernSchweiz

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