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Die isolierte hypertherme Extremitätenperfusion beim Malignen Melanom mit Melphalan und Tumornekrosefaktor

  • C. Kettelhack
  • P. Hohenberger
  • P. M. Schlag
Conference paper
Part of the Langenbecks Archiv für Chirurgie book series (DTGESCHIR, volume 1996)

Isolated Hyperthermic Limb Perfusion for Malignant Melanoma with Melphaland and Tumor Necrosis Factor

Summary

Isolated limb perfusion (ILP) with tumor necrosis factor (TNF) and melphalan was carried out in 21 patients with regionally metastatic malignant melanoma of the limbs. The observed response rate was 65% complete and 15% partial remission. These results warrant further investigation of ILP with TNF and melphalan vs ILP with melphalan alone in a prospective randomised multicenter trial.

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Literatur

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    Kettelhack C, Kraus T, Hupp T, Manner M., Schlag P (1990) Hyperthermic limb perfusion for malignant melanoma and soft tissue sarcoma. Eur J Surg Oncol 16:370–375PubMedGoogle Scholar
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    Lienard D, Eggermont AMM, Schraffordt Koops H, Kroon BBR, Rosenkaimer F, Autier P, Lejeune FJ (1994) Isolated perfusion of the limb with high-dose tumor necrosis factor-alpha (TNF-α), inter-feron-gamma (IFN-γ) and melphalan for melanoma stage III. Results of a multi-center pilot study. Melanoma Res 4 (S 1): 21–26PubMedGoogle Scholar
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    Lienard D, Ewalenko P, Delmotte JJ, Lejeune FJ (1992) High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J Clin Oncol 10:52–60PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • C. Kettelhack
    • 1
  • P. Hohenberger
    • 1
  • P. M. Schlag
    • 1
  1. 1.Virchow-Klinikum, Robert-Rössle-KlinikHumboldt-UniversitätBerlinDeutschland

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