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Molekularbiologische Merkmale des Neuroblastoms als Grundlage eines Therapiekonzepts

  • R. Girgert
  • J. Treuner
  • P. Schweizer
Conference paper
Part of the Langenbecks Archiv für Chirurgie book series (DTGESCHIR, volume 1996)

Zusammenfassung

Zur Optimierung der Therapie des dessiminierten Neuroblastoms sollten die molekularbiologischen Merkmale der Tumore, die die Prognose beeinflussen, berücksichtigt werden. Zu diesen Faktoren zählen: N-myc-Amplifikation, 1p36-Deletion, Ploidie und trk-Expression. Neuroblastome ohne N-myc-Amplifikation und hoher trk-Ex-pression haben eine günstige Prognose und können mit einer schonenderen Chemotherapie behandelt werden. Neuroblastome mit N-myc-Amplifikation und fehlender trk-Expression verhalten sich extrem ungünstig und bedürfen einer noch intensiveren Behandlung.

Schlüsselwörter

Neuroblastom Molekularbiologie Therapiekonzept Prognose 

Molecular Biological Markers of Neuroblastoma as the Basis for a Concept of Treatment

Summary

Molecular biological markers that influence prognosis should be considered in the optimization of therapy for disseminated forms of neuroblastoma. Some of these markers include: N-myc amplification, deletion of lp36, ploidy, and trk expression. Neuroblastoma without N-myc amplification and high trk expression show a favorable outcome and would enable a more gentle chemotherapy treatment. Neuroblastomas with N-myc amplification and lack of trk expression behave extremely unfavorably and require an even more intensive treatment.

Key words

Neuroblastoma Biology Treatment Prognosis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • R. Girgert
    • 1
  • J. Treuner
    • 2
  • P. Schweizer
    • 1
  1. 1.Klinikum Schnarrenberg, Abteilung KinderchirurgieUniversität TübingenTübingenDeutschland
  2. 2.Abteilung Hämatologie und OnkologieOlgahospital StuttgartStuttgartDeutschland

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