Inhaled Nitric Oxide in Acute Respiratory Failure

  • L. Puybasset
  • J. J. Rouby
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1995)


Gazeous nitric oxide (NO) and nitrogen dioxide (NO2) are well known atmospheric outdoor pollutants which toxicity was extensively studied in the seventies. In the eighties, inhaled NO was used in humans as an alternative to CO to measure the oxygen diffusing capacity of the lungs [1, 2]. In 1987, one of the endothelium-derived relaxing factors [3] was identified as NO [4]. It was then demonstrated that NO was continuously released by the endothelial cells after activation of the constitutive NO synthase in response to shear stress. Later, NO was found to be involved in a large number of physiological systems [5, 6] such as coagulation [7, 8], neuronal transmission and inflammation.


Nitric Oxide Pulmonary Hypertension Pulmonary Arterial Hypertension Acute Respiratory Failure Adult Respiratory Distress Syndrome 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • L. Puybasset
  • J. J. Rouby

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