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Adjuvante intraoperative Strahlentherapie (IORT) beim Magenkarzinom

  • H.-J. Krämling
  • R. Wilkowski
  • E. Dühmke
  • C. Cramer
  • N. Willich
  • F. W. Schildberg
Conference paper
Part of the Langenbecks Archiv für Chirurgie book series (DTGESCHIR, volume 1996)

Adjuvant Intraoperative Radiation Therapy (IORT) for Gastric Cancer

Summary

In order to evaluate the role of adjuvant IORT in the treatment of resectable gastric carcinoma, we carried out a randomized trial comparing surgery and surgery + adjuvant IORT. The study included 115 patients within a 74-month period, 51 of them received a single application of 28 Gy to the celiac axis. Patients were comparable with regard to age, sex, tumor stage and operative morbidity. The difference in mean survival time (IORT: 26.9 months vs. non-IORT: 30.8 months) and tumor-related death in the long-term course (mean follow-up period 29.2 months) with 29.4% (15/51) in the IORT-treated patients vs. 31.2% (20/64) in non-irradiated patients did not reach significance.

Key words

Intraoperative radiation therapy IORT Stomach neoplasms Gastric cancer Adjuvant therapy Randomized controlled clinical trial 

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Literatur

  1. 1.
    Abe M, Shibamoto Y, Takahashi M, Manabe T, Tobe T, Inamoto T (1987) Intraoperative radiotherapy in carcinoma of the stomach and pancreas. World J Surg 11: 459–464PubMedCrossRefGoogle Scholar
  2. 2.
    Japanese Research Society for Gastric Cancer (1981) The general rules for the gastric cancer study in surgery and pathology. Jpn J Surg 11: 127–139CrossRefGoogle Scholar
  3. 3.
    Krämling HJ, Willich N, Denecke H, Grab J, Schildberg FW (1991) Prospective randomized study on IORT for resectable gastric carcinoma. In: Abe M, Takahashi M (Hrsg) Intraoperative Radiation Therapy. Pergamon, New York, pp 192–194Google Scholar
  4. 4.
    Ogata T, Araki K, Matsuura K, Kobayashi M, Inomata T, Yasuhiro O, Yoshida S (1995) A 10-year experience of intraoperative radiotherapy for gastric carcinoma and a new surgical method of creating a wider irradiation field for cases of total gastrectomy patients. Int J Radiat Oncol Biol Phys 32: 341–347PubMedCrossRefGoogle Scholar
  5. 5.
    Sindelar WE, Kinsella TJ, Tepper JE, DeLaney TF, Maher MM, Smith R, Rosenberg SA, Glatstein E (1993) Randomized trial of intraoperative radiotherapy in carcinoma of the stomach. Am J Surg 165: 178–187PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H.-J. Krämling
    • 1
  • R. Wilkowski
    • 2
  • E. Dühmke
    • 2
  • C. Cramer
    • 1
  • N. Willich
    • 3
  • F. W. Schildberg
    • 1
  1. 1.Chirurgische Klinik und Poliklinik, Klinikum GroßhadernLudwig-Maximilians-UniversitätMünchenDeutschland
  2. 2.Klinik für Strahlentherapie und Radioonkologie, Klinikum GroßhadernLudwig-Maximilians-UniversitätMünchenDeutschland
  3. 3.Klinik und Poliklinik für Strahlentherapie/RadioonkologieWestfälische Wilhelms-UniversitätMünsterDeutschland

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