Noninstrumental Detection of Influenza Viruses by Enzyme Immunoassay

  • R. Pottathil
  • M. W. Harmon
  • L. Keys
  • K. Desai


Influenza viruses are usually associated with epidemic respiratory infections in all age groups (Glenzen 1982; Kendal and Walls 1987). Influenza A and B produce symptoms in humans that are not pathognomonic. During epidemics, the infection may be diagnosed on a clinical basis. However, isolated cases, as well as patients seen at the beginning of an outbreak between epidemics, are difficult to diagnose clinically. A series of infectious agents such as respiratory syncytial virus, adenovirus, corona virus, rhinovirus, the parainfluenza virus group, and Mycoplasma pneumonia can produce the clinical symptoms often designated as “the flu” (Huley 1987). Definitive diagnosis of influenza virus infection has traditionally relied on viral isolation or serology. However, the time required for laboratory diagnosis has often exceeded the duration of the disease. These delayed laboratory reports coupled with the lack of specific therapy resulted in decreased interest in obtaining a laboratory diagnosis. However, the recent availability of specific antiviral agents and rapid diagnostic techniques have revived the interest in laboratory diagnosis.


Influenza Virus Respiratory Syncytial Virus Latex Particle Laboratory Diagnosis Weak Reaction 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • R. Pottathil
    • 1
  • M. W. Harmon
    • 2
  • L. Keys
  • K. Desai
    • 2
  1. 1.Roche Diagnostic Systems, Inc.NutleyUSA
  2. 2.Center for Disease ControlAtlantaUSA

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