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Ist die Lebertransplantation als chirurgisches Therapiekonzept bei Metastasen neuroendokriner Tumoren gerechtfertigt?

  • H. Lang
  • K. J. Oldhafer
  • H. J. Schlitt
  • G. F. W. Scheumann
  • B. Ringe
  • R. Pichlmayr
Conference paper
Part of the Langenbecks Archiv für Chirurgie book series (DTGESCHIR, volume 1996)

Liver Grafting for Neuroendocrine Hepatic Metastases: A Justified Therapy?

Summary

Between 1982 and February 1996 11 patients underwent liver transplantation for irresectable neuroendocrine hepatic metastases. The operative mortality was one of 11, while two patients died due to sepsis respectively tumor recurrence 7 and 68 months after transplantation. Eight patients are alive with a median survival of 55 months (range from 10 days to 8.5 years). In three patients there is no evidence of tumor and the longest disease-free survival is 102 months after LTx.

These results suggest that liver transplantation represents a justified treatment for irresectable hepatic metastases arising from neuroendocrine tumors.

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Literatur

  1. 1.
    O’Grady JG, Poison RT, Rolles K, Calne RY, Williams R (1988) Liver transplantation for malignant disease: results in 93 consecutive patients. Ann Surg 267:373–379CrossRefGoogle Scholar
  2. 2.
    Pichlmayr R, Weimann A, Ringe B (1994) Indications for liver transplantation in hepatobiliary malignancy. Hepatology 20:33–40Google Scholar
  3. 3.
    Makowka L, Tzakis AG, Mazzaferro V, Teperman L, Demetris A, Iwatsuki S, Starzl TE (1989) Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas. Surg Gynecol Obstet 168:107–111PubMedCentralPubMedGoogle Scholar
  4. 4.
    Arnold JC, O’Grady JG, Bird GL, Calne RY, Williams R (1989) Liver transplantation for primary and secondary hepatic apudoma. Br J Surg 76:248–249PubMedCrossRefGoogle Scholar
  5. 5.
    Ahlman H, Westberg G, Wängberg B, Nilsson O, Tylen U, Schersten T, Tisell LE (1996) Treatment of liver metastases of carcinoid tumors. World J Surg 20:196–202PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. Lang
    • 1
  • K. J. Oldhafer
    • 1
  • H. J. Schlitt
    • 1
  • G. F. W. Scheumann
    • 1
  • B. Ringe
    • 2
  • R. Pichlmayr
    • 1
  1. 1.Klinik für Abdominal- und TransplantationschirurgieMedizinische Hochschule HannoverHannoverDeutschland
  2. 2.Klinik für TransplantationschirurgieGeorg-August-UniversitätGöttingenDeutschland

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